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Our specialized products, innovative technologies and customized workflow solutions help expand and compliment the portfolios of life science tool providers., PCR & RT-PCR enzymes DNA/RNA modifying enzymes Restriction enzymes Molecular cloning enzymes Lyo-ready enzymes Enzyme engineering and...

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Quantitative calibration standard for HPLC analysis of protein hydrolysates; a mixture of 18 amino acids, each at 2.5 micromoles/mL in 0.1 N HCl. A carboxylic acid-reactive compound (A max 260 nm; UV) to label, detect and measure peptides and amino acids by HPLC; also called p-Bromophenacyl-8.

Comprehensive characterization of biotherapeutics is necessary to satisfy safety standards set by regulatory agencies and helps to ensure protein drug efficacy. Intact protein analysis using a combination of liquid chromatography (LC) and mass spectrometry (MS) provides information on the accurate...

Next generation Invitrogen protein immunoassays utilize promixity-based amplification technology, recent advances combine the sensitivity and dynamic range of qPCR amplification with the specificity of antibodies for protein detection.

Proteins control all biological systems in a cell, and while many proteins perform their functions independently, the vast majority of proteins interact with others to execute a full range of biological activities.

The discovery and development of effective cancer immunotherapy requires a better understanding of the tumor and its surrounding environment. Different stages of cancer progression depend on the tumor, the organ in which it resides, and the immune response.

(See a list of the products featured in this article.) Parkinson’s disease (PD) is a debilitating, chronic, and progressive neurological disease that affects around 10 million people worldwide.Parkinson’s disease is accompanied by loss of motor function and, without a curative treatment, care...

Overview of crosslinking reagents In vivo and in vitro crosslinking General reaction conditions Protein–protein interaction analysis Recommended reading, Protein Crosslinking Protein Purification Accessories Cell Lysis (Total Protein Extraction) Western Blotting Immunoprecipitation Protein...

We offer kits and crosslinker systems for specialized crosslinking strategies, including photoreactive amino acids (leucine & methionine) for metabolic labeling and biotin label transfer compounds for protein-protein interaction experiments.

Label transfer methodology Traditional label transfer reagents Nonradioactive label transfer reagents Recommended reading, Sulfo-SBED Biotin Label Transfer Reagent Iodination Reagents for Proteins Biotin Binding Protein Conjugates, In a typical label transfer reaction, a bait protein reacts with a...

See all protein interaction analysis products, Introduction to protein–protein interactions Types of protein–protein interactions Biological effects of protein–protein interactions Common methods to analyze protein–protein interactions Co-immunoprecipitation (co-IP) Pull-down assays Crosslinking...

Precast gels, running buffers, molecular weight markers, and gel stain for sample preparation, loading, and analysis when studying proteins by electrophoresis (SDS-PAGE), Kits, reagents, and devices, including iBlot 2 dry blotting system, SuperSignal chemiluminescent substrates, and iBind system for...

Because the proteome is so complex, there is no one standard method for preparing protein samples for analysis by mass spectrometry (MS). Protocols differ depending on sample type, experimental goals, and analytical method used.

Protein aggregation is a biological phenomenon in which proteins accumulate and clump together. Protein aggregation is one of the key challenges in the development of protein biotherapeutics. It is a critical product quality issue as well as a potential safety concern due to the increased...