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Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO Thermo Scientific™

Thermo Scientific RED Device 8K MWCO Inserts are single-use, disposable inserts made up of two side-by-side chambers separated by a vertical cylinder of dialysis membrane in 8K MWCO, validated for minimal nonspecific binding.

Features of RED Device 8K MWCO Inserts:

Disposable: require no presoaking, assembly, or specialized equipment
Short incubation time: large dialysis surface area accelerates equilibrium
8K MWCO membrane: ideal molecular-weight cutoff for protein-drug binding studies
Membrane composition: regenerated cellulose with low glycerol content as a humectant

This format requires no extensive assembly steps or specialized equipment, and each chamber or well is easily accessible from the top of the insert after insertion in the base plate. Additionally, the high surface-to-volume ratio of the membrane compartment allows rapid dialysis, where equilibrium can be reached in 4 hours with high levels of reproducibility and accuracy. In many cases, experiments can be completed in less than 100 minutes.

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Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Reusable Base Plate
Rapid Equilibrium Dialysis (RED) Device Single-Use Base Plates
Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool
Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 12K MWCO

Rapid Equilibrium Dialysis (RED) Device Reusable Base Plate Thermo Scientific™

Thermo Scientific RED Device Single-Use Base Plates hold up to 48 RED Device Inserts and have a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems.

Features of the RED Device Single-Use Base Plates:

• Microplate footprint: compatible with automated systems for 96-well plates
• Compartmentalized: eliminates potential for crosstalk or leakage
• PTFE construction: eliminates nonspecific binding and risk of contamination
• Accepts 1 to 48 inserts: run exactly the number of assays needed without waste
• Easily disposed of to avoid contamination and cleaning

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Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Single-Use Base Plates
Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool
Competition Rapid Equilibrium Dialysis (RED) Base Plate

Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool Thermo Scientific™

The Thermo Scientific RED Device Insert Removal Tool is made of stainless steel and is used for removing columns of RED Inserts from RED Base Plates.

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Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 12K MWCO

Rapid Equilibrium Dialysis (RED) Device Single-Use Base Plates Thermo Scientific™

Thermo Scientific RED Device Single-Use Base Plates hold up to 48 RED Device Inserts and have a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems.

Features of the RED Device Single-Use Base Plates:

• Microplate footprint: compatible with automated systems for 96-well plates
• Compartmentalized: eliminates potential for crosstalk or leakage
• PTFE construction: eliminates nonspecific binding and risk of contamination
• Accepts 1 to 48 inserts: run exactly the number of assays needed without waste
• Easily disposed of to avoid contamination and cleaning

Related Products
Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Reusable Base Plate
Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool
Competition Rapid Equilibrium Dialysis (RED) Base Plate

Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO Thermo Scientific™

The Thermo Scientific Pierce RED Device for Rapid Equilibrium Dialysis provides the easiest, fastest and most reliable system for performing plasma protein-binding assays, a critical step in drug development. This product includes a single-use plate with 8K MWCO inserts.

Features of the RED Device for Rapid Equilibrium Dialysis:

Easy and ready to use—disposable tubes require no presoaking, assembly or specialized equipment
Designed for speed—the high surface-to-volume ratio of the insert design enables equilibrium to be reached in as few as 100 minutes with vigorous agitation or in three to four hours with 200rpm agitation
Automation-compatible—designed on a standard 96-well plate template suitable for automated liquid handlers
Flexible and scalable—perform any number of assays (1 to 48 assays per plate) without wasting the entire plate
Robust—compartmentalized design eliminates potential for cross talk or leakage
Reproducible and accurate—validated for plasma binding assays, producing results consistent with those reported in literature
Quality-tested—each lot of inserts is functionally tested in a protein-binding assay for guaranteed performance

The Pierce Device for rapid equilibrium dialysis (RED) was developed in association with the pharmaceutical industry to provide the easiest, fastest and most reliable system for performing plasma protein-binding assays.

The RED Device is an apparatus for performing equilibrium dialysis experiments in a high throughput, automation-compatible format, and consists of disposable inserts and a base plate formatted to a standard microplate footprint. It has been extensively validated for plasma-binding assays and produces results consistent with those reported in the literature. The RED Device also offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available equilibrium dialysis systems.

Features of the RED Device Inserts:
Each single-use, disposable insert is made of two side-by-side chambers separated by a vertical cylinder of dialysis membrane (in 8K or 12K MWCO) validated for minimal nonspecific binding. This format requires no extensive assembly steps or specialized equipment, and each chamber or well is easily accessible from the top of the insert after insertion in the base plate. Additionally, the high surface-to-volume ratio of the membrane compartment allows rapid dialysis, where equilibrium can be reached in 4 hours with high levels of reproducibility and accuracy. In many cases, experiments can be completed in less than 100 minutes.

Insert Features:
• Disposable: require no presoaking, assembly, or specialized equipment
• Short incubation time: large dialysis surface area accelerates equilibrium
• 8K MWCO membrane: ideal molecular-weight cutoff for protein-drug binding studies
• 12K MWCO membrane also available for larger drug molecules
• Membrane composition: regenerated cellulose with low glycerol content as a humectant

Features of the RED Device Base Plates:
RED Device Inserts are designed to be used with either the reusable PTFE or disposable high-density polypropylene base plates. Each RED Device Base Plate holds up to 48 RED Device Inserts and has a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems. In addition, the disposable RED Device Base Plates are available pre-loaded, providing operation convenience for scientists conducting protein-binding applications. No pre-conditioning of the membrane inserts is needed. When using radioactive materials, this single-use plate is easily disposed of to avoid contamination and cleaning. RED Device Inserts an

Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 12K MWCO Thermo Scientific™

The Thermo Scientific Pierce RED Device for Rapid Equilibrium Dialysis provides the easiest, fastest and most reliable system for performing plasma protein-binding assays, a critical step in drug development. This product includes 10 single-use plates with 12K MWCO inserts.

Features of the RED Device for Rapid Equilibrium Dialysis:

Easy and ready to use—disposable tubes require no presoaking, assembly or specialized equipment
Designed for speed—the high surface-to-volume ratio of the insert design enables equilibrium to be reached in as few as 100 minutes with vigorous agitation or in three to four hours with 200rpm agitation
Automation-compatible—designed on a standard 96-well plate template suitable for automated liquid handlers
Flexible and scalable—perform any number of assays (1 to 48 assays per plate) without wasting the entire plate
Robust—compartmentalized design eliminates potential for cross talk or leakage
Reproducible and accurate—validated for plasma binding assays, producing results consistent with those reported in literature
Quality-tested—each lot of inserts is functionally tested in a protein-binding assay for guaranteed performance

The Pierce Device for rapid equilibrium dialysis (RED) was developed in association with the pharmaceutical industry to provide the easiest, fastest and most reliable system for performing plasma protein-binding assays.

The RED Device is an apparatus for performing equilibrium dialysis experiments in a high throughput, automation-compatible format, and consists of disposable inserts and a base plate formatted to a standard microplate footprint. It has been extensively validated for plasma-binding assays and produces results consistent with those reported in the literature. The RED Device also offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available equilibrium dialysis systems.

Features of the RED Device Inserts:
Each single-use, disposable insert is made of two side-by-side chambers separated by a vertical cylinder of dialysis membrane (in 8K or 12K MWCO) validated for minimal nonspecific binding. This format requires no extensive assembly steps or specialized equipment, and each chamber or well is easily accessible from the top of the insert after insertion in the base plate. Additionally, the high surface-to-volume ratio of the membrane compartment allows rapid dialysis, where equilibrium can be reached in 4 hours with high levels of reproducibility and accuracy. In many cases, experiments can be completed in less than 100 minutes.

Insert Features:
• Disposable: require no presoaking, assembly, or specialized equipment
• Short incubation time: large dialysis surface area accelerates equilibrium
• 8K MWCO membrane: ideal molecular-weight cutoff for protein-drug binding studies
• 12K MWCO membrane also available for larger drug molecules
• Membrane composition: regenerated cellulose with low glycerol content as a humectant

Features of the RED Device Base Plates:
RED Device Inserts are designed to be used with either the reusable PTFE or disposable high-density polypropylene base plates. Each RED Device Base Plate holds up to 48 RED Device Inserts and has a standard 96-well plate footprint with 9mm x 9mm well spacing to provide compatibility with automated liquid handling systems. In addition, the disposable RED Device Base Plates are available pre-loaded, providing operation convenience for scientists conducting protein-binding applications. No pre-conditioning of the membrane inserts is needed. When using radioactive materials, this single-use plate is easily disposed of to avoid contamination and cleaning. RED Device Inserts and Base Plates are also available separately.

Base Plate Features:
• Microplate footprint: compatible with automated systems for 96-well plates
• Compartmentalized: eliminates potential for crosstalk or leakage
• PTFE construction: eliminates nonspecific binding and risk of contamination
• Accepts 1 to 48 inserts: run exactly the number of assays needed without waste

Applications:
• Determination of free vs. drug bound to plasma proteins
• Pharmacokinetics studies
• Formulation of drug dosage for in vivo studies
• Drug-drug interaction studies
• Selection criteria during drug lead optimization
• Drug partition between plasma and whole blood
• Solubility study
• Dissociation constant determination (Kd)
• Tissue-binding study using tissue homogenate

Determining the extent to which a molecule binds to plasma proteins is a critical phase of pharmaceutical development because it influences compound dosing, drug efficacy, clearance rate and potential for drug interactions. This determination is enabled by equilibrium dialysis, an accepted standard method for reliable estimation of the nonbound drug fraction in plasma. Although it is the preferred method, equilibrium dialysis is generally labor-intensive, time-consuming, cost-prohibitive and difficult to automate. The RED Device for rapid equilibrium dialysis was developed in close association with the pharmaceutical industry to specifically address these issues, accelerating lead optimization and reducing the attrition rate. In addition to plasma protein binding, the device is used for determining drug partition between red blood cell and plasma, protein binding of liver microsomes to improve the correlation between in vitro and in vivo intrinsic clearance, the competition between tissue protein binding against plasma proteins and dissociation constant determination (Kd).

The RED Device has been extensively validated for plasma-binding assays producing results consistent with those reported in the literature. For example, when used to measure warfarin binding to plasma (human and rat) proteins at two concentrations of 1 µM and 10 µM, the RED Device produced results with minimal intra-experimental variability. The Rapid Equilibrium Dialysis (RED) Device offers significant improvements in automation, time requirements, versatility and product reliability compared to other commercially available systems.

Related Products
Rapid Equilibrium Dialysis (RED) Device Reusable Base Plate
Rapid Equilibrium Dialysis (RED) Device Single-Use Base Plates
Rapid Equilibrium Dialysis (RED) Device Insert Removal Tool
Rapid Equilibrium Dialysis (RED) Device Single-Use Plate with Inserts, 8K MWCO
Rapid Equilibrium Dialysis (RED) Device Inserts, 8K MWCO

Competition Rapid Equilibrium Dialysis (RED) Inserts Thermo Scientific™

Thermo Scientific Pierce Competition RED Device Inserts and Base Plates comprise a specially designed system for evaluating competitive binding interactions using rapid equilibrium dialysis (RED).

The Competition RED Device was developed in association with pharmaceutical laboratories to more accurately model in vivo drug interactions by enabling equilibrium dialysis experiments to be performed in a multiplexed format involving competition for binding among different tissues. The Competition RED Device System consists of disposable dialysis tube inserts and a reusable Base Plate made of high-grade PTFE. The Base Plate is much like our regular RED Device Plate except that it is divided into different size chambers (wells) for positioning 2-8 RED Device Inserts per well. The format enables competitive dialysis experiments involving 2-15 separate tissue or protein fluid samples. Each Competition RED Insert contains either one or two separate dialysis chambers (each package includes a selection of both types). The Competition RED Device requires no extensive assembly or specialized equipment, and each chamber/well is easily accessible from the top of the device.

Features of the Competition Rapid Equilibrium Dialysis (RED) Device:

Easy to use—disposable tubes require no presoaking step, assembly, or specialized equipment
Short incubation time—design provides high surface-to-volume ratio of membrane to sample, enabling equilibrium to be reached within 2-4 hours
Flexible format—base plate contains several different chamber sizes, enabling small molecule partitioning studies involving 2-16 tissue or protein samples without waste
Robust—compartmentalized design eliminates potential for cross talk or leakage
Reproducible and accurate—perform controlled experiments with multiple tissues to obtain screening results that have high predictability for in vivo studies with animal models
Validated quality—base plate is composed of chemically inert high-grade PTFE, eliminating non-specific binding and risk of contamination; each lot is functionally tested in a protein binding assay for guaranteed performance

Applications:
• ADME-Tox studies: in vitro screening of drug partitioning between plasma and multiple tissues before in vivo studies with animal models
• Aids in determining formulation of drug dosage for in vivo studies
• Drug-drug interaction studies
• Competitive binding and dissociation constant determination for small molecules versus multiple targets

Determining the extent to which a molecule partitions between plasma and specific tissues in the body is a critical phase of drug development because it determines compound dosing, efficacy, clearance rate, and the potential for drug interactions or tissue damage. Although final assessment of these variables invariably requires animal dosing and analysis, in vitro screening systems that are rapid and have good predictability are highly desirable for ADME-Tox studies. Equilibrium dialysis is among the most successful of in vitro screening method for evaluating drug binding and dosage requirements. Equilibrium dialysis is used to estimate the non-bound drug fraction in plasma or drug partitioning between red blood cell and plasma, plasma and liver microsomes, or plasma and tissue homogenates. However, many tissue-partitioning studies indicate that certain drugs show significant binding to tissues tested individually but have considerably different binding preferences when placed in competition between multiple tissues. The Competition RED Device extends the power of equilibrium dialysis by facilitating analysis of simultaneous drug interactions and partitioning among multiple tissues.

Posters:
• (Xia, C. et al.)
• (Qian, M.G., et al.)
• (Matuszak, K. and Custer, C.)

Related Products
Competition Rapid Equilibrium Dialysis (RED) Base Plate

Competition Rapid Equilibrium Dialysis (RED) Base Plate Thermo Scientific™

Thermo Scientific Pierce Competition RED Device Inserts and Base Plates comprise a specially designed system for evaluating competitive binding interactions using rapid equilibrium dialysis (RED).

The Competition RED Device was developed in association with pharmaceutical laboratories to more accurately model in vivo drug interactions by enabling equilibrium dialysis experiments to be performed in a multiplexed format involving competition for binding among different tissues. The Competition RED Device System consists of disposable dialysis tube inserts and a reusable Base Plate made of high-grade PTFE. The Base Plate is much like our regular RED Device Plate except that it is divided into different size chambers (wells) for positioning 2-8 RED Device Inserts per well. The format enables competitive dialysis experiments involving 2-15 separate tissue or protein fluid samples. Each Competition RED Insert contains either one or two separate dialysis chambers (each package includes a selection of both types). The Competition RED Device requires no extensive assembly or specialized equipment, and each chamber/well is easily accessible from the top of the device.

Features of the Competition Rapid Equilibrium Dialysis (RED) Device:

Easy to use—disposable tubes require no presoaking step, assembly, or specialized equipment
Short incubation time—design provides high surface-to-volume ratio of membrane to sample, enabling equilibrium to be reached within 2-4 hours
Flexible format—base plate contains several different chamber sizes, enabling small molecule partitioning studies involving 2-16 tissue or protein samples without waste
Robust—compartmentalized design eliminates potential for cross talk or leakage
Reproducible and accurate—perform controlled experiments with multiple tissues to obtain screening results that have high predictability for in vivo studies with animal models
Validated quality—base plate is composed of chemically inert high-grade PTFE, eliminating non-specific binding and risk of contamination; each lot is functionally tested in a protein binding assay for guaranteed performance

Applications:
• ADME-Tox studies: in vitro screening of drug partitioning between plasma and multiple tissues before in vivo studies with animal models
• Aids in determining formulation of drug dosage for in vivo studies
• Drug-drug interaction studies
• Competitive binding and dissociation constant determination for small molecules versus multiple targets

Determining the extent to which a molecule partitions between plasma and specific tissues in the body is a critical phase of drug development because it determines compound dosing, efficacy, clearance rate, and the potential for drug interactions or tissue damage. Although final assessment of these variables invariably requires animal dosing and analysis, in vitro screening systems that are rapid and have good predictability are highly desirable for ADME-Tox studies. Equilibrium dialysis is among the most successful of in vitro screening method for evaluating drug binding and dosage requirements. Equilibrium dialysis is used to estimate the non-bound drug fraction in plasma or drug partitioning between red blood cell and plasma, plasma and liver microsomes, or plasma and tissue homogenates. However, many tissue-partitioning studies indicate that certain drugs show significant binding to tissues tested individually but have considerably different binding preferences when placed in competition between multiple tissues. The Competition RED Device extends the power of equilibrium dialysis by facilitating analysis of simultaneous drug interactions and partitioning among multiple tissues.

Posters:
• (Xia, C. et al.)
• (Qian, M.G., et al.)
• (Matuszak, K. and Custer, C.)

Related Products
Competition Rapid Equilibrium Dialysis (RED) Inserts
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