Tradeshow
Nov 14, 2023 - Nov 18, 2023
Salt Lake City, UT

Thermo Fisher Scientific will be a Gold Partner at the upcoming Association for Molecular Pathology (AMP) 2023 annual meeting in Salt Lake City, UT, November 14-18. We look forward to connecting with you at Booth 1319 and during our sessions at the Reference Materials Forum, Corporate Workshops, and Scientific Poster presentations.

A select number of our corporate workshops and scientific posters are available to view on demand.

Access here


AMP Reference Materials Forum

November 14, 2023

The human microbiome is receiving significant attention given its critical roles in the maintenance of human health. The compositional and functional alterations of the human microbiota could lead to various pathological conditions. However, microbial composition profiling techniques can suffer from bias and errors during many steps of the workflow, which may cause the variation in compositional measurements between laboratories. Quality control materials are ideal materials to identify sources of variation in microbiome research and product development since they are characterized by sufficiently homogeneous and stable properties, and provide essential elements to verify, validate and monitor test performance (both instruments and assays), technical and non-technical variation of workflows. This scientific talk would like to bring up the awareness on the microbiome control materials with the focus on the following topics: 1) microbiome background, 2) current microbiome profiling techniques, 3) the perspectives for choosing the appropriate microbiome control materials, 4) the current challenges for microbiome control materials, 5) and the emerging strategies of quality control materials for microbiome field.

Speaker: Qiang Gan, PhD
R&D Staff Scientist, Thermo Fisher Scientific

Sourcing the QC materials derived from clinical specimens is severely hampered by biosafety concerns, high cost, limited availability, and transport/trade issues, etc. To overcome these challenges, a recombinant MS2-PLP (MS2-Phage-Like Particle) capable of display multiple pathogen target sequences has been developed. Recombinant MS2-PLPs are highly engineerable, non-infectious, scale-up friendly, and cost effective, which constitutes invaluable tools to support the development, validation, and routine performance and quality monitoring of molecular diagnostic assay. The freedom of designing and developing reference materials allows the commutability between laboratories, to achieve the goal of harmonization and standardization of lab procedures and to establish traceability to a reference system.

Speaker: Hui Wang, PhD
Manager, Molecular Biology, Thermo Fisher Scientific


Corporate workshops

November 15, 2023
Room 253AB

Recent years have seen advances in automation that have brought Next-Generation Sequencing (NGS) out of specialized reference laboratories and into local pathology departments. This innovation has allowed biomarker assessment to take place “in-house”, facilitating shorter turnaround times and more efficient use of laboratory resources. During this workshop, hear how one lab with no previous NGS experience was able to adopt a rapid, amplicon-based NGS profiling assay via an automated semi-conductor sequencing system. Also, learn how other institutions are leveraging rapid, end-to-end NGS to augment existing laboratory workflows.

Speakers:
Allison Eck, MS, HTL(ASCP), Director, Pathology and Laboratory Medicine, Doylestown Hospital
Sean Glenn, PhD, Vice Chair Molecular Pathology & Clinical Director, Genomics Shared Resource, Roswell Park Comprehensive Cancer Center

The future of molecular profiling requires fast turnaround time for an increasingly large number of genetic biomarkers. Rapid next-generation sequencing (NGS) is helping to accelerate these critical insights by enabling test results to be available in as little as a single day. During this workshop, see how rapid NGS is helping to facilitate swift patient enrollment into a clinical trial aiming to investigate the effectiveness of various therapeutic agents based on genetic testing results. Also, learn how NGS technology is advancing measurable residual disease (MRD) analysis by detecting low-frequency variants with high sensitivity across a broad number of genes simultaneously.

Speakers:
Cecilia Yeung, MD, Associate Professor & Medical Director, Clinical Testing Labs,Fred Hutchinson Cancer Center
Lauren Frady, MS, MB(ASCP), Staff Scientist, Assay Development, Q2 Solutions

As the number of relevant oncology biomarkers has increased over the last decade, so has the use of comprehensive genomic profiling (CGP) for molecular characterization of solid tumors. CGP allows for simultaneous assessment of thousands of variants across hundreds of genes, as well as evaluation of complex biomarkers such as homologous recombination deficiency (HRD), tumor mutation burden (TMB), and microsatellite instability (MSI). In this workshop, hear how one research laboratory is leveraging the Oncomine Comprehensive Assay Plus (OCA+) to perform CGP in-house. Additionally, see results from a multi-site study evaluating performance of OCA+ across several parameters.

Speakers:
Yi Ding, MD, PhD, Director, System and Core Lab, Molecular Diagnostics, Geisinger Medical Laboratories
Jose Luis Costa, PhD, BCMAS, Director, Scientific Affairs, Clinical Next-Generation Sequencing, Thermo Fisher Scientific

Efficient and accurate sample analysis plays a crucial role in advancing cancer research and optimizing workflows. This presentation emphasizes the importance of efficient and accurate sample analysis in cancer research and workflow optimization. We explore the benefits of leveraging streamlined, scalable workflows for sample processing and digital PCR analysis. Using a modular approach, researchers simplify sample extraction and integrate with high-throughput digital PCR solutions. Additionally, accurate digital PCR and unique assay design helps enable multiplexing of targets, providing more comprehensive information from limited materials. These advancements help contribute to the progress of liquid biopsy research.

Speakers:
Christie Fekete, Senior Manager, Product Management, dPCR, Thermo Fisher Scientific
Christian Kis, Field Application Staff Scientist, Thermo Fisher Scientific

With the continued growth in the field of liquid biopsies, this less-invasive sample type is revolutionizing the way we perceive cancer research, and progression monitoring. Join researchers from The University of Leicester, Leicester Cancer Research Center, sharing their experience in oncology research, including work using liquid biopsy with automation enablement and subsequent molecular analysis.

Speaker:
Dr. Rebecca Allsopp, Postdoctoral Research Associate, Leicester Cancer Research Centre

During this session, we will present two new product offers from Thermo Fisher Scientific. First, a new direct RT-qPCR system that can be used to amplify nucleic acid from inhibitor-enriched samples. Our latest data demonstrates new reagents and workflow conditions that work best on saliva and serum samples.

Second, the new Invitrogen Lyo-ready bst DNA Polymerase for (RT)-LAMP isothermal amplification. This best-in-class enzyme demonstrates the highest speed, sensitivity, and resistance to inhibitor performance in LAMP reactions. Together the lyo-ready SuperScript IV reverse transcriptase and lyo-ready RNaseOUT Rnase Inhibitors offer the fastest solution for pathogen diagnostics using RT-LAMP.

Speaker:
Jūratė Zujienė, Product Manager, Thermo Fisher Scientific

Room 251E

Join us in Salt lake City, Utah, at AMP 2023, for a conversation with Amanda Hancock and Greg Behringer from Genesis Laboratory Management, LLC. They will discuss implementing syndromic testing for enteric pathogens, selecting clinically relevant targets like Clostridioides difficile, and incorporating genotypic antimicrobial resistance into panel workflows.

Speakers:
Amanda Hancock, Laboratory Operations Manager, Genesis Laboratory Management
Greg Behringer, Molecular Biologist, Genesis Laboratory Management

Join us at AMP 2023, where Dr.Vijay Singh, Vice President of HealthTrackRx, a leading molecular PCR-based infectious disease laboratory, will discuss the development and validation of a laboratory developed, multiplex real-time PCR test for the detection of Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), Mycoplasma genitalium (MG), Trichomonas vaginalis (TV) on two separate PCR platforms. He will show how the test displayed high accuracy, sensitivity, and specificity for the tested pathogens in different patient sample types. In addition, Dr. Singh will discuss the viability of using urine, a non-invasive sample type, for testing STIs.

Speaker: 
Vijay Singh, PhD, Vice President, Research and Development, HealthTrackRx

Moderator: 
Teddie Proctor, Senior Manager, Clinical Affairs, Thermo Fisher Scientific

Standardized molecular testing is critical for research laboratories to rapidly evaluate to evolving public health needs. Gain insights from an expert led demonstration of Thermo Fisher Scientific workflow integration using Diomni software, that provides value for every workflow in error reduction, shortened time to results, and infectious disease and pharmacogenomics test menu scalability. From sample preparation to qPCR analysis leverage with simplified data management, result tracking, and LIMS/LIS integration. As the world leader in serving science, Thermo Fisher Scientific is committed to provide innovative, and adaptable systems needed for laboratories to expand their molecular testing needs and prepare for the future.

Speaker: 
Brunie White, Field Application Scientist, Thermo Fisher Scientific

Chromosomal Microarray is currently the first-tier test for identifying genomic copy number variants. To increase the power and speed of CMA, we have developed a new array with significantly increased content and highly accelerated workflow.  The CytoScan HD Accel microarray has high-density genome-wide coverage, including increased coverage across >5070 relevant genes.  The novel Reference Model built from six unique pre and postnatal tissue types produces sensitive CNV detection with up to 25% maternal cell contamination, and trisomy detection with up to 30% contamination.  The highly accelerated workflow enables processing 24 gDNAs to hybridization in just one day.

Speaker:
John Bishop, Director, Research and Development, Microarray, Thermo Fisher Scientific

Pete Macchia of Thermo Fisher Scientific will discuss the importance of PGx research in testing as well as some of the key considerations of adopting PGx into your testing menu. This includes the importance of analytical validation as well as streamlining workflows to maximize your laboratory efficiencies. Additionally, this workshop will discuss potential areas of growth for the PGx space and how you can capitalize on this for your business.  

Speakers:
Jami Elliott, CEO, Quantigen Biosciences
Pete Macchia, Field Application Specialist, Thermo Fisher Scientific


Scientific poster presentations

November 17–18, 2023

Early identification of KRAS and PIK3CA mutations using multiplex digital PCR compatible with liquid biopsy samples to support tumor progression surveillance
Friday, November 17
Poster # G002

ASXL1 p.G646Wfs*12 detection enabled and integrated into a rapid automated myeloid variant profiling solution on Ion Torrent NGS Genexus System
Saturday, November 18
Poster # G049

Rapid NGS detection of gene mutations and fusions in myeloid neoplasms
Saturday, November 18
Poster # H003

Preparation and evaluation of MS2 phage-like particles as full process quality control for molecular assay
Friday, November 17
Poster # ID043

Expanded PCR panel testing for identification of coinfecting pathogens in viral respiratory tract infections
Friday, November 17
Poster # ID008

A green fecal sample prep workflow for comprehensive gut microbiome profiling and disease detection for clinical research
Saturday, November 18
Poster # ID013

The use of Dried Blood Spots (DBS) to enable sexually transmitted infection testing
Saturday, November 18
Poster # ID003

Characterization of the enhanced enzyme for isothermal amplification - Invitrogen Lyo-ready Bst Polymerase
Saturday, November 18
Poster # ID061

Rapid and automated comprehensive genomic profiling to assess single-gene and complex biomarkers including genomic instability
Friday, November 17 
Poster # ST058

Rapid and automated genomic profiling of lung cancer solid tumor and liquid biopsy
Friday, November 17 
Poster # ST102

Comprehensive genomic profiling of early hormone receptor positive breast cancer reveals diverse genomic alteration
Friday, November 17
Poster # ST112

Automated purification for robust sample performance on Ion Torrent Genexus System for detection and research of myeloid malignancies
Friday, November 17 
Poster # TT042

Brazilian multicenter comparative study to characterize the analytical sensitivity and expert's concordance, using target-directed sequencing FFPE samples
Saturday, November 18 
Poster # TT005

Positive enrichment of circulating tumor cells (CTCs) on the KingFisher Purification System
Saturday, November 18
Poster # TT021

Early identification of KRAS and PIK3CA mutations using multiplex digital PCR compatible with liquid biopsy samples to support tumor progression surveillance
Friday, November 17
Poster # G002

ASXL1 p.G646Wfs*12 detection enabled and integrated into a rapid automated myeloid variant profiling solution on Ion Torrent NGS Genexus System
Saturday, November 18
Poster # G049

Rapid NGS detection of gene mutations and fusions in myeloid neoplasms
Saturday, November 18
Poster # H003

Preparation and evaluation of MS2 phage-like particles as full process quality control for molecular assay
Friday, November 17
Poster # ID043

Expanded PCR panel testing for identification of coinfecting pathogens in viral respiratory tract infections
Friday, November 17
Poster # ID008

A green fecal sample prep workflow for comprehensive gut microbiome profiling and disease detection for clinical research
Saturday, November 18
Poster # ID013

The use of Dried Blood Spots (DBS) to enable sexually transmitted infection testing
Saturday, November 18
Poster # ID003

Characterization of the enhanced enzyme for isothermal amplification - Invitrogen Lyo-ready Bst Polymerase
Saturday, November 18
Poster # ID061

Rapid and automated comprehensive genomic profiling to assess single-gene and complex biomarkers including genomic instability
Friday, November 17 
Poster # ST058

Rapid and automated genomic profiling of lung cancer solid tumor and liquid biopsy
Friday, November 17 
Poster # ST102

Comprehensive genomic profiling of early hormone receptor positive breast cancer reveals diverse genomic alteration
Friday, November 17
Poster # ST112

Automated purification for robust sample performance on Ion Torrent Genexus System for detection and research of myeloid malignancies
Friday, November 17 
Poster # TT042

Brazilian multicenter comparative study to characterize the analytical sensitivity and expert's concordance, using target-directed sequencing FFPE samples
Saturday, November 18 
Poster # TT005

Positive enrichment of circulating tumor cells (CTCs) on the KingFisher Purification System
Saturday, November 18
Poster # TT021


Featured research solutions

For Research Use Only. Not for use in diagnostic procedures.