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Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO), gamma-irradiated:

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting
Gamma-irradiated—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes

10K Dialysis Membrane Specifications
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be loaded with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

The 10K molecular-weight cutoff (MWCO) cassettes use a low-binding regenerated cellulose that is rated to completely retain proteins and other macromolecules that are larger than 10,000 daltons while allowing removal of buffer salts and small contaminants. Membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free. The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL.

Gamma-irradiated (Sterile) Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer G2 Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ G2 Dialysis Cassettes, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 15 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 70 mL

Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 12 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassettes (10K MWCO) facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules that are larger than 10,000 daltons.
The 12 mL size is convenient for preparative applications and gamma irradiation assures sterility.

Features of Slide-A-Lyzer Dialysis Cassettes:

Easy to use—no knots or clamps are needed; just inject sample into cassette and begin dialysis
Fast dialysis—flat cassette chamber with two membranes provides high surface-area to volume ratio that maximizes diffusion rate compared to cylindrical dialysis tubing
High recovery—rectangular cassette design maximizes recovery of entire sample volume via any one of the four corner injection ports
Four cassette sizes—select the cassette that best suits your sample volume
Color-coded—orange cassette frame specifies cassettes with the 10,000 MW pore size membrane
Gamma-irradiated option—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination

10K Dialysis Membrane Specifications:
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

Slide-A-Lyzer Dialysis cassettes are available in four different sizes to accommodate sample volumes between 0.1 and 30 mL. These devices are easier to use than traditional dialysis tubing, providing both faster buffer exchange and more complete sample recovery. Slide-A-Lyzer Cassettes can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and sample concentration. Liquid samples are easily added and removed by penetrating the self-sealing gasket with a hypodermic needle attached to a syringe. No knots, clips or caps are needed to seal the units and prevent leaking and sample-loss during the dialysis procedure.

Gamma-irradiated Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

Slide-A-Lyzer Dialysis Cassettes are constructed from two sheets of low-binding, regenerated-cellulose dialysis membrane that are hermetically sealed on either side of a silicone-like gasket inside an inert plastic frame. The membrane and cassette materials are compatible with most common laboratory chemicals and buffers.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ Dialysis Cassettes, 10K MWCO, 12 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL

Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO), gamma-irradiated:

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting
Gamma-irradiated—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes

10K Dialysis Membrane Specifications
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be loaded with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

The 10K molecular-weight cutoff (MWCO) cassettes use a low-binding regenerated cellulose that is rated to completely retain proteins and other macromolecules that are larger than 10,000 daltons while allowing removal of buffer salts and small contaminants. Membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free. The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL.

Gamma-irradiated (Sterile) Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer G2 Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ G2 Dialysis Cassettes, 10K MWCO, 3 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 15 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 70 mL

Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassettes (10K MWCO) facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules that are larger than 10,000 daltons.
The 0.5 mL size is convenient for low volume samples and gamma irradiation assures sterility.

Features of Slide-A-Lyzer Dialysis Cassettes:

Easy to use—no knots or clamps are needed; just inject sample into cassette and begin dialysis
Fast dialysis—flat cassette chamber with two membranes provides high surface-area to volume ratio that maximizes diffusion rate compared to cylindrical dialysis tubing
High recovery—rectangular cassette design maximizes recovery of entire sample volume via any one of the four corner injection ports
Four cassette sizes—select the cassette that best suits your sample volume
Color-coded—orange cassette frame specifies cassettes with the 10,000 MW pore size membrane
Gamma-irradiated option—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination

10K Dialysis Membrane Specifications:
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

Slide-A-Lyzer Dialysis cassettes are available in four different sizes to accommodate sample volumes between 0.1 and 30 mL. These devices are easier to use than traditional dialysis tubing, providing both faster buffer exchange and more complete sample recovery. Slide-A-Lyzer Cassettes can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and sample concentration. Liquid samples are easily added and removed by penetrating the self-sealing gasket with a hypodermic needle attached to a syringe. No knots, clips or caps are needed to seal the units and prevent leaking and sample-loss during the dialysis procedure.

Gamma-irradiated Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

Slide-A-Lyzer Dialysis Cassettes are constructed from two sheets of low-binding, regenerated-cellulose dialysis membrane that are hermetically sealed on either side of a silicone-like gasket inside an inert plastic frame. The membrane and cassette materials are compatible with most common laboratory chemicals and buffers.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ Dialysis Cassettes, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 12 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL

Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 15 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO), gamma-irradiated:

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting
Gamma-irradiated—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes

10K Dialysis Membrane Specifications
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be loaded with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

The 10K molecular-weight cutoff (MWCO) cassettes use a low-binding regenerated cellulose that is rated to completely retain proteins and other macromolecules that are larger than 10,000 daltons while allowing removal of buffer salts and small contaminants. Membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free. The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL.

Gamma-irradiated (Sterile) Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer G2 Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ G2 Dialysis Cassettes, 10K MWCO, 15 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 70 mL

Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassettes (10K MWCO) facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules that are larger than 10,000 daltons.
The 3 mL size is convenient for many applications and gamma irradiation assures sterility.

Features of Slide-A-Lyzer Dialysis Cassettes:

Easy to use—no knots or clamps are needed; just inject sample into cassette and begin dialysis
Fast dialysis—flat cassette chamber with two membranes provides high surface-area to volume ratio that maximizes diffusion rate compared to cylindrical dialysis tubing
High recovery—rectangular cassette design maximizes recovery of entire sample volume via any one of the four corner injection ports
Four cassette sizes—select the cassette that best suits your sample volume
Color-coded—orange cassette frame specifies cassettes with the 10,000 MW pore size membrane
Gamma-irradiated option—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination

10K Dialysis Membrane Specifications:
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

Slide-A-Lyzer Dialysis cassettes are available in four different sizes to accommodate sample volumes between 0.1 and 30 mL. These devices are easier to use than traditional dialysis tubing, providing both faster buffer exchange and more complete sample recovery. Slide-A-Lyzer Cassettes can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and sample concentration. Liquid samples are easily added and removed by penetrating the self-sealing gasket with a hypodermic needle attached to a syringe. No knots, clips or caps are needed to seal the units and prevent leaking and sample-loss during the dialysis procedure.

Gamma-irradiated Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

Slide-A-Lyzer Dialysis Cassettes are constructed from two sheets of low-binding, regenerated-cellulose dialysis membrane that are hermetically sealed on either side of a silicone-like gasket inside an inert plastic frame. The membrane and cassette materials are compatible with most common laboratory chemicals and buffers.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ Dialysis Cassettes, 10K MWCO, 3 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 12 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL

Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO), gamma-irradiated:

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting
Gamma-irradiated—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes

10K Dialysis Membrane Specifications
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be loaded with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

The 10K molecular-weight cutoff (MWCO) cassettes use a low-binding regenerated cellulose that is rated to completely retain proteins and other macromolecules that are larger than 10,000 daltons while allowing removal of buffer salts and small contaminants. Membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free. The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL.

Gamma-irradiated (Sterile) Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer G2 Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ G2 Dialysis Cassettes, 10K MWCO, 30 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 15 mL
Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 70 mL

Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 30 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassettes (10K MWCO) facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules that are larger than 10,000 daltons.
The 30 mL size is convenient for larger-scale applications and gamma irradiation assures sterility

Features of Slide-A-Lyzer Dialysis Cassettes:

Easy to use—no knots or clamps are needed; just inject sample into cassette and begin dialysis
Fast dialysis—flat cassette chamber with two membranes provides high surface-area to volume ratio that maximizes diffusion rate compared to cylindrical dialysis tubing
High recovery—rectangular cassette design maximizes recovery of entire sample volume via any one of the four corner injection ports
Four cassette sizes—select the cassette that best suits your sample volume
Color-coded—orange cassette frame specifies cassettes with the 10,000 MW pore size membrane
Gamma-irradiated option—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination

10K Dialysis Membrane Specifications:
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

Slide-A-Lyzer Dialysis cassettes are available in four different sizes to accommodate sample volumes between 0.1 and 30 mL. These devices are easier to use than traditional dialysis tubing, providing both faster buffer exchange and more complete sample recovery. Slide-A-Lyzer Cassettes can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and sample concentration. Liquid samples are easily added and removed by penetrating the self-sealing gasket with a hypodermic needle attached to a syringe. No knots, clips or caps are needed to seal the units and prevent leaking and sample-loss during the dialysis procedure.

Gamma-irradiated Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

Slide-A-Lyzer Dialysis Cassettes are constructed from two sheets of low-binding, regenerated-cellulose dialysis membrane that are hermetically sealed on either side of a silicone-like gasket inside an inert plastic frame. The membrane and cassette materials are compatible with most common laboratory chemicals and buffers.

More Product Data
Separation characteristics of dialysis membranes

Related Products
Slide-A-Lyzer™ Dialysis Cassettes, 10K MWCO, 30 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 12 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 0.5 mL
Slide-A-Lyzer™ Dialysis Cassettes, gamma-irradiated, 10K MWCO, 3 mL

Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO (Thermo Scientific™)

The Thermo Scientific Pierce RED Device for Rapid Equilibrium Dialysis provides the easiest, fastest and most reliable system for performing plasma protein-binding assays, a critical step in drug development. This product includes a single-use plate with 8K MWCO inserts.

Features of the RED Device for Rapid Equilibrium Dialysis:

Easy and ready to use—disposable tubes require no presoaking, assembly or specialized equipment
Designed for speed—the high surface-to-volume ratio of the insert design enables equilibrium to be reached in as few as 100 minutes with vigorous agitation or in three to four hours with 200rpm agitation
Automation-compatible—designed on a standard 96-well plate template suitable for automated liquid handlers
Flexible and scalable—perform any number of assays (1 to 48 assays per plate) without wasting the entire plate
Robust—compartmentalized design eliminates potential for cross talk or leakage
Reproducible and accurate—validated for plasma binding assays, producing results consistent with those reported in literature
Quality-tested—each lot of inserts is functionally tested in a protein-binding assay for guaranteed performance

The Pierce Device for rapid equilibrium dialysis (RED) was developed in association with the pharmaceutical industry to provide the easiest, fastest and most reliable system for performing plasma protein-binding assays.

The RED Device is an apparatus for performing equilibrium dialysis experiments in a high throughput, automation-compatible format, and consists of disposable inserts and a base plate formatted to a standard microplate footprint. It has been extensively validated for plasma-binding assays and produces results consistent with those reported in the literature. The RED Device also offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available equilibrium dialysis systems.

Features of the RED Device Inserts:
Each single-use, disposable insert is made of two side-by-side chambers separated by a vertical cylinder of dialysis membrane (in 8K or 12K MWCO) validated for minimal nonspecific binding. This format requires no extensive assembly steps or specialized equipment, and each chamber or well is easily accessible from the top of the insert after insertion in the base plate. Additionally, the high surface-to-volume ratio of the membrane compartment allows rapid dialysis, where equilibrium can be reached in 4 hours with high levels of reproducibility and accuracy. In many cases, experiments can be completed in less than 100 minutes.

Insert Features:
• Disposable: require no presoaking, assembly, or specialized equipment
• Short incubation time: large dialysis surface area accelerates equilibrium
• 8K MWCO membrane: ideal molecular-weight cutoff for protein-drug binding studies
• 12K MWCO membrane also available for larger drug molecules
• Membrane composition: regenerated cellulose with low glycerol content as a humectant

Features of the RED Device Base Plates:
RED Device Inserts are designed to be used with either the reusable PTFE or disposable high-density polypropylene base plates. Each RED Device Base Plate holds up to 48 RED Device Inserts and has a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems. In addition, the disposable RED Device Base Plates are available pre-loaded, providing operation convenience for scientists conducting protein-binding applications. No pre-conditioning of the membrane inserts is needed. When using radioactive materials, this single-use plate is easily disposed of to avoid contamination and cleaning. RED Device Inserts and Base Plates are also available separately.

Base Plate Features:
• Microplate footprint: compatible with automated systems for 96-well plates
• Compartmentalized: eliminates potential for crosstalk or leakage
• PTFE construction: eliminates nonspecific binding and risk of contamination
• Accepts 1 to 48 inserts: run exactly the number of assays needed without waste

Applications:
• Determination of free vs. drug bound to plasma proteins
• Pharmacokinetics studies
• Formulation of drug dosage for in vivo studies
• Drug-drug interaction studies
• Selection criteria during drug lead optimization
• Drug partition between plasma and whole blood
• Solubility study
• Dissociation constant determination (Kd)
• Tissue-binding study using tissue homogenate

Determining the extent to which a molecule binds to plasma proteins is a critical phase of pharmaceutical development because it influences compound dosing, drug efficacy, clearance rate and potential for drug interactions. This determination is enabled by equilibrium dialysis, an accepted standard method for reliable estimation of the nonbound drug fraction in plasma. Although it is the preferred method, equilibrium dialysis is generally labor-intensive, time-consuming, cost-prohibitive and difficult to automate. The RED Device for rapid equilibrium dialysis was developed in close association with the pharmaceutical industry to specifically address these issues, accelerating lead optimization and reducing the attrition rate. In addition to plasma protein binding, the device is used for determining drug partition between red blood cell and plasma, protein binding of liver microsomes to improve the correlation between in vitro and in vivo intrinsic clearance, the competition between tissue protein binding against plasma proteins and dissociation constant determination (Kd).

The RED Device has been extensively validated for plasma-binding assays producing results consistent with those reported in the literature. For example, when used to measure warfarin binding to plasma (human and rat) proteins at two concentrations of 1 µM and 10 µM, the RED Device produced results with minimal intra-experimental variability. The Rapid Equilibrium Dialysis (RED) Device offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available systems.

Related Products
Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Reusable Base Plate
Rapid Equilibrium Dialysis (RED) Device Single-Use Base Plates
Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool
Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 12K MWCO

Slide-A-Lyzer™ G2 Dialysis Cassettes, gamma-irradiated, 10K MWCO, 70 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (10K MWCO), gamma-irradiated:

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting
Gamma-irradiated—gamma-irradiated cassettes are available for applications requiring conditions that minimize the risk of sample contamination
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes

10K Dialysis Membrane Specifications
Composition: Regenerated cellulose synthesized by the Viscose method
Thickness: 0.9 to 1.2mil (22.5 to 30 µM)
Hydration Required Before Use: 30 seconds for small-volume samples
Glycerol Content: 21%
Sulfur Content: 0.05%
Heavy Metals Content: Trace

The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be loaded with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

The 10K molecular-weight cutoff (MWCO) cassettes use a low-binding regenerated cellulose that is rated to completely retain proteins and other macromolecules that are larger than 10,000 daltons while allowing removal of buffer salts and small contaminants. Membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free. The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL.

Gamma-irradiated (Sterile) Dialysis Cassettes:
Gamma-irradiated Slide-A-Lyzer G2 Dialysis Cassettes are ideal for researchers culturing cells and microorganisms; purifying viruses, DNA and RNA; or performing sample preparation for other applications requiring conditions that minimize the risk of sample contamination. The gamma-irradiated cassettes are treated with 20-36 kGy of gamma radiation, a dosage that has been determined to sterilize the units based on both trypticase soy broth medium for identifying total growth and fluid thioglycollate medium for identifying anaerobic growth. However, a confirmation of sterility is not provided for individual lots, as no further sterility testing is conducted post irradiation.

More Product Data
Separation characteristics of dialysis membranes

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SnakeSkin™ Dialysis Clips (Thermo Scientific™)

Thermo Scientific SnakeSkin Dialysis Tubing Clips are sturdy, non-floating tube closures recommended for use with SnakeSkin Dialysis Tubing and other suitable dialysis tubing with flat tube diameters up to 50mm.

Features of SnakeSkin Dialysis Tubing Clips:

Durable—polyamide composition for long-life
Dove-tail latch—prevent sample loss
Heat resistant—autoclave up to 134°C

Dialysis Clip Specifications:
Height: 10mm
Width: 16mm
Inner Length: 50mm (maximum closure width)
Outer Length: 66mm (end to end)
Composition: Polyamide (nylon) derivative

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Slide-A-Lyzer™ Cassette Syringes, 5 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassette Syringes are designed for efficiently loading samples into Slide-A-Lyzer cassettes and removing the sample after dialysis. The 5 mL syringes are a convenient size for use with 3 mL cassettes (66380, 66381)

Features of Slide-A-Lyzer Dialysis Syringes:

• Matched to the Slide-A-Lyzer to minimize losses
• Chemically inert - will not contaminate product
• Appropriately sized for different sample volumes

These accessories are for use with Slide-A-Lyzer Dialysis Cassettes to remove low molecular weight contaminants and perform buffer exchange, desalting and concentration.

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Slide-A-Lyzer™ G2 Dialysis Cassettes, 2K MWCO, 30 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (2K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (2K MWCO):

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting

The 2K molecular-weight cut off (MWCO) cassettes use a cellulose membrane that is rated to completely retain proteins and other macromolecules that are larger than 2000 daltons while allowing removal of buffer salts and small contaminants. The cassette membrane is composed of low-binding regenerated cellulose. The membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free.

The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL. The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be directly injected with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

More Product Data
Separation characteristics of dialysis membranes

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Slide-A-Lyzer™ Cassette Syringes, 20 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer Dialysis Cassette Syringes are designed for efficiently loading samples into Slide-A-Lyzer cassettes and removing the sample after dialysis. The 20 mL syringes are a convenient size for use with 12 mL cassettes (66810, 66811)

These accessories are for use with Slide-A-Lyzer Dialysis Cassettes to remove low molecular weight contaminants and perform buffer exchange, desalting and concentration.

Features of Slide-A-Lyzer Dialysis Syringes:

• Matched to the Slide-A-Lyzer to minimize losses
• Chemically inert - will not contaminate product
• Appropriately sized for different sample volumes

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Slide-A-Lyzer™ G2 Dialysis Cassettes, 2K MWCO, 70 mL (Thermo Scientific™)

Thermo Scientific Slide-A-Lyzer G2 Dialysis Cassettes (2K MWCO) provide maximum convenience, flexibility and performance for sample dialysis.

Features of Slide-A-Lyzer G2 Dialysis Cassettes (2K MWCO):

Easy-loading—pipette-accessible for easy sample loading and retrieval
Self-floating—integrated air chambers eliminate the need for float buoys
Sturdy construction—ensures the highest possible sample integrity and protection
Superior design—thoroughly researched and tested to provide fast and consistent dialysis with maximum sample recovery
Multiple sizes—five cassette capacities to optimally match 0.25 to 70 mL sample volumes
Versatile—ideal for removing low molecular-weight contaminants, performing buffer exchange and desalting

The 2K molecular-weight cut off (MWCO) cassettes use a cellulose membrane that is rated to completely retain proteins and other macromolecules that are larger than 2000 daltons while allowing removal of buffer salts and small contaminants. The cassette membrane is composed of low-binding regenerated cellulose. The membranes and cassettes are manufactured using clean-room conditions to ensure that are contaminant-free.

The Slide-A-Lyzer G2 Dialysis cassettes are available in five precise membrane MWCOs (2K, 3.5K, 7K, 10K and 20K) for dialyzing sample volumes up to 70 mL. The Slide-A-Lyzer G2 Dialysis Cassettes allow samples to be directly injected with a syringe or with a pipette through the unique sample port. The Slide-A-Lyzer Cassette design allows air to be removed from inside the cassette to maximize the surface area-to-volume ratio, providing better dialysis performance than dialysis tubing and tube-based systems. The sample is easily recovered through either the pipette or syringe sample ports.

More Product Data
Separation characteristics of dialysis membranes

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