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Cell Bio Virtual 2021 – On Demand
Virtual Event
Dec 01, 2021
- Dec 10, 2021
An online ASCB | EMBO meeting
Register below to watch four exciting tech talk presentations on demand.
Explore large multi-channel and time series data with Amira software and the new Xplore5D extension
This session will focus on the visualization and image process of large 3D image data using the new capabilities of the Thermo Scientific Amira Software Solution. There will be a step-by-step demonstration of the recently added functions of Amira and its new Xplore5D extension, which enables fast and easy exploration of large multi-channel and time series data. We will also highlight and demonstrate deep learning-based training and prediction modules.
Presenters
Jan Giesebrecht, Supervisor, Product Application Specialist, Thermo Fisher Scientific
Arsalan Zolfaghari, Product Application Specialist, Thermo Fisher Scientific
Bringing tomography to cell biology via the National Network of Cryo-ET Centers
Cryo-electron tomography (cryo-ET) provides sub-nm resolution snapshots of proteins within their native cellular environments and can thus contribute to a better understanding of molecular process. The preparation of vitrified single cells for electron tomography has progressed considerably and makes it possible to peer precisely into cells. In this session, we will highlight the significance of tomography for cell biology and provide an introduction to the National Network of Cyro-Electron Tomography Centers. The mission of this network is to deploy these capabilities in support of original research efforts and to train new users in cryo-tomography.
Presenters
Elizabeth R. Wright, Professor, University of Wisconsin, Madison
Alex Rigort, Product Marketing Manager, Thermo Fisher Scientific
Physiologic medium to study human cell biology
Environmental factors influence cell physiology and can also affect drug efficacy, but existing model systems used to study human cells have limitations for understanding these contributions. Dr. Cantor will discuss the initial development and use of human plasma-like medium (HPLM) has widespread effects on metabolism and gene essentiality, and further, that HPLM can be used to reveal new insights into metabolic regulation and cellular responses to drug treatment.
Presenter
Jason R. Cantor, PhD, Investigator, Morgridge Institute for Research; Assistant Professor, Department of Biochemistry, University of Wisconsin, Madison
A journey from 2D to 3D of cells and tissues using electron microscopy
Much of our fundamental understanding of cell biology can be attributed to key findings in the early days of electron microscopy (EM). As the field of cell biology has evolved, so too have the electron microscopy imaging needs of cell biologists. Modern electron microscope technology has made it possible to meet a broader range of imaging needs, from conventional 2D surface imaging to large, high-resolution 3D volume imaging of cells and tissues. Here we will discuss how Thermo Scientific scanning and transmission electron microscopes enable researchers to explore the architecture of the cellular world.
Presenter
Blanca Carbajal Gonzalez, Sr. Consultant, Structural Biology, Thermo Fisher Scientific
Featured speakers
Elizabeth R. Wright, Professor, University of Wisconsin, Madison
Liz received her PhD in chemistry from Emory University. She engineered elastin-mimetic materials that are used for drug delivery and tissue engineering applications. She was a postdoctoral research associate in materials science at the University of Southern California and a postdoctoral scholar with Professor Grant Jensen at Caltech where she developed cryo-ET technologies and used cryo-ET to study HIV-1 maturation. She joined Emory University as an assistant professor in 2008 and was promoted to associate professor in 2016. She moved to the University of Wisconsin, Madison, as a full professor in 2018. Her research program focuses on the development and use of cryo-EM and correlative light and electron microscopy imaging technologies to determine the native-state structures of several bacterial species, bacteriophages, HIV-1, respiratory syncytial virus (RSV), measles virus (MeV), and other host-pathogen systems.
Jason R. Cantor, PhD, Investigator, Morgridge Institute for Research; Assistant Professor, Department of Biochemistry, University of Wisconsin, Madison
Jason earned his BS in chemical engineering magna cum laude from Cornell University in 2004, and in 2010 completed his PhD in chemical engineering from the University of Texas at Austin. Under the guidance of George Georgiou, Jason’s doctoral research focused on the development of new strategies to engineer therapeutic enzymes with reduced immunogenicity for cancer therapy, and was supported, in part, through a graduate fellowship awarded by the U.S. Department of Homeland Security. Jason carried out his postdoctoral research in the laboratory of David M. Sabatini at the Whitehead Institute for Biomedical Research. There, he focused on designing new tools to better understand how environmental factors influence the metabolic regulation of cancer cells. His postdoctoral research was funded, in part, through fellowships awarded by both the American Cancer Society and the Koch Institute for Integrative Cancer Research at MIT. He was also recognized with a Margaret and Herman Sokol Postdoctoral Award from the Whitehead Institute. In August 2018, Jason became a metabolism investigator at the Morgridge Institute for Research and an assistant professor in the Departments of Biochemistry and Biomedical Engineering at the University of Wisconsin, Madison.