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This webinar highlights the operational, quality, and efficiency benefits of integrating real-time Process Raman spectroscopy into pharmaceutical manufacturing, specifically during Hot Melt Extrusion (HME). Attendees will learn how spectroscopy can support:
- Real-Time Monitoring: Raman enables immediate adjustments for optimal product quality
- Consistent Quality Assurance: Raman ensures stable API forms and prevents degradation
- Accurate Quantification: Raman is validated by HPLC, providing precise API concentration predictions
- Enhanced Efficiency: Raman improves the reliability and efficiency of the HME process
- Valuable Insights: Raman offers detailed understanding of API-polymer interactions
The session is designed for pharmaceutical professionals aiming to improve manufacturing processes and deliver high-quality products through advanced process monitoring technologies.
By attending this webinar, you will learn:
- How advanced process analytical technologies (PAT) can transform pharmaceutical manufacturing at criticial points.
- The value of real-time process monitoring for improving product quality and efficiency.
- Optimizing manufacturing processes to achieve superior product outcomes.
About the webinar speakers
Keith Freel
Keith Freel, PhD is an analytical chemist with extensive experience in pharmaceutical research and development. He currently serves as the Research Project Director at the University of Maryland Baltimore, School of Pharmacy, where he supports the UMB GMP facility. Additionally he leads research studies under Dr. Stephen Hoag. His research interests include advanced pharmaceutical manufacturing methods such as 3D printing, hot melt extrusion (HME), process analytical technologies (PAT), as well as the application of spectroscopy in pharmaceutical research and product development. Prior to his current role, he spent ten years at Metrohm and Thermo Fisher Scientific, where he held various scientific roles to support the pharmaceutical industry. He earned his Ph.D. in Chemistry from Emory University, where he conducted research in spectroscopy and molecular energy transfer processes
Nimesh Khadka
Nimesh Khadka, PhD is a senior application scientist with at Thermo Fisher Scientific with specializing in analytical biochemistry, spectroscopy, and chemometrics. With more than 5 years of experience in process development and PAT, he currently champions Raman spectroscopy as a PAT for development of biotherapeutics therapeutics. Nimesh completed his PhD at Utah State University focusing on enzymology, spectroscopy, and alternative bioenergy. In his postdoctoral training at Case Western Reserve University, Nimesh focused on the study of structural biology in biomolecules associated with eye pathologies. Through this extensive background, Nimesh has a deep understanding of the intricacies of biomolecular structures and their broad applications.