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Specifications Sheet: GRAMS Suite – A Solution for Visualizing, Processing, and Managing Spectroscopy Data Product Literature

Newsletter: Getting to the Truth of the Grain Product Literature

How does the TruScan RM Handheld Raman Analyzer work? Product FAQ

Answer

In Raman spectroscopy, an unknown sample of material is illuminated with monochromatic (single wavelength or single frequency) laser light, which can be absorbed, transmitted, reflected, or scattered by the sample. Light scattered from the sample is due to either elastic collisions of the light with the sample molecules (Rayleigh scatter) or inelastic collisions (Raman scatter). Whereas Rayleigh scattered light has the same frequency (wavelength) of the incident laser light, Raman scattered light returns from the sample at different frequencies corresponding to the vibrational frequencies of the bonds of the molecules in the sample.

If you wish to learn more about Raman spectroscopy, visit our online Raman Spectroscopy Academy (https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/spectroscopy-elemental-isotope-analysis-learning-center/molecular-spectroscopy-information/raman-technology.html), where you will find basic Raman tutorials, advanced Raman webinars on sample applications, and a helpful instrument guide.

The TruScan RM Handheld Raman Analyzer is built with a state-of-the-art optical platform paired with a field-proven embedded chemometrics engine. The patented, multivariate residual analysis offers the most effective chemometric solution for material identification, with two spectral pre-processing options (1st and 2nd derivative), that is easy to operate in challenging environments and sampling conditions.

In addition to Raman technology, the TruScan RM Handheld Raman Analyzer has TruTools, an optional embedded chemometrics software package (https://assets.thermofisher.com/TFS-Assets/CAD/Specification-Sheets/TSRM-TruTools-SpecSheet-2016-FINAL.pdf), with which users can build advanced, customized qualitative and quantitative methods for complex material analysis problems. TruTools models allow discrimination of multiple components, discrimination of raw materials with minimal spectral differences (such as ethanol and methylated spirits), and discrimination of low API dosage tablets from placebos. With TruTools deployed on a TruScan RM Handheld Raman Analyzer, non-expert operators can run advanced chemometric analyses anywhere in the plant.

Answer Id: E20649

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How does the Acclaro Contaminant Identification feature work on my NanoDrop One Spectrophotometer? Product FAQ

Answer

Our Acclaro Contaminant Identification feature uses a chemometric approach to analyze the chemical components present in a sample. This type of analysis has been used previously in Fourier transform infrared spectroscopy (FTIR) and near-infrared systems (e.g. Thermo Scientific Nicolet spectrometers). The Acclaro algorithms rely on a reference library of spectra. These algorithms are then applied to the sample spectrum, and the software can make predictions about a sample's contaminants by using chemometric mathematical principles.

Answer Id: E17779

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How can Infrared (IR) be used quantitatively in spectroscopy? Do I have to build a calibration curve? Product FAQ

Answer

Quantitative work requires one of two approaches. First, you may know or can calculate the absorptivitiy (the epsilon in Beer's Law). This is exceedingly rare. Much more commonly, you can develop a set of training / calibration standards and record spectra. You can then either use a chemometrics package like Thermo Scientific TQ Analyst software to automate the analysis using Beer's Law or more complex modeling, or you can record basic information (peak height or peak area) in a spreadsheet and then use linear (or non-linear) regression. It is generally the same idea as done for chromatography or atomic spectroscopy.

Answer Id: E20634

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What are the advantages of FTNIR spectroscopy versus dispersive NIR spectroscopy? Product FAQ

Answer

Fourier Transform NIR (FTNIR) systems have advantages in higher resolution, better wavelength accuracy, higher signal energy, and are more stable and repeatable. FTNIR systems do not require software standardization for method transfer between instruments. Also FTNIR systems are not affected by stray light which causes sampling challenges for dispersive NIR systems.

Answer Id: E20693

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I need support regarding my FT-IR / Mattson FT-IR / Nicolet FT-IR / Industrial/Raman / Software and Libraries / Fluorescence / UV-Vis products. Where can I find help? Product FAQ

Answer

Please to go https://kb.unitylabservices.com/?cid=12825&c=13142&cpc=iCia805H4XUv1Ub1aS0kPQGY1OLg7MkTjK for support on our molecular spectroscopy products.

Answer Id: E16428

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Applications Notebook: Oil & Gas Application Notebook – Complete Workflow Solutions: Chromatography, Mass Spectrometry, Molecular Spectroscopy, Lab Data Management Software Product Literature

Fluorescein, Oregon Green and Rhodamine Green Dyes—Section 1.5 Molecular Probes Handbook

Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition. Citations & References

  • Authors: Tsurui H, Nishimura H, Hattori S, Hirose S, Okumura K, Shirai T
  • Journal: J Histochem Cytochem
  • PubMed ID: 10769049
Catalog #

Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopy. Citations & References

  • Authors: Gilbert GE, Baleja JD
  • Journal: Biochemistry
  • PubMed ID: 7893714
Catalog # F150

Alexa Fluor Dyes Spanning the Visible and Infrared Spectrum—Section 1.3 Molecular Probes Handbook

Lipid bilayer vesicle fusion: intermediates captured by high-speed microfluorescence spectroscopy. Citations & References

  • Authors: Lei G, MacDonald RC
  • Journal: Biophys J
  • PubMed ID: 12944275
Catalog #

Characterization of Food and Pharmaceutical Packaging by Molecular Spectroscopy Scientific Poster

Protein Detection on Gels, Blots and Arrays—Section 9.3 Molecular Probes Handbook

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