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RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.

RAF1/c-RAF Polyclonal Antibody (Bethyl Laboratories)

RAF1/c-RAF Polyclonal Antibody for Western Blot, IP

RAF1 Monoclonal Antibody (1D6A1) (Proteintech)

RAF1 Monoclonal Antibody for Western Blot, IHC (P)

RAF1/c-RAF Polyclonal Antibody (Bethyl Laboratories)

RAF1/c-RAF Polyclonal Antibody for Western Blot

RAF1 Polyclonal Antibody (Proteintech)

RAF1 Polyclonal Antibody for IHC (P)

RAF1 Polyclonal Antibody (Proteintech)

RAF1 Polyclonal Antibody for Western Blot, IHC (P)

RAF1 Polyclonal Antibody (Proteintech)

RAF1 Polyclonal Antibody for Western Blot, IHC (P)

Phospho-c-Raf (Tyr340, Tyr341) Polyclonal Antibody (Invitrogen™)

Phospho-c-Raf (Tyr340, Tyr341) Polyclonal Antibody for Western Blot, IHC

BRAF Recombinant Human Protein

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron.

Phospho-c-Raf (Ser259) Polyclonal Antibody (Invitrogen™)

Phospho-c-Raf (Ser259) Polyclonal Antibody for Western Blot, IF, ICC

Fluorescein-MAP2K1

Inactive MAP2K1 (MEK1) has been labeled with fluorescein, and is a substrate for MAPK family members.

For use in combination with the LanthaSreen™ Tb-MAP2K1 [pSer217/221] Antibody (PV4813) to evaluate inhibitors in medium to high throughput screening applications.

BRAF [V599E] Recombinant Human Protein

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers.

Phospho-c-Raf (Ser621) Polyclonal Antibody (Invitrogen™)

Phospho-c-Raf (Ser621) Polyclonal Antibody for Western Blot

LanthaScreen™ Tb-pMAP2K1 (pSer217/221) Antibody Kit

A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217/221 by a range of MAPK family members including Raf and B-Raf. For use in combination with the Fluorescein-MAP2K1 physiological protein substrate (PV4812) to evaluate inhibitors in medium to high throughput screening applications.

Phospho-c-Raf (Ser338, Tyr340) Polyclonal Antibody (Invitrogen™)

Phospho-c-Raf (Ser338, Tyr340) Polyclonal Antibody for Western Blot