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IL1B Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 1, beta (IL1B) is a bioactive protein intended for use in cell culture applications. IL-1 is involved in a number of biological processes including the stimulation of T-helper cells, promotion proliferation and synthesis of immunoglobulins, and the activation of fibroblasts and NK cells.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 1, beta is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 1, beta (IL1B) specific activity is determined by the dose dependent proliferation of murine D10S cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL20 Recombinant Human Protein (Gibco™)

Recombinant IL20 is a bioactive protein intended for use in cell culture applications. There are two heterodimeric receptor complexes for IL20. The first is composed of IL20 Ra and IL20 Rb. The second is composed of IL-22 R and IL20b. IL20 induces the proliferation of multipotential hematopoietic progenitor cells, directs the differentiation and expansion of keratinocytes, and promotes the release of proinflammatory mediators in keratinocytes and other cells expressing the IL20 receptor.

TPO (Thrombopoietin), Recombinant Human Protein (Gibco™)

Recombinant Human Thrombopoietin (TPO) is a bioactive protein intended for use in cell culture applications. TPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, which is the product of the myeloproliferative leukemia virus oncogene. Recombinant Human Thrombopoeitin (TPO) is one of the many GIBCO® recombinant bioactive proteins available from Life Technologies. This is the 10 milligram size.

High purity—minimal interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—GIBCO® proteins bioassayed with GIBCO® media

High purity recombinant bioactive protein
Recombinant Human Thrombopoietin (TPO) is one of more than 250 GIBCO® recombinant proteins available from Life Technologies. To help ensure GIBCO® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to help ensure a biologically active protein.

High biological activity
In-house activity testing of Recombinant Human Thrombopoeitin (TPO) includes cell proliferation, cytotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, and protease assays. Recombinant Human Thrombopoietin (TPO) specific activity is determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Proven compatibility
GIBCO® proteins are bioassayed with GIBCO® media. Since 1962, GIBCO® has been a consistent provider of high quality media, reagents, and sera for reliable cell culture.

We also offer a selection of growth factors for use in cell therapy applications through our GIBCO® Cell Therapy Systems (CTS™) product line.

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

Related links
See our selection of recombinant GIBCO® growth factors.
Learn more about the GIBCO® Cell Therapy Systems (CTS™) product line.

VEGF Recombinant Human Protein (Gibco™)

Recombinant Human Vascular Endothelial Cell Growth Factor (VEGF) is a bioactive protein intended for use in cell culture applications. VEGF exerts angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. VEGF has also been shown to be chemotactic for monocytes and osteoblasts.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Vascular Endothelial Cell Growth Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Vascular Endothelial Cell Growth Factor (VEGF) specific activity is determined by the dose dependent proliferation of human umbilical vein cells (HUVEC).

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL21 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 21 (IL21) is a bioactive protein intended for use in cell culture applications. IL21 R, is a type I cytokine receptor and is most closely related to IL-2 Rb and IL-4 Ra. The IL21/IL21 R interaction appears to play important roles in B and T-cell proliferation after antigen stimulation and NK cell maturation.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 21 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 21 (IL21) specific activity is determined by the dose-dependent secretion of Interferon gamma by human natural killer lymphoma NK-92 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL2 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 2 (IL2) is a bioactive protein intended for use in cell culture applications. IL2 causes proliferation of T-cells and is a central regulator of immune responses.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 2 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 2 (IL2) specific activity is determined by the dose dependent proliferation of mouse CTLL-2 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

TNF Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Tumor Necrosis Factor-α (TNF) is a bioactive protein intended for use in cell culture applications. TNF causes cytolysis and cytostasis of many tumor cell lines. TNF has a wide spectrum of activities, including chemotaxis of neutrophils, alteration of the endothelium, inhibition of anticoagulatory mechanisms, and promotion of angiogenesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Tumor Necrosis Factor-α is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Tumor Necrosis Factor-α (TNF) specific activity is determined by the dose dependent cytotoxicity of L929 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

FLT3 Ligand Recombinant Human Protein (Gibco™)

Fms-Like Tyrosine Kinase 3 Ligand (FLT3 Ligand, FLT3LG) is a bioactive protein intended for use in cell culture applications. FLT3 Ligand is a cytokine involved in hematopoeisis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Fms-Like Tyrosine Kinase 3 Ligand is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Fms-Like Tyrosine Kinase 3 Ligand (FLT3 Ligand, FLT3LG) specific activity is determined by the dose dependent proliferation of human OCI-AML5 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

SDF1A Recombinant Human Protein (Gibco™)

Recombinant SDF1A is a bioactive protein intended for use in cell culture applications. SDF-1αis a small cytokine that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL-1.

BMP4 Recombinant Human Protein (Gibco™)

Recombinant Human Bone Morphogenetic Protein 4 (BMP4)is a bioactive protein intended for use in cell culture applications. BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Bone Morphogenetic Protein 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Bone Morphogenetic Protein 4 (BMP4)specific activity is determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

GDNF Recombinant Human Protein (Gibco™)

Glial-Derived Neurotrophic Factor (GDNF) is a bioactive protein intended for use in cell culture applications. GDNF is mainly known for its affect on neurons, but it is also involved in other biological processes including kidney development.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Glial-Derived Neurotrophic Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Glial-Derived Neurotrophic Factor (GDNF) specific activity is determined by inducing neurite outgrowth on PC-12 cells in the presence of recombinant soluble GFR-α.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

CNTF Recombinant Human Protein (Gibco™)

Ciliary Neurotropic Factor (CNTF) is a bioactive protein intended for use in cell culture applications. Cntf a cytokine involved in neuronal degeneration and adipocyte gene expression.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Ciliary Neurotropic Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Ciliary Neurotropic Factor (CNTF) specific activity is determined by measuring the dose-dependent proliferation of human TF-1 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

BMP7 Recombinant Human Protein (Gibco™)

Recombinant Human BMP7 is a bioactive protein intended for use in cell culture applications. BMP7 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta (TGF-β) superfamily. The TGF-β superfamily includes many families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo at an extraskeletal site. Recombinant Human BMP7 is one of the many GIBCO® recombinant bioactive proteins available from Life Technologies. This is the 10 microgram size.

High purity—minimal interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—GIBCO® proteins bioassayed with GIBCO® media

High purity recombinant bioactive protein
Recombinant BMP7 is one of more than 250 GIBCO® recombinant proteins available from Life Technologies. To help ensure GIBCO® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to help ensure a biologically active protein.

High biological activity
In-house activity testing includes a variety of cell proliferation, cytotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, and protease assays. Recombinant BMP7 specific activity is determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).

Proven Compatibility with GIBCO® Media
GIBCO® proteins are bioassayed with GIBCO® media. Since 1962 GIBCO® has been a consistent provider of high quality media, reagents, and sera for reliable cell culture.

We also offer a selection of growth factors for use in cell therapy applications through our GIBCO® Cell Therapy Systems (CTS™) product line.

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

Related links
See our selection of recombinant GIBCO® growth factors.
Learn more about the GIBCO® Cell Therapy Systems (CTS™) product line.

RANTES Recombinant Human Protein (Gibco™)

Recombinant RANTES is a bioactive protein intended for use in cell culture applications. RANTES functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. RANTES is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

IL6 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 6 (IL6) is a bioactive protein intended for use in cell culture applications. IL6 is a pleiotropic cytokine involved in several cellular processes including inflammation, hematopoeisis, and immune response.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 6 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 6 (IL6) specific activity is determined by the dose dependent proliferation of mouse B9 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL3 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 3 (IL3) is a bioactive protein intended for use in cell culture applications. IL3 provides the cytokine connection between the immune system and the hematopoietic system. For example, IL3 supports the proliferation and development of almost all types of hematopoietic progenitor cells and can act as a chemoattractant for eosinophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 3 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 3 (IL3) specific activity is determined by the dose dependent proliferation of human TF-1 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

SDF1B Recombinant Human Protein (Gibco™)

Recombinant SDF1B is a bioactive protein intended for use in cell culture applications. SDF1B is a small cytokine that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL-1.

FGF4 Recombinant Human Protein (Gibco™)

Recombinant Human Fibroblast Growth Factor 4 (FGF4) is a bioactive protein intended for use in cell culture applications. FGF4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Studies on the mouse homolog suggest a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Fibroblast Growth Factor 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Fibroblast Growth Factor 4 (FGF4) specific activity is determined by the dose dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL4 Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Interleukin 4 (IL4) is a bioactive protein intended for use in cell culture applications. IL4 promotes the proliferation and differentiation of activated B cells. In addition, IL4 up-regulates class II MHC antigen expression and IgE receptors.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Mouse Interleukin 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Interleukin 4 (IL4) specific activity is determined by measuring the dose-dependent proliferation of murine HT-2 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL6 Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Interleukin 6 (IL6) is a bioactive protein intended for use in cell culture applications. IL6 is a pleiotropic cytokine involved in several cellular processes including inflammation, hematopoeisis, and immune response.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Interleukin 6 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Interleukin 6 (IL6) specific activity is determined by the dose dependent proliferation of mouse B9 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

Activin A Recombinant Human Protein (Gibco™)

Recombinant Human Activin A is a bioactive protein intended for use in cell culture applications. Activin A is involved in multiple biological processes including inflammation, neural development, and haematopoiesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Activin A is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Activin A specific activity is determined by the dose dependent proliferation of mouse MPC-11 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL2 (Interleukin 2) CTS™ Recombinant Human Protein (Gibco™)

Cell Therapy Systems (CTS™) Recombinant Human Interleukin 2 (IL2) is a bioactive protein intended for use in cell culture applications, including pre-clinical and clinical cell therapy studies. IL2 causes proliferation of T cells and is a central regulator of immune responses. The lyophilized, E. coli-expressed IL2 CTS™ Recombinant Human is verified for activity through dose-dependent proliferation of mouse CTLL-2 cells.

Qualified—helps reduce your burden in qualifying reagents for regulatory submission in cell therapy applications
Highly Pure—minimizes interference from other proteins or contaminants
Active—get more results with less protein

Simplified Transition into Clinical Research
GIBCO® Cell Therapy Systems (CTS™) products are of high quality and supplied with harmonized documentation such as Certificates of Analysis, Certificates of Origin, and access to authorization letters for our Drug Master Files, as appropriate. The GIBCO® CTS™ product line enables you to reduce your burden in qualifying reagents during your transition from research applications to clinical applications.

High Purity
To help verify that GIBCO® CTS™ Recombinant growth factors are of the highest quality, each protein is analyzed for purity, along with structural homogeneity, to help ensure a biologically active protein. The purity of each GIBCO® CTS™ recombinant growth factor is verified by SDS-PAGE to be over 95% pure and to have endotoxin levels below 0.1 ng/μg.

High Biological Activity
All GIBCO® CTS™ Recombinant growth factors are verified for activity. Each lot has its own ED50 determined using an activity assay based on a specific function of the growth factor. The activity of our IL2 CTS™ Recombinant Human growth factor is determined by the dose dependent proliferation of mouse CTLL-2 cells to have an ED50 range of 0.08–0.5 ng/mL. Optimal concentration for individual applications should be determined by a dose response assay.

Related Links
Learn More About GIBCO® Cell Therapy Systems (CTS™) Products
Cell Therapy Systems Technical Support Web Page
Our Full Collection of GIBCO® CTS™ Growth Factors
Our Full Collection of GIBCO® Growth Factors

PDGF-BB Recombinant Human Protein (Gibco™)

Recombinant Human Platelet Derived Growth Factor-BB (PDGF-BB) is a bioactive protein intended for use in cell culture applications. Members of the PDGF family are mitogenic factors for cells of mesenchymal origin.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Platelet Derived Growth Factor-BB is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Platelet Derived Growth Factor-BB (PDGF-BB) specific activity is determined by the dose dependent proliferation of BALB/c 3T3 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

NT-4 Recombinant Human Protein (Gibco™)

Recombinant NT-4 is a bioactive protein intended for use in cell culture applications. NT-4 is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons.

CXCL1 (GROα) Recombinant Human Protein (Gibco™)

Recombinant Human Chemokine (C-X-C motif) ligand 1 (Also known as CXCL1, GROα, melanoma growth stimulating activity, MSGA, Neutrophil-activating protein 3, NAP-3) is a bioactive protein intended for use in cell culture applications. CXCL1 is a chemokine that induces the infiltration of neutrophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Chemokine (C-X-C motif) ligand 1 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Chemokine (C-X-C motif) ligand 1 (CXCL1, GROα) specific activity is determined by measuring the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

Oncostatin M Recombinant Human Protein (Gibco™)

Recombinant Human Oncostatin M (OSM) is a bioactive protein intended for use in cell culture applications. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Oncostatin M is a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Oncostatin M is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Oncostatin M (OSM) specific activity is determined by measuring the oncostatin M concentration dependent stimulation of proliferation of TF-1 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

SCF (C-Kit Ligand) Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Stem Cell Factor (SCF, C-Kit Ligand) is a bioactive protein intended for use in cell culture applications. SCF is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Stem Cell Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Stem Cell Factor (SCF, C-Kit Ligand) specific activity is determined by the dose dependent proliferation of human MO-7e cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

PDGF-BB Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Platelet Derived Growth Factor-BB (PDGF-BB) is a bioactive protein intended for use in cell culture applications. Members of the PDGF family are mitogenic factors for cells of mesenchymal origin.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Platelet Derived Growth Factor-BB is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Platelet Derived Growth Factor-BB (PDGF-BB) specific activity is determined by the dose-dependent proliferation of BALB/c 3T3 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

GM-CSF Recombinant Swine Protein (Gibco™)

Recombinant GM-CSF is a bioactive protein intended for use in cell culture applications. Recombinant swine GM-CSF is intended for use in cell culture applications. GM-CSF is involved in many biological responses including the growth and development of granulocyte and macrophage progenitor cells, stimulation and the initiation of differentiation of myeloblasts and monoblasts, and chemotaxis of eosinophils.

TNF Recombinant Human Protein (Gibco™)

Recombinant Human Tumor Necrosis Factor-α (TNF) is a bioactive protein intended for use in cell culture applications. TNF causes cytolysis and cytostasis of many tumor cell lines. TNF has a wide spectrum of activities, including chemotaxis of neutrophils, alteration of the endothelium, inhibition of anticoagulatory mechanisms, and promotion of angiogenesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Tumor Necrosis Factor-α is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Tumor Necrosis Factor-α (TNF) specific activity is determined by the dose dependent cytotoxic effect on L929 cells in the presence of actinomycin D.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL7 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 7 (IL7) is a bioactive protein intended for use in cell culture applications. IL7 stimulates the proliferation of pre-B and pro-B cells. IL7 also supports the maturation of megakaryocytes.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 7 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 7 (IL7) specific activity is determined by the dose dependent proliferation of human PBMCs.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IFN-γ Recombinant Human Protein (Gibco™)

Recombinant Human Interferon-γ (IFN-γ) is a bioactive protein intended for use in cell culture applications. IFN-γ is involved in many biological processes such as inducing the secretion of TNF-α and stimulating the release of reactive oxygen species from macrophages. It is also involved with bone growth and inhibits bone resorption. It is antiviral and antiparasitic and inhibits the proliferation of cells.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interferon-γ is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interferon-γ (IFN-γ) specific activity is determined by the dose dependent cytostasis of human WiDr cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

BDNF Recombinant Human Protein (Gibco™)

Recombinant Human Brain-Derived Neurotrophic Factor (BDNF) is a bioactive protein intended for use in cell culture applications. BDNF is a used in the maintenance of motor neurons and the differentiation of both cholinergic and dopaminergic neurons.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Brain-Derived Neurotrophic Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Brain-Derived Neurotrophic Factor (BDNF) specific activity is determined by measuring the dose-dependent induction of choline acetyl transferase activity in primary septal cell cultures.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL8 Monocyte Recombinant Human Protein (Gibco™)

Recombinant IL8 Monocyte is a bioactive protein intended for use in cell culture applications. IL8 is chemotactic for all known types of migratory immune cells. IL8 also inhibits the adhesion of leukocytes to activated endothelial cells.

FGF6 Recombinant Human Protein (Gibco™)

Recombinant human FGF6 is a bioactive protein intended for use in cell culture applications. FGF-16 is a member of the FGF family of proteins.

TPO Recombinant Mouse Protein (Gibco™)

Recombinant TPO is a bioactive protein intended for use in cell culture applications. TPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.

GM-CSF Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) is a bioactive protein intended for use in cell culture applications. GM-CSF is involved in many biological responses including the growth and development of granulocyte and macrophage progenitor cells, stimulation and the initiation of differentiation of myeloblasts and monoblasts, and chemotaxis of eosinophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Granulocyte Macrophage Colony-Stimulating Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) specific activity is determined by the dose dependent proliferation of MC/9 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

BMPR1A Recombinant Human Protein (Gibco™)

Bone Morphogenetic Protein Receptor 1A (BMPR1A) Fc Chimera is a bioactive protein intended for use in cell culture applications. BMPR1A is one of the bone morphogenetic protein (BMP) receptors which are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Bone Morphogenetic Protein Receptor 1A Fc Chimera is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Bone Morphogenetic Protein Receptor 1A (BMPR1A) specific activity is determined by its ability to inhibit human BMP4induction of alkaline phosphatase in the mouse chondrogenic cell line ATDC5.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

Soluble CD40L (TRAP) Recombinant Human Protein (Gibco™)

Recombinant Human soluble CD40 Ligand (sCD40L, TRAP) is a bioactive protein intended for use in cell culture applications. Soluble CD40L regulates B cell function by engaging CD40 on the B cell surface. This is the 10 microgram size.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human soluble CD40 Ligand is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human soluble CD40 Ligand (sCD40L, TRAP) specific activity is determined by measuring the dose-dependent stimulation of IL-12 production by isolated human PBMC's.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

BMP2 Recombinant Human Protein (Gibco™)

Recombinant Human Bone Morphogenetic Protein 2 (BMP2)is a bioactive protein intended for use in cell culture applications. BMP2is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. BMP2 acts as a disulfide-linked homodimer and induces bone and cartilage formation.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Bone Morphogenetic Protein 2 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Bone Morphogenetic Protein 2 (BMP2)specific activity is determined by the dose dependent induction of alkaline phosphatase in mouse chondrogenic cell line ATDC5.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

TNF Recombinant Human Protein, Liquid Form (Gibco™)

Recombinant Human Tumor Necrosis Factor-α (TNF) is a bioactive protein intended for use in cell culture applications. TNF causes cytolysis and cytostasis of many tumor cell lines. TNF has a wide spectrum of activities, including chemotaxis of neutrophils, alteration of the endothelium, inhibition of anticoagulatory mechanisms, and promotion of angiogenesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Tumor Necrosis Factor-α is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Tumor Necrosis Factor-α (TNF) specific activity is determined by the dose dependent cytotoxic effect on L929 cells in the presence of actinomycin D.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

FGF-Basic (AA 10-155) Recombinant Human Protein Solution (Gibco™)

FGF-Basic (AA 10-155) is a bioactive protein intended for use in cell culture applications. Fibroblast growth factor-basic is known as FGF-basic, bFGF, FGF 2, FGF-β, and heparin binding growth factor. FGF-basic is involved in a number of biological processes, including embryonic development and differentiation, neuron differentiation, survival, regeneration, and the proliferation of cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin.

Features of recombinant human FGF-basic:

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—proteins bioassayed with Gibco® media

High-purity, recombinant, bioactive protein
Human FGF-basic (AA 10-155) is one of our more than 250 available recombinant proteins. To help ensure our growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of recombinant proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant human FGF-basic specific activity is determined by the dose dependent proliferation of BALB/3T3 cells.

Proven compatibility
Our recombinant proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

TGFB1 Recombinant Human Protein (Gibco™)

Recombinant Human Transforming Growth Factor β 1 (TGFB1) is a bioactive protein intended for use in cell culture applications. TGFB1 is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB1 acts synergistically with TGF-α in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB1 activation and signaling may result in apoptosis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Transforming Growth Factor β 1 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Transforming Growth Factor β 1 (TGFB1) specific activity is determined by measuring the TGFB1 dose-dependent inhibition of proliferation of mouse HT-2 cells stimulated with mouse IL-4.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL7 Recombinant Mouse Protein (Gibco™)

Recombinant IL7 is a bioactive protein intended for use in cell culture applications. IL7 stimulates the proliferation of pre-B and pro-B cells. IL7 also supports the maturation of megakaryocytes.

IL8 Endothelial Recombinant Human Protein (Gibco™)

Recombinant IL8 Endothelial is a bioactive protein intended for use in cell culture applications. IL8 is chemotactic for all known types of migratory immune cells. IL8 also inhibits the adhesion of leukocytes to activated endothelial cells.

Sonic Hedgehog C25II Recombinant Mouse Protein (Gibco™)

Recombinant Sonic Hedgehog C25II is a bioactive protein intended for use in cell culture applications. Sonic Hedgehog is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites.

PDGF-AA Recombinant Human Protein (Gibco™)

Recombinant Human Platelet Derived Growth Factor-AA (PDGF-AA) is a bioactive protein intended for use in cell culture applications. Members of the PDGF family are mitogenic factors for cells of mesenchymal origin.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Platelet Derived Growth Factor-AA (PDGF-AA) is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Platelet Derived Growth Factor-AA (PDGF-AA) specific activity is determined by measuring the PDGF dose dependent proliferation of BALB/c 3T3 fibroblasts.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

RANTES Recombinant Rat Protein (Gibco™)

Recombinant RANTES is a bioactive protein intended for use in cell culture applications. RANTES functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. RANTES is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

IL4 (Interleukin 4) CTS™ Recombinant Human Protein (Gibco™)

Recombinant IL4 is a bioactive protein intended for use in cell culture applications. IL4 promotes the proliferation and differentiation of activated B cells. In addition, IL4 up-regulates class II MHC antigen expression and IgE receptors. ED50 = 0.05 to 0.4 ng⁄mL (Specific Activity: 2.0 x 10^7 to 2.5 x 10^6 units⁄mg). The biological activity is determined by measuring the dose-dependent proliferation of human TF-1 cells. A concentration range of 0.1 to 10.0 ng⁄mL is effective for most in vitro applications.

FGF-8b Recombinant Human Protein (Gibco™)

Recombinant Human Fibroblast Growth Factor 8 B (FGF-8B) is a bioactive protein intended for use in cell culture applications. FGF-8b is one of the isoforms of FGF-8, and is involved in many biological processes including angiogenesis.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Fibroblast Growth Factor 8 B is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Fibroblast Growth Factor 8 B (FGF-8B) specific activity is determined by the dose dependent proliferation of BALB/3T3 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

SCF (C-Kit Ligand) CTS™ Recombinant Human Protein (Gibco™)

Cell Therapy Systems CTS™ Recombinant Human Stem Cell Factor (SCF) is a bioactive protein intended for use in cell culture applications, including pre-clinical and clinical cell therapy studies. SCF is a pleiotropic factor that acts in utero in germ cell and neural cell development and hematopoiesis. These activities are all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. The lyophilized, E. coli-expressed SCF CTS™ Recombinant Human is verified for activity through dose-dependent proliferation of human MO-7e cells.

Qualified—helps reduce your burden in qualifying reagents for regulatory submission in cell therapy applications
Highly Pure—minimizes interference from other proteins or contaminants
Active—get more results with less protein

Simplified Transition into Clinical Research
GIBCO® CTS™ products are of high quality and supplied with harmonized documentation such as Certificates of Analysis, Certificates of Origin, and access to authorization letters for our Drug Master Files, as appropriate. The GIBCO® CTS™ product line enables you to reduce your burden in qualifying reagents during your transition from research applications to clinical applications.

High Purity
To help verify that GIBCO® CTS™ Recombinant growth factors are of the highest quality, each protein is analyzed for purity, along with structural homogeneity, to help ensure a biologically active protein. The purity of each GIBCO® CTS™ recombinant growth factor is verified by SDS-PAGE to be over 95% and to have endotoxin levels below 0.1 ng/μg.

High Biological Activity
All GIBCO® CTS™ Recombinant growth factors are verified for activity. Each lot has its own ED50 determined using an activity assay based on a specific function of the growth factor. The activity of our SCF CTS™ Recombinant Human growth factor is determined by the dose-dependent proliferation of human MO-7e cells to have an ED50 range of 2–10 ng/mL (specific activity: 5 × 105–1 × 105 units/mg). Optimal concentration for individual applications should be determined by a dose response assay.

Related Links
Learn More About GIBCO® Cell Therapy Systems (CTS™) Products
Cell Therapy Systems Technical Support Web Page
Our Full Collection of GIBCO® CTS™ Growth Factors
Our Full Collection of GIBCO® Growth Factors

TGFA Recombinant Human Protein (Gibco™)

Recombinant TGFA is a bioactive protein intended for use in cell culture applications. TGFA shows about 40% sequence homology with epidermal growth factor and competes with EGF for binding to the EGF receptor, stimulating its phosphorylation and producing a mitogenic response.

IL2 Recombinant Mouse Protein (Gibco™)

Recombinant IL-2 is a bioactive protein intended for use in cell culture applications. IL-2 causes proliferation of T cells and is a central regulator of immune responses.

VEGF Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Vascular Endothelial Cell Growth Factor (VEGF) is a bioactive protein intended for use in cell culture applications. VEGF exerts angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. VEGF has also been shown to be chemotactic for monocytes and osteoblasts.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Vascular Endothelial Cell Growth Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Vascular Endothelial Cell Growth Factor (VEGF) specific activity is determined by the dose dependent proliferation of human umbilical vein cells (HUVEC).

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

HGF Recombinant Human Protein (Gibco™)

Recombinant Human Hepatocyte Growth Factor (HGF) is a bioactive protein intended for use in cell culture applications. HGF plays a role in positive regulation of cell proliferation.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Hepatocyte Growth Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Hepatocyte Growth Factor (HGF) specific activity is determined by the dose dependent proliferation of monkey 4MBr-5 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

NT-3 Recombinant Human Protein (Gibco™)

Recombinant NT-3 is a bioactive protein intended for use in cell culture applications. NT-3 is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta.

GM-CSF Recombinant Human Protein, Animal Origin Free (Gibco™)

Recombinant Human Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) is a bioactive protein intended for use in cell culture applications. GM-CSF is involved in many biological responses including the growth and development of granulocyte and macrophage progenitor cells, stimulation and the initiation of differentiation of myeloblasts and monoblasts, and chemotaxis of eosinophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Granulocyte Macrophage Colony-Stimulating Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) specific activity is determined by the dose dependent proliferation of human TF-1 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL4 Recombinant Human Protein (Gibco™)

Recombinant Human Interleukin 4 (IL4) is a bioactive protein intended for use in cell culture applications. IL4 promotes the proliferation and differentiation of activated B cells. In addition, IL4 up-regulates class II MHC antigen expression and IgE receptors.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 4 (IL4) specific activity is determined by measuring the dose-dependent proliferation of human TF-1 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

M-CSF Recombinant Mouse Protein (Gibco™)

Recombinant Mouse Macrophage Colony-Stimulating Factor (M-CSF) is a bioactive protein intended for use in cell culture applications. M-CSF is induces proliferation and differentiation of hematopoietic stem cells into macrophages and growth and differentiation of monocytes.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Macrophage Colony-Stimulating Factor is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Macrophage Colony-Stimulating Factor (M-CSF) specific activity is determined by the dose dependent proliferation of murine M-NFS-60 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

IL8 Recombinant Swine Protein (Gibco™)

Recombinant IL8 is a bioactive protein intended for use in cell culture applications. IL8 is chemotactic for all known types of migratory immune cells. IL8 also inhibits the adhesion of leukocytes to activated endothelial cells.