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Phosphoramidites (often abbreviated as amidites) are building blocks used in chemical synthesis of oligonucleotides. Automated oligo synthesizers complete sequential chemical reactions using phosphoramidites to produce the nucleotide chains of synthetic oligos.

Thermo Scientific DNA phosphoramidites are built to meet the varying needs of oligonucleotide manufacturers for the development of therapeutic, diagnostic, and research applications. We offer TheraPure, standard, and fast deprotect phosphoramidites.

Structural, nonstandard phosphoramidites are used to synthesize modified oligonucleotides. Oligos with these specialty phosphoramidites are often used as primers, probes, or in structural studies. Structural phosphoramidites can be custom manufactured with base or sugar (2′, 3′ or 5′ positions)...

Thermo Scientific RNA phosphoramidites are built to meet the varying needs of oligonucleotide manufacturers for the development of therapeutic, diagnostic, and research applications. We offer TheraPure, standard, and fast deprotect phosphoramidites.

Read about: Oligo synthesis Oligo usage in diagnostics Oligo usage in therapeutics Phosphoramidites in oligo manufacturing Phosphoramidite considerations for diagnostic applications Phosphoramidite considerations for therapeutic applications, Oligonucleotides (oligos) are short pieces of DNA and RNA...

Dye-labeled phosphoramidites are intended for oligonucleotide synthesis designed for molecular assays, microscopy, and microarrays. A broad range of labeling options are available with coupling efficiency, emission, and absorption spectra comparable to other commercially available dyes.

Seamlessly scale up your synthesis of siRNA and ASO for RNA therapeutics from early-stage development to commercial manufacturing with a comprehensive portfolio of Thermo Scientific TheraPure 2’ modified RNA phosphoramidites and TheraPure customization capabilities .

Browse through our curated selection of learning resources to enable your success in oligonucleotide synthesis for diagnostic and therapeutic development. View available technical assets related to using phosphoramidites in the development of oligonucleotide diagnostics and therapeutics.

Oligonucleotide therapeutics are an up-and-coming class of drugs comprised of short DNA and/or RNA molecules that modulate the expression of target RNA for the treatment of diseases. Common types of oligonucleotide therapeutics include antisense oligonucleotides (ASOs), small interfering RNAs...

Linker phosphoramidites provide options to link oligonucleotides to additional groups (e.g., chemical delivery system for therapeutics, fluorescent dyes, amines, phosphates) or attach to a solid surface like a DNA chip.

Oligonucleotide therapeutics have attracted much attention recently. They represent an up-and-coming class of therapeutic options that can lead to major advances in the treatment or cure of diseases, holding great potential for further development in human medicine.

Nucleic acid therapeutics are changing healthcare by delivering promising drugs that use new technologies and modes of action to treat disease. Several of these innovative medicines are being utilized to treat infectious diseases, protein and gene deficiencies, and many types of cancers.

Succinates are used for the derivatization of controlled pore glass, polystyrene, or other supports for solid-phase oligonucleotide synthesis. Our DNA succinates are formulated as triethylammonium (TEA) salts with standard base protection.

We offer a range of pre-designed oligos for a variety of applications. Random Hexamer and Oligo dT Primers are suitable for first-strand cDNA synthesis with a reverse transcriptase. Sequencing Primersare complementary to common cloning vectors elements and allow for sequencing of cloned DNA...

Our standard custom DNA oligonucleotides are synthesized on a highly automated, computer-controlled system using cyanoethyl phosphoramidite chemistry and subject to rigorous quality control procedures, just like our Value Oligos.