The combination of chemical fixation procedures with high pressure freezing and freeze substitution preserves highly labile tissue ultrastructure for electron tomography applications.

Citations & References

  • Authors: Sosinsky GE, Crum J, Jones YZ, Lanman J, Smarr B, Terada M, Martone ME, Deerinck TJ, Johnson JE, Ellisman MH,
  • Journal: J Struct Biol (2008) 161:359-371
  • PubMed ID: 17962040