Tradeshow
Jun 01, 2019 - Jun 06, 2019

Atlanta, GA

ASMS 2019 - Atlanta, GA
The New Pace of Innovation: Intelligence-driven Mass Spectrometry

The New Pace of Innovation: Intelligence-driven Mass Spectrometry

At ASMS 2019 in Atlanta, we introduced exciting new products, presented interesting new science, and continued to set a new pace of innovation with intelligence-driven mass spectrometry solutions that enable you to drive research discoveries and perform routine tests in extraordinary ways.

MP 145 Direct Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Ground, Surface and Waste Water by LC-MS/MS
MP 181 EU Compliant Routine Quantitative Dioxin, Dioxin-Like PCB and Marker PCB Analysis by GC-MS/MS Using an Advanced Electron Ionisation Source
MP 190 Analysis of Patulin in Fruit Juices and Extracts Using Liquid Chromatography Triple Quadrupole Mass Spectrometry
MP 733 Applications of Mass Spectrometry Targeted Assays for Quantitative Analysis of Cancer Signaling Proteins
MP 328 Developments in Orbitrap Mass Spectrometry on a Modified Tribrid Mass Spectrometer
MP 414 Optimizing the Isolation Width in Orbitrap Instruments to Maximize the Number of Label-Free Quantified Peptides and Protein
MP 434 Implementing a Generic Scripting Node to a Standard Proteomics Workflow Processing Software
MP 484 Design and Performance Improvement of an Ion Cooling Cell for a Quadrupole Mass Spectrometer
MP 491 Recent Development in Improving the Precision of Quantitative Analysis for Linear Ion Trap(LIT) and LIT-Orbitrap Tandem Mass Spectrometry
MP 492 Application of a Triple Quadrupole MS with Acquisition Speed Improvements for Pesticide Analysis
MP 564 Detecting Low Abundant Endogenous Cardiac Steroids from Biological Fluids Using Structure-Based MSn Approach On an Orbitrap Tribrid MS
MP 567 Novel Psychoactive Substances Detection Using a Novel Multi-Aspect Workflow Solutions
MP 570 A Complete Workflow for Improved Untargeted Metabolome Annotation and Identification Using Ultra High-Resolution Accurate Mass and LC-MSn Orbitrap-Based Mass Spectrometry
MP 601 Large Scale EasyPep MS Sample Preparation for Phosphopeptide Enrichment Workflows
MP 625 Utilization of Substructure Identification through MSn Analysis for Unknown Structure Determination Assisted with in silico Fragmentation Prediction
MP 683 Identifying Quantitative Protein Changes in the Iris of Glaucoma Patients Using Label Free Proteomics
MP 733 Applications of Mass Spectrometry Targeted Assays for Quantitative Analysis of Cancer Signaling Proteins
MP 734 A Modified Orbitrap Tribrid Mass Spectrometer with Real-Time Search and Advanced Spectral Processing Enhances Multiplexed Proteome Coverage and Quantification Accuracy
MP 735 Improved Identification, Quantification Accuracy, and Workflow Efficiency Using a Modified Quadrupole Orbitrap Mass Spectrometer and Tandem Mass Tags (TMT) Approach
TP 002 Analysis of Therapeutic Monoclonal Antibodies Using Volatile pH Gradient Cation Exchange Chromatography Directly Coupled to Native Mass Spectrometry
TP 014 Structural Characterizations of Intact Monoclonal Antibodies by Native MS
TP 018 Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer
TP 059 Scalable and Automated Plasma Workflow Based on the Thermo Scientific Q Exactive HF-X MS Platform
TP 062 A Highly Sensitive FFPE Tissue Workflow by Coupling the Micro Pillar Array Column (μPAC) with High Resolution Mass Spectrometry
TP 107 Analysis of Drugs in Whole Blood by PaperSpray-FAIMS-MS/MS
TP 200 Trace Determination of Octyl & Nonyl-phenols and Ethoxylates and Bisphenol A Using On-Line SPE and Q Exactive Focus Orbitrap LC-MS/MS
TP 215 Determination of Polar Pesticides in Grapes Using a Compact Ion Chromatography System Coupled with Tandem Mass Spectrometry
TP 235 Pesticide Residue Analyses of QuEChERS Extracts of Different Food Matrices Using an Online Robotic SPE Clean-up Procedure Coupled to LC-MS/MS
TP 237 A Multiresidue Method for Quantitation and Screening of Pesticide Residues in Baby Food Using LC-MS/MS
TP 238 A Multiresidue Method for Pesticide Analysis Using a Tribrid Orbitrap Mass Spectrometer and Automatic Background Exclusion
TP 310 Coupling Comprehensive Two-Dimensional Gas Chromatography with an Orbitrap MS for Enhanced Separation and Identification
TP 311 Qualitative and Quantitative Analysis of Electronic Cigarette Liquids using Gas Chromatography – Orbitrap Mass Spectrometry
TP 525 Affecting FAIMS Separation with Trace Levels of Gas Modifiers
TP 526 Developing the Research to Routine Workflows with FAIMS: Automating Large-Scale SRM Method Creation for Routine Plasma Proteomics Screening
TP 527 FAIMS Pro interface Coupled to Triple Quadrupole Mass Spectrometry for Quantification of Peptides in Complex Matrices
TP 528 Lifting the Albumin Curtain to Increase Plasma Proteome Profiling: Incorporating Differential Ion Mobility for Increased Protein Coverage
TP 533 High-Throughput Metabolite Profiling of Cell Media for Improved Antibody Production Utilizing a Dual Separation/Mass Spectrometry System with Intelligent MSn Acquisition
TP 573 Quantitative, Comprehensive Multi-Pathway Signaling Analysis Using an Optimized Phosphopeptide Enrichment Method Combined with an Internal Standard Triggered Targeted MS Assay
TP 579 Real-Time, High Density Monitoring of pTyr Signaling Targets in Human Tumors Using Heavy Peptide Triggered Targeted Quantitation
TP 591 A High Resolution Accurate Mass Multi-Attribute Method for Critical Quality Attribute Monitoring and New Peak Detection
TP 661 The Strange Case of “Picket Fence” Peaks: A Study in the Complexity of MS/MS Spectra of Protein Ions
TP 683 Comprehensive Evaluation of Shotgun Proteomics Using Thermo Scientific Orbitrap Fusion Lumos Mass Spectrometer with FAIMS Pro Interface
TP 725 High-Throughput Top-Down FAIMS Data Analysis with ProSight PD Nodes in the Thermo Scientific Proteome Discoverer Software
TP 756 Building Local Proprietary Libraries with Automated MSn Spectral Tree Curation and New Library Searching Tools
TP 018 Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer
TP 533 High-throughput Metabolite Profiling of Cell Media for Improved Antibody Production Utilizing a Dual Separation/Mass Spectrometry System with Intelligent MSn Acquisition
TP 526 Developing the Research to Routine Workflows with FAIMS: Automating Large-scale SRM Method Creation for Routine HeLa Peptide Screening
TP 661 The Strange Case of “Picket Fence” Peaks : A study in the Complexity of MS/MS Spectra of Protein Ions
WP 070 Global Plasma Proteome Quantification Using Internal Standard Triggered Targeted Analyses
WP 144 Evaluation of FAIMS Technology for Mass Spec Analysis of Chemical Cross-Linked Peptides
WP 182 Introduction of a Novel Labelling Strategy to Facilitate LC-MS Analysis of Released N-Glycans
WP 209 A High Throughput and High Resolution LC-MS/MS Method to Measure IGF1 in Serum for Clinical Research
WP 218 Reliable Quantification of 52 Amino Acids in Human Plasma by LC-MS/MS
WP 282 Screening and Quantitation of Drugs Illegally Added to Health Foods by UHPLC-Hybrid Quadrupole-Orbitrap Mass Spectrometry
WP 284 Multi-class Veterinary Drug Screening and Quantitation with a Comprehensive Workflow
WP 289 Sensitive Determination of Polar Anionic Pesticides in Wheat Flour by Stable Isotope Dilution Ion Chromatography−Tandem Mass Spectrometry
WP 290 Fragmentation Pathways of Synthetic Drugs Added in Health Food Based on Higher Energy Collisional Dissociation in High-Resolution Quadrupole-Orbitrap Mass Spectrometry
WP 303 Rapid Measurement of Agrochemicals by PaperSpray Mass Spectrometry
WP 312 Combining Chromatographic Deconvolution, Spectral Library Search, and Principle Component Analysis to Detect and Identify Important Flavour and Fragrance Compounds with High Resolution GC/MS
WP 324 Detection and Quantification of Fragrance Allergens in Complex Matrices Using GC-Orbitrap MS Technology
WP 436 Performance Evaluation of a Modified Quadrupole Orbitrap Mass Spectrometer
WP 438 Reliable and Deep Proteome Coverage by Gas-Phase Fractionation of Peptides with a FAIMS Pro Interface on a Modified Quadrupole Orbitraple Orbitrap
WP 452 Modifying the Ion Optics and Scan Sequences on a Tribrid MS to Improve Sensitivity, Duty Cycle, and Overall Instrument Ease-of-Use
WP 503 Ultra-fast Capillary-Flow LC-MS Profiling of Complex Biological Matrices: Applicable to Large Sample Cohorts
WP 527 Automating the Analysis of Estrogens in Plasma using a Multi-Purpose Auto-Sampler Coupled to Liquid Chromatography Triple Quadrupole Mass Spectrometry
WP 645 Evaluation of an Automated, Acidic pH Protein Digestion for Reduced Levels of Artificial Deamidation in Biotherapeutic Peptide Mapping Studies
WP 693 Retention Time Correction Method Utilizing Unspecified Peaks in MS Scans
WP 700 Towards Turnkey Targeted Proteomics Solutions using Internal Standard Triggered Acquisitions on Modified Orbitrap Mass Spectrometers
WP 742 Proteomic Analysis of Plasma – Sample Preparation and Multiplexing Workflows for Relative Quantitation
WP 771 Optimization of Collision Cell Potentials for Analysis of Opiates and their Glucuronyl Metabolites in a Triple Quadrupole Mass Spectrometer
WP 218 Reliable Quantitation on 52 L-Amino Acids in Human Plasma for Clinical Research by LC-MS/MS
ThP 024 Analysis of Immunosuppressant Drugs Directly from Whole Blood using PaperSpray Technology
ThP 052 Key Factors Influencing Nano-Electrospray Ionization Efficiency of Tryptic Peptides from Fused Silica Emitters During Reversed-Phase Liquid Chromatography Separations
ThP 095 Low ppm Detection of Host Cell Proteins (HCPs) in Biotherapeutics with Optimised Orbitrap-Based UHPLC HRAM MS
ThP 099 Rapid Proteome Analysis with Data-Independent Acquisition and Super-Resolution Orbitrap Mass Spectrometry
ThP 136 A Sensitive and Selective LC-UV-MS Method for Determining Genotoxic Impurities in Drugs
ThP 170 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for the Analysis of the Spatial Distribution of Trace Elements in Biological Systems
ThP 208 Improved Profiling of Sialylated N-Linked Glycans by Ion Chromatography-Orbitrap Mass Spectrometry
ThP 213 Confident and Efficient Characterization of Recombinant Human Follicle Stimulating Hormone with the Thermo Scientific Q Exactive HF-X BioPharma Platform
ThP 391 Improved Lipid Annotation Depth Using Automatically Generated Inclusion and Exclusion Lists on an Orbitrap-Based Mass Spectrometer
ThP 500 Intelligent Acquisition for Comprehensive Metabolome Coverage in Plants, Mammals, and Bacteria
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 500 Intelligent Acquisition for Comprehensive Metabolome Coverage in Plants, Mammals, and Bacteria
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 052 Key Factors Influencing Nano Electrospray Ionization Efficiency of Tryptic Peptides from Fused Silica Emitters During Reversed Phase Liquid Chromatography Separations

Our popular Users' Meeting featured presentations from experts that demonstrated how our mass spectrometry solutions – from HRAM Orbitrap systems to sensitive triple quads to powerful software – can help you keep up with the new pace of innovation that accelerates research discoveries and perform routine tests in extraordinary ways.

8:00 – 9:30 a.m.
Marquis Ballroom A/B

Welcome and Introduction
Ken Miller, Vice President, Omics Vertical Marketing, Thermo Fisher Scientific

Informing Drug Discovery and Membrane Protein Biophysics
Carol Robinson, Professor, University of Oxford

Developments in high-resolution Orbitrap mass spectrometry are enabling the study of membrane protein complexes from a variety of sources, including natural membrane environments. Given that membrane proteins represent critical drug targets, finding new ways to assess the binding and impact of drugs in these complexes is a major goal in the pharmaceutical industry. In my lecture, I will show recent results for G-protein coupled receptors and ion channels that link lipid and drug binding in these important targets.

Exploring New Heights on the Orbitrap Journey
Alexander Makarov, Director of Global Research, Life Science Mass Spectrometry, Thermo Fisher Scientific

Presentation of Orbitrap proof-of-principle at the ASMS Conference exactly 20 years ago marked the start of a long journey from a little scientific curiosity to the leading technique for high resolution accurate mass analysis. Over this time, the performance envelope of technology has been relentlessly extended and magnified by coupling with additional capabilities such as quantitative analysis, new ionization, fragmentation and signal processing methods, parallelization of detection and ion processing, and intricate coordination with different ion-optical devices. As the result, thousands of instruments of three major families are used worldwide around the clock not only for high-end -omic applications but also for screening, trace and targeted analysis by LC-MS and GC-MS.

This presentation will reveal new important steps on this journey and what the next twenty years will bring in terms of making the world healthier, cleaner, and safer.

9:30 a.m. - 12:15 p.m.
Marquis Ballroom A/B

Accelerating Insights in Structure and Function in Omics Research

Confidently determining molecular structure is increasingly becoming routinely possible on a large scale using advanced Thermo Scientific™ Orbitrap™ mass spectrometry tools. Integrated solutions for structural analysis available now shift the research focus in many laboratories from sequence to structure accelerating insights into functional aspects of biological systems. Join us in this session where our expert speakers share the newest developments in HRAM Orbitrap MS technology with applications in integrated structural protein analysis, multiplexed proteome profiling, and structural elucidation for metabolomics.

  • Performance Evaluation of a Modified Benchtop Orbitrap Instrument Equipped with a Thermo Scientific FAIMS Pro Interface for Proteomics
    Jesper Olsen, Professor, University of Copenhagen
  • Multi-omics Investigation of Colorectal Cancer Metabolism Reveals KRAS-driven Metabolic Alterations
    Peter F. Doubleday, NSF Graduate Research Fellow, Northwestern University
  • Ultrahigh Performance for Resolving Proteoforms in Targeted and Discovery Modes
    Neil Kelleher, Director, Northwestern University
  • High-throughput Identification of Novel Tomato Flavonoids by a Structure-based Profiling and Annotation Workflow
    Sheng Zhang, Director, Cornell University
  • Instant Answer: All the Data in Half the Time Using a Real-time Database Search for Isobaric Labeling Studies
    Steven Gygi, Professor, Harvard University

9:30 a.m. - 12:15 p.m.
Marquis Ballroom C

From Research to Routine: Innovations in Pharma and BioPharma

The range of Thermo Scientific advanced mass spectrometry-based workflow solutions can be applied to reveal comprehensive structural insights in pharmaceutical and biopharmaceutical discovery and development. The introduction of high resolution accurate mass MS into the routine manufacturing and quality control/lot release environment for precise drug attribute and quality monitoring is rapidly becoming a reality. To understand more about our solutions and latest technologies, join this session and hear expert speakers share their experiences in the application of mass spectrometry from research – including advanced fragmentation techniques, non-traditional separations coupled to mass spectrometry, and next-generation structural elucidation tools – to accurate and precise routine product attribute characterization and quantitation with automated sample preparation and data processing regimes.

  • Characterizing Biopharmaceuticals and Bioprocesses Using Native Thermo Scientific Orbitrap LC-MS
    Jonathan Bones, Principal Investigator, National Institute for Bioprocessing Research and Training
  • Unraveling Complex Biotherapeutics: Native Tandem Mass Spectrometry on Heterogeneous Glycoproteins and Protein Complexes
    Wendy Sandoval, Principal Scientific Manager in Research, Genentech
  • New Enzymatic Workflows for Analysis of O-Glycosylated Biopharmaceuticals
    Andreas Naegeli, Senior Scientist, Genovis
  • A New Strategy Optimized for Metabolite Profiling on Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer Platform
    Qian Ruan, Senior Research Investigator, Bristol Myers-Squibb
  • Understanding Biotherapeutic Product Quality Attributes through a Multi-Attribute Method (MAM) Lab-of-the-Future
    Andrew Dawdy, Principal Scientist, Pfizer

9:30 a.m. - 12:15 p.m.
Rooms M303-M304

Novel Mass Spectrometry Solutions in Food and Environmental Testing

Mass spectrometry and chromatographic techniques in the food and environmental industries continue to evolve, including solutions for adjacent markets. Join us during this session to hear our collaborators and guest speakers discuss how they have used Thermo Scientific LC-MS and GC-MS triple quadrupole MS and Thermo Scientific Orbitrap and Tribrid MS technologies to solve challenges in environmental testing, pesticides analysis, and food authenticity.

  • LC-MS and GC-MS Solutions for Cannabis Testing Standardization
    Garnet McRae, Technical Officer, National Research Council of Canada
  • Analysis of Silicone Wristbands Using GC Orbitrap High Resolution Mass Spectrometry to Characterize Personal Exposures
    Nicholas J. Herkert, Postdoctoral Associate, Duke University
  • Gelatin Adulteration: A Comprehensive Targeted Proteomic and Mass Spectrometry Strategy For Food Authenticity
    Francis Beaudry, Professor, University of Montréal
  • On-site Environmental Monitoring of Swiss Aquatic Systems Using a Transportable Thermo Scientific Q Exactive HF Mass Spectrometer
    Heinz Singer, Senior Scientist & Group Leader, Eawag
  • See the Pesticides You`ve Been Missing with a Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer and AcquireX
    Anastasia Kalli, Senior Product Applications Specialist, Thermo Fisher Scientific

9:30 a.m. - 12:15 p.m.
Marquis Ballroom D

Ensure a Healthier Tomorrow

The application of mass spectrometry and associated novel technologies to better understand complex diseases and new disease types continues to grow at an exponential rate. The need to detect, identify, confirm and quantify critical markers is higher than ever before. Hence, an optimal combination of advanced modern analytical technologies with innovative minds brings out effective and impactful solutions that address the most critical challenges faced by the scientists in clinical research. LC-MS on one hand offers a unique ability to leverage high resolution accurate mass for identification, characterization, confirmation, and untargeted quantitation of critical analytes regardless of their size and type. On the other hand, triple quadrupole MS enables development of sensitive, robust, reliable, and reproducible quantitation of the well characterized analytes. This session will focus on highlighting unique and novel use of LC-MS and LC-MS-based technologies for characterization to quantitation of different classes of analytes (from proteins to small molecules) in a variety of matrices (from tissues to plasma) used for clinical research.

  • VeriSpray: A High-throughput PaperSpray MS/MS System Applied to Clinical Research and Drug Screening
    Nicholas Manicke, Assistant Professor, Indiana University – Purdue University Indianapolis (IUPUI)
  • Development and Clinical Translation of the MassSpec Pen for Intraoperative Tissue Analysis
    Livia S. Eberlin, Assistant Professor and Principal Investigator, University of Texas Austin
  • Rapid Diagnostic Platform for Microbiology – Technology for Targeted Microbiome, Clinical Microbiology, and Precision Microbiology
    Ian Lewis, Assistant Professor, University of Calgary
  • Development of Biomarker Panels for Spontaneous Pre-term Birth Preeclampsia using a Novel, Exosomal Proteomics Platform
    Kevin Rosenblatt, Chief Scientific and Chief Medical Officer and Adjunct Associate Professor, NxPrenatal, Inc. and University of Texas McGovern Medical School
  • Practical Translation: Integration of Remote Biomarker Assessment in a Hospital System
    Jenny van Eyk, Director, Cedars Sinai

Our experts showed how to do more with our powerful mass spectrometry software tools. Attendees sharpened their skills, learned useful tips, and got a preview of new and exciting features in the latest versions.

Smarter. Faster. Simpler. Becoming an Orbitrap Power User.

Excited by the power and potential of your Thermo Scientific Orbitrap-based mass spectrometer? From small molecules to large, receive training on system calibration and maintenance, built-in workflows and advanced, custom method execution to allow you to increase your impact within the laboratory. Join us for first-hand demonstrations of the new features in the Tune, Method Editor, and Thermo Scientific Xcalibur applications; including AcquireX intelligent acquisition.

Agenda*

  • Registration & Continental Breakfast
  • Welcome and Introduction
  • Calibration and Preventive Maintenance
  • Instrument Control Software Overview and Software Updates
  • Xcalibur and AcquireX Updates
  • Data Acquisition Strategies for Peptide Characterization and Quantitation
  • Internal Standard-triggered Data Acquisition for Targeted Peptide Quantitation
  • RawFileReader & Xcalibur XDK Updates
  • Instrument API and XML Method Modification Interface
  • Advanced Data Acquisition with MaxQuant.Live- Florian Meier, Postdoctoral Researcher, Max Planck Institute of Biochemistry
  • TomahaqCompanion for Automated Creation of Targeted Methods that Utilize Internal Standard Peptides- Christopher Rose, Scientist, Genentech
  • Smart TMT with iAPI- Qing Yu, Postdoctoral Research Fellow, Harvard Medical School
  • Small Molecule Structure Characterization
  • Structure-based Unknown Metabolite Annotation Powered by MSn and Cutting-edge Software Tools
  • An Almanac Overview for Connected Instruments
* Topics subject to change
Powerful. Flexible. Innovative. Getting the Most from Thermo Scientific Compound Discoverer Software.

Want to get more out of Compound Discoverer software? Whether you are involved in metabolomics, environmental research, forensics, or metabolism studies, this software is the solution for small molecules. A comprehensive and flexible set of tools help you go from sample to structure, no matter what the challenge is. Join us for a discussion of the major features of Compound Discoverer software and learn about the features of the new version 3.1.

Agenda*

  • Registration and Continental Breakfast
  • Welcome and Introduction to Compound Discoverer Software
  • What’s New in Compound Discoverer 3.1 Software
  • Third-party Nodes in Compound Discoverer Software
  • Updates on mzCloud
  • Tips & Tricks, Discussion
  • Lunch
* Topics subject to change
The Present and the Future

Join the Thermo Scientific Proteome Discoverer software team to learn about topics ranging from peptide identification and quantification, to crosslinks, proteoforms, and PTM analysis. We will review in detail the recent Proteome Discoverer 2.3 software release and give a preview of the soon-to-be-released Proteome Discoverer 2.4 software. We are also pleased to host Siegfried Gessulat from TUM, who will present an overview of the PROSIT method for deep learning-based prediction of mass spectra.

Agenda*

  • Lunch and Registration
  • Welcome & Introduction to Proteome Discoverer Software: Overview of What's New in Version 2.3
  • XlinkX and TMT
  • The Latest Proteome Discoverer 2.3 Features (Continued)
  • PROSIT for Deep Learning-based Prediction of Mass Spectra
  • ProSight PD 2.0 and 3.0
  • Proteome Discoverer 2.3 (Continued) and Proteome Discoverer 2.4 Preview
  • Q&A
* Topics subject to change

Attendees our Breakfast Workshops learned from fellow scientists and Thermo Fisher Scientific experts how intelligence-driven mass spectrometry solutions enable them to drive research discoveries and perform routine tests in extraordinary ways.

Monday

Monday, June 3 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

A next-generation benchtop quadrupole-Orbitrap hybrid mass spectrometer significantly advances performance and achievable results in many important application areas, including protein profiling with FAIMS next generation ion mobility technology, quantitative protein analysis, and detailed protein characterization for translational research. Leveraging new design features, the system takes advantage of a multitude of novel ion-optical and instrument intelligence-driven design solutions that update and extend capabilities to deliver the performance, robustness, reliability, and data certainty beyond that of current high resolution mass spectrometers.

  • Introduction to Next-generation Benchtop Quadrupole-Orbitrap Hybrid Mass Spectrometer – New Platform, New Technology, Novel Capabilities
    Alexander Harder, Senior Platform Manager, Thermo Fisher Scientific
  • Intelligent Acquisition Strategies to Streamline Quantitative Proteomics
    Aaron M. Robitaille, Senior Product Applications Specialist, Thermo Fisher Scientific

Monday, June 3 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Comprehensive LC-MS-based characterization of therapeutic proteins requires detailed molecular knowledge, including primary structure, modifications, and higher order structural variation. To address the versatility and throughput requirements of comprehensive characterization, the use of a single Thermo Scientific OrbitrapMS-based analytical platform for multiple advanced characterization workflows will be described. The Multi-Attribute Method (MAM) aims to simplify and automate characterization and QC efforts. MAM is a compliance-ready method capable of monitoring multiple biopharmaceutical attributes and confirming product purity. In the pursuit of a fully automated MAM, data will be presented demonstrating the robustness and reproducibility of an automated sample preparation approach.

  • Digging Deeper in Every Direction: Developing a Next-generation Platform for High-throughput Multi-facet Protein Characterization
    Aaron Bailey, Mass Spectrometry Services Product Manager, BGI Genomics
  • The Journey to Fully Automated MAM
    Richard Rogers, Principal Scientist, Just Biotherapeutics

Tuesday

Tuesday, June 4 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

Quantitative proteomics strategies using Tandem Mass Tags (TMT) enable precise measurement of protein abundance from multiple samples into a single high-resolution LC-MS analysis. Increasingly, various biological experiments demand higher multiplexing and sample throughput with accurate quantitation. In this workshop, our expert speakers will lay out strategies that combine next generation technologies in multiplexing chemistry, hardware, and software to achieve increased quantitative performance and throughput efficiency on Thermo Scientific Orbitrap Mass Spectrometers. This includes Advanced MS2 and Advanced SPS-MS3 approaches utilizing next-generation isobaric tags, Real Time Search (RTS), and gas-phase fractionation with the Thermo Scientific FAIMS Pro interface. Together, these advances allow for intelligent acquisition methods that improve quantitation accuracy, precision, and proteome depth.

  • Going Beyond 11: Increasing Quantitative Proteomic Sample Multiplexing Using Next-generation Mass Tags and Orbitrap Mass Spectrometers
    Ryan Bomgarden, Senior Staff Scientist, Team Leader, Thermo Fisher Scientific
  • Increasing the Breadth and Depth of Multiplexed Quantitation Using Advanced Instrumentation and Methods
    Devin Karl Schweppe and Qing Yu, Postdoctoral Fellows, Harvard Medical School

Tuesday, June 4 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Untargeted metabolomics provides comprehensive coverage of the metabolome. However, challenges remain due to the chemical diversity of metabolites and confident compound annotation of biologically relevant compounds. The development of novel MS workflows with intelligent acquisition strategies and powerful data processing software increases annotation throughput. In this workshop learn how Thermo Scientific Orbitrap MS and new dual/tandem HPLC technologies reinvented the untargeted metabolomics workflow.

  • Maximizing Throughput and Metabolome Coverage with Dual Separation LC-MS
    Ioanna Ntai, Strategic Marketing Specialist, Thermo Fisher Scientific
  • High-resolution Mass Spectrometry-based Untargeted Metabolomics Method for the Identification of Glucuronide Biotransformation Products in Environmentally Exposed Fish
    Jonathan Mosley, Research Biologist, U.S. Environmental Protection Agency
  • Improving Metabolome Coverage with the Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer
    Michaela Schwaiger-Haber, Research Scientist, Washington University in St. Louis

Wednesday

Wednesday, June 5 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

Accurate monitoring of cell signaling pathway proteins has proven challenging due to the low cellular abundance of these targets and lack of standardized targeted proteomic methodologies and reagents. In this workshop, our expert speakers will share the latest advances and newest technologies in targeted peptide quantitation and pathway analysis, including our panel of Thermo Scientific SureQuant multiplex immunoprecipitation targeted mass spectrometry kits. They will also introduce the novel SureQuant internal standard triggered parallel reaction monitoring (IS-PRM) methodology for more reproducible and sensitive quantitation on Thermo Scientific Orbitrap mass spectrometers.

  • Introducing Thermo Scientific SureQuant IS-PRM, a Targeted Proteomics Methodology for Maximum Quantitative Performance - Aaron Gajadhar, Proteomics Strategic Marketing, Thermo Fisher Scientific
  • High-density Monitoring of pTyr Signaling Targets in Human Tumors Using Heavy Peptide Triggered Targeted Quantitation -Forest White, Professor, Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology

Wednesday, June 5 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Structural elucidation, including metabolite identification, pharmaceutical forced degradation studies, and impurity identification are a critical part of any new drug development. In this study, degradation profiling of structurally diverse drugs was performed. Utilizing high resolution MS/MS and multistage MSn data acquisition, as well as unique workflows afforded by the acquisition system, such as automated background subtraction and isotopic filtering to trigger fragmentation, demonstrated that both MS/MS and MSn triggering rates were substantially increased. Processing increased amounts of data is the bottleneck for many small molecule applications, but with novel software tools and algorithms, confident and efficient component identification and structural elucidation were achieved with ease.

  • Tackling the Unknown Structural Elucidation Bottleneck with Mass Spectral Libraries
    Charles Cheng, Associate Director, Analytical Development Blueprint Medicines
  • Solution for Small Molecule Unknowns
    Tim Stratton, Senior Manager Software and Library Management, Thermo Fisher Scientific

Thursday

Thursday, June 6 | 7 – 8 a.m.
Georgia World Congress Center
Room A302

To understand protein functioning in the cellular environment, it is essential that researchers determine protein complex assembly and structure beyond that of individual proteins. Solving the structure of large dynamic complexes often requires integrating several complementary mass spectrometry techniques—an approach known as integrative structural biology. Thermo Fisher Scientific leads the way in accelerating protein structure-function studies with its Integrative Structural Biology solutions. In this workshop, our expert speakers will share new approaches for structural proteomics workflows.

  • New Tools for Native Mass Spectrometry: Online Separation Techniques and Complex-down Surface-induced Dissociation
    Zac VanAernum, Graduate Student, Vicki Wysocki Lab, Ohio State University
  • Applying Proteomics Principles to the Analysis of Large Complexes by HDX-MS
    Malvina Papanastasiou, Research Scientist, Broad Institute of MIT & Harvard
MP 145 Direct Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Ground, Surface and Waste Water by LC-MS/MS
MP 181 EU Compliant Routine Quantitative Dioxin, Dioxin-Like PCB and Marker PCB Analysis by GC-MS/MS Using an Advanced Electron Ionisation Source
MP 190 Analysis of Patulin in Fruit Juices and Extracts Using Liquid Chromatography Triple Quadrupole Mass Spectrometry
MP 733 Applications of Mass Spectrometry Targeted Assays for Quantitative Analysis of Cancer Signaling Proteins
MP 328 Developments in Orbitrap Mass Spectrometry on a Modified Tribrid Mass Spectrometer
MP 414 Optimizing the Isolation Width in Orbitrap Instruments to Maximize the Number of Label-Free Quantified Peptides and Protein
MP 434 Implementing a Generic Scripting Node to a Standard Proteomics Workflow Processing Software
MP 484 Design and Performance Improvement of an Ion Cooling Cell for a Quadrupole Mass Spectrometer
MP 491 Recent Development in Improving the Precision of Quantitative Analysis for Linear Ion Trap(LIT) and LIT-Orbitrap Tandem Mass Spectrometry
MP 492 Application of a Triple Quadrupole MS with Acquisition Speed Improvements for Pesticide Analysis
MP 564 Detecting Low Abundant Endogenous Cardiac Steroids from Biological Fluids Using Structure-Based MSn Approach On an Orbitrap Tribrid MS
MP 567 Novel Psychoactive Substances Detection Using a Novel Multi-Aspect Workflow Solutions
MP 570 A Complete Workflow for Improved Untargeted Metabolome Annotation and Identification Using Ultra High-Resolution Accurate Mass and LC-MSn Orbitrap-Based Mass Spectrometry
MP 601 Large Scale EasyPep MS Sample Preparation for Phosphopeptide Enrichment Workflows
MP 625 Utilization of Substructure Identification through MSn Analysis for Unknown Structure Determination Assisted with in silico Fragmentation Prediction
MP 683 Identifying Quantitative Protein Changes in the Iris of Glaucoma Patients Using Label Free Proteomics
MP 733 Applications of Mass Spectrometry Targeted Assays for Quantitative Analysis of Cancer Signaling Proteins
MP 734 A Modified Orbitrap Tribrid Mass Spectrometer with Real-Time Search and Advanced Spectral Processing Enhances Multiplexed Proteome Coverage and Quantification Accuracy
MP 735 Improved Identification, Quantification Accuracy, and Workflow Efficiency Using a Modified Quadrupole Orbitrap Mass Spectrometer and Tandem Mass Tags (TMT) Approach
TP 002 Analysis of Therapeutic Monoclonal Antibodies Using Volatile pH Gradient Cation Exchange Chromatography Directly Coupled to Native Mass Spectrometry
TP 014 Structural Characterizations of Intact Monoclonal Antibodies by Native MS
TP 018 Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer
TP 059 Scalable and Automated Plasma Workflow Based on the Thermo Scientific Q Exactive HF-X MS Platform
TP 062 A Highly Sensitive FFPE Tissue Workflow by Coupling the Micro Pillar Array Column (μPAC) with High Resolution Mass Spectrometry
TP 107 Analysis of Drugs in Whole Blood by PaperSpray-FAIMS-MS/MS
TP 200 Trace Determination of Octyl & Nonyl-phenols and Ethoxylates and Bisphenol A Using On-Line SPE and Q Exactive Focus Orbitrap LC-MS/MS
TP 215 Determination of Polar Pesticides in Grapes Using a Compact Ion Chromatography System Coupled with Tandem Mass Spectrometry
TP 235 Pesticide Residue Analyses of QuEChERS Extracts of Different Food Matrices Using an Online Robotic SPE Clean-up Procedure Coupled to LC-MS/MS
TP 237 A Multiresidue Method for Quantitation and Screening of Pesticide Residues in Baby Food Using LC-MS/MS
TP 238 A Multiresidue Method for Pesticide Analysis Using a Tribrid Orbitrap Mass Spectrometer and Automatic Background Exclusion
TP 310 Coupling Comprehensive Two-Dimensional Gas Chromatography with an Orbitrap MS for Enhanced Separation and Identification
TP 311 Qualitative and Quantitative Analysis of Electronic Cigarette Liquids using Gas Chromatography – Orbitrap Mass Spectrometry
TP 525 Affecting FAIMS Separation with Trace Levels of Gas Modifiers
TP 526 Developing the Research to Routine Workflows with FAIMS: Automating Large-Scale SRM Method Creation for Routine Plasma Proteomics Screening
TP 527 FAIMS Pro interface Coupled to Triple Quadrupole Mass Spectrometry for Quantification of Peptides in Complex Matrices
TP 528 Lifting the Albumin Curtain to Increase Plasma Proteome Profiling: Incorporating Differential Ion Mobility for Increased Protein Coverage
TP 533 High-Throughput Metabolite Profiling of Cell Media for Improved Antibody Production Utilizing a Dual Separation/Mass Spectrometry System with Intelligent MSn Acquisition
TP 573 Quantitative, Comprehensive Multi-Pathway Signaling Analysis Using an Optimized Phosphopeptide Enrichment Method Combined with an Internal Standard Triggered Targeted MS Assay
TP 579 Real-Time, High Density Monitoring of pTyr Signaling Targets in Human Tumors Using Heavy Peptide Triggered Targeted Quantitation
TP 591 A High Resolution Accurate Mass Multi-Attribute Method for Critical Quality Attribute Monitoring and New Peak Detection
TP 661 The Strange Case of “Picket Fence” Peaks: A Study in the Complexity of MS/MS Spectra of Protein Ions
TP 683 Comprehensive Evaluation of Shotgun Proteomics Using Thermo Scientific Orbitrap Fusion Lumos Mass Spectrometer with FAIMS Pro Interface
TP 725 High-Throughput Top-Down FAIMS Data Analysis with ProSight PD Nodes in the Thermo Scientific Proteome Discoverer Software
TP 756 Building Local Proprietary Libraries with Automated MSn Spectral Tree Curation and New Library Searching Tools
TP 018 Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer
TP 533 High-throughput Metabolite Profiling of Cell Media for Improved Antibody Production Utilizing a Dual Separation/Mass Spectrometry System with Intelligent MSn Acquisition
TP 526 Developing the Research to Routine Workflows with FAIMS: Automating Large-scale SRM Method Creation for Routine HeLa Peptide Screening
TP 661 The Strange Case of “Picket Fence” Peaks : A study in the Complexity of MS/MS Spectra of Protein Ions
WP 070 Global Plasma Proteome Quantification Using Internal Standard Triggered Targeted Analyses
WP 144 Evaluation of FAIMS Technology for Mass Spec Analysis of Chemical Cross-Linked Peptides
WP 182 Introduction of a Novel Labelling Strategy to Facilitate LC-MS Analysis of Released N-Glycans
WP 209 A High Throughput and High Resolution LC-MS/MS Method to Measure IGF1 in Serum for Clinical Research
WP 218 Reliable Quantification of 52 Amino Acids in Human Plasma by LC-MS/MS
WP 282 Screening and Quantitation of Drugs Illegally Added to Health Foods by UHPLC-Hybrid Quadrupole-Orbitrap Mass Spectrometry
WP 284 Multi-class Veterinary Drug Screening and Quantitation with a Comprehensive Workflow
WP 289 Sensitive Determination of Polar Anionic Pesticides in Wheat Flour by Stable Isotope Dilution Ion Chromatography−Tandem Mass Spectrometry
WP 290 Fragmentation Pathways of Synthetic Drugs Added in Health Food Based on Higher Energy Collisional Dissociation in High-Resolution Quadrupole-Orbitrap Mass Spectrometry
WP 303 Rapid Measurement of Agrochemicals by PaperSpray Mass Spectrometry
WP 312 Combining Chromatographic Deconvolution, Spectral Library Search, and Principle Component Analysis to Detect and Identify Important Flavour and Fragrance Compounds with High Resolution GC/MS
WP 324 Detection and Quantification of Fragrance Allergens in Complex Matrices Using GC-Orbitrap MS Technology
WP 436 Performance Evaluation of a Modified Quadrupole Orbitrap Mass Spectrometer
WP 438 Reliable and Deep Proteome Coverage by Gas-Phase Fractionation of Peptides with a FAIMS Pro Interface on a Modified Quadrupole Orbitraple Orbitrap
WP 452 Modifying the Ion Optics and Scan Sequences on a Tribrid MS to Improve Sensitivity, Duty Cycle, and Overall Instrument Ease-of-Use
WP 503 Ultra-fast Capillary-Flow LC-MS Profiling of Complex Biological Matrices: Applicable to Large Sample Cohorts
WP 527 Automating the Analysis of Estrogens in Plasma using a Multi-Purpose Auto-Sampler Coupled to Liquid Chromatography Triple Quadrupole Mass Spectrometry
WP 645 Evaluation of an Automated, Acidic pH Protein Digestion for Reduced Levels of Artificial Deamidation in Biotherapeutic Peptide Mapping Studies
WP 693 Retention Time Correction Method Utilizing Unspecified Peaks in MS Scans
WP 700 Towards Turnkey Targeted Proteomics Solutions using Internal Standard Triggered Acquisitions on Modified Orbitrap Mass Spectrometers
WP 742 Proteomic Analysis of Plasma – Sample Preparation and Multiplexing Workflows for Relative Quantitation
WP 771 Optimization of Collision Cell Potentials for Analysis of Opiates and their Glucuronyl Metabolites in a Triple Quadrupole Mass Spectrometer
WP 218 Reliable Quantitation on 52 L-Amino Acids in Human Plasma for Clinical Research by LC-MS/MS
ThP 024 Analysis of Immunosuppressant Drugs Directly from Whole Blood using PaperSpray Technology
ThP 052 Key Factors Influencing Nano-Electrospray Ionization Efficiency of Tryptic Peptides from Fused Silica Emitters During Reversed-Phase Liquid Chromatography Separations
ThP 095 Low ppm Detection of Host Cell Proteins (HCPs) in Biotherapeutics with Optimised Orbitrap-Based UHPLC HRAM MS
ThP 099 Rapid Proteome Analysis with Data-Independent Acquisition and Super-Resolution Orbitrap Mass Spectrometry
ThP 136 A Sensitive and Selective LC-UV-MS Method for Determining Genotoxic Impurities in Drugs
ThP 170 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for the Analysis of the Spatial Distribution of Trace Elements in Biological Systems
ThP 208 Improved Profiling of Sialylated N-Linked Glycans by Ion Chromatography-Orbitrap Mass Spectrometry
ThP 213 Confident and Efficient Characterization of Recombinant Human Follicle Stimulating Hormone with the Thermo Scientific Q Exactive HF-X BioPharma Platform
ThP 391 Improved Lipid Annotation Depth Using Automatically Generated Inclusion and Exclusion Lists on an Orbitrap-Based Mass Spectrometer
ThP 500 Intelligent Acquisition for Comprehensive Metabolome Coverage in Plants, Mammals, and Bacteria
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 500 Intelligent Acquisition for Comprehensive Metabolome Coverage in Plants, Mammals, and Bacteria
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 664 Proteomic Analysis of Cell Surface Proteins with Improved Specificity of Enrichment
ThP 052 Key Factors Influencing Nano Electrospray Ionization Efficiency of Tryptic Peptides from Fused Silica Emitters During Reversed Phase Liquid Chromatography Separations

Our popular Users' Meeting featured presentations from experts that demonstrated how our mass spectrometry solutions – from HRAM Orbitrap systems to sensitive triple quads to powerful software – can help you keep up with the new pace of innovation that accelerates research discoveries and perform routine tests in extraordinary ways.

8:00 – 9:30 a.m.
Marquis Ballroom A/B

Welcome and Introduction
Ken Miller, Vice President, Omics Vertical Marketing, Thermo Fisher Scientific

Informing Drug Discovery and Membrane Protein Biophysics
Carol Robinson, Professor, University of Oxford

Developments in high-resolution Orbitrap mass spectrometry are enabling the study of membrane protein complexes from a variety of sources, including natural membrane environments. Given that membrane proteins represent critical drug targets, finding new ways to assess the binding and impact of drugs in these complexes is a major goal in the pharmaceutical industry. In my lecture, I will show recent results for G-protein coupled receptors and ion channels that link lipid and drug binding in these important targets.

Exploring New Heights on the Orbitrap Journey
Alexander Makarov, Director of Global Research, Life Science Mass Spectrometry, Thermo Fisher Scientific

Presentation of Orbitrap proof-of-principle at the ASMS Conference exactly 20 years ago marked the start of a long journey from a little scientific curiosity to the leading technique for high resolution accurate mass analysis. Over this time, the performance envelope of technology has been relentlessly extended and magnified by coupling with additional capabilities such as quantitative analysis, new ionization, fragmentation and signal processing methods, parallelization of detection and ion processing, and intricate coordination with different ion-optical devices. As the result, thousands of instruments of three major families are used worldwide around the clock not only for high-end -omic applications but also for screening, trace and targeted analysis by LC-MS and GC-MS.

This presentation will reveal new important steps on this journey and what the next twenty years will bring in terms of making the world healthier, cleaner, and safer.

9:30 a.m. - 12:15 p.m.
Marquis Ballroom A/B

Accelerating Insights in Structure and Function in Omics Research

Confidently determining molecular structure is increasingly becoming routinely possible on a large scale using advanced Thermo Scientific™ Orbitrap™ mass spectrometry tools. Integrated solutions for structural analysis available now shift the research focus in many laboratories from sequence to structure accelerating insights into functional aspects of biological systems. Join us in this session where our expert speakers share the newest developments in HRAM Orbitrap MS technology with applications in integrated structural protein analysis, multiplexed proteome profiling, and structural elucidation for metabolomics.

  • Performance Evaluation of a Modified Benchtop Orbitrap Instrument Equipped with a Thermo Scientific FAIMS Pro Interface for Proteomics
    Jesper Olsen, Professor, University of Copenhagen
  • Multi-omics Investigation of Colorectal Cancer Metabolism Reveals KRAS-driven Metabolic Alterations
    Peter F. Doubleday, NSF Graduate Research Fellow, Northwestern University
  • Ultrahigh Performance for Resolving Proteoforms in Targeted and Discovery Modes
    Neil Kelleher, Director, Northwestern University
  • High-throughput Identification of Novel Tomato Flavonoids by a Structure-based Profiling and Annotation Workflow
    Sheng Zhang, Director, Cornell University
  • Instant Answer: All the Data in Half the Time Using a Real-time Database Search for Isobaric Labeling Studies
    Steven Gygi, Professor, Harvard University

9:30 a.m. - 12:15 p.m.
Marquis Ballroom C

From Research to Routine: Innovations in Pharma and BioPharma

The range of Thermo Scientific advanced mass spectrometry-based workflow solutions can be applied to reveal comprehensive structural insights in pharmaceutical and biopharmaceutical discovery and development. The introduction of high resolution accurate mass MS into the routine manufacturing and quality control/lot release environment for precise drug attribute and quality monitoring is rapidly becoming a reality. To understand more about our solutions and latest technologies, join this session and hear expert speakers share their experiences in the application of mass spectrometry from research – including advanced fragmentation techniques, non-traditional separations coupled to mass spectrometry, and next-generation structural elucidation tools – to accurate and precise routine product attribute characterization and quantitation with automated sample preparation and data processing regimes.

  • Characterizing Biopharmaceuticals and Bioprocesses Using Native Thermo Scientific Orbitrap LC-MS
    Jonathan Bones, Principal Investigator, National Institute for Bioprocessing Research and Training
  • Unraveling Complex Biotherapeutics: Native Tandem Mass Spectrometry on Heterogeneous Glycoproteins and Protein Complexes
    Wendy Sandoval, Principal Scientific Manager in Research, Genentech
  • New Enzymatic Workflows for Analysis of O-Glycosylated Biopharmaceuticals
    Andreas Naegeli, Senior Scientist, Genovis
  • A New Strategy Optimized for Metabolite Profiling on Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer Platform
    Qian Ruan, Senior Research Investigator, Bristol Myers-Squibb
  • Understanding Biotherapeutic Product Quality Attributes through a Multi-Attribute Method (MAM) Lab-of-the-Future
    Andrew Dawdy, Principal Scientist, Pfizer

9:30 a.m. - 12:15 p.m.
Rooms M303-M304

Novel Mass Spectrometry Solutions in Food and Environmental Testing

Mass spectrometry and chromatographic techniques in the food and environmental industries continue to evolve, including solutions for adjacent markets. Join us during this session to hear our collaborators and guest speakers discuss how they have used Thermo Scientific LC-MS and GC-MS triple quadrupole MS and Thermo Scientific Orbitrap and Tribrid MS technologies to solve challenges in environmental testing, pesticides analysis, and food authenticity.

  • LC-MS and GC-MS Solutions for Cannabis Testing Standardization
    Garnet McRae, Technical Officer, National Research Council of Canada
  • Analysis of Silicone Wristbands Using GC Orbitrap High Resolution Mass Spectrometry to Characterize Personal Exposures
    Nicholas J. Herkert, Postdoctoral Associate, Duke University
  • Gelatin Adulteration: A Comprehensive Targeted Proteomic and Mass Spectrometry Strategy For Food Authenticity
    Francis Beaudry, Professor, University of Montréal
  • On-site Environmental Monitoring of Swiss Aquatic Systems Using a Transportable Thermo Scientific Q Exactive HF Mass Spectrometer
    Heinz Singer, Senior Scientist & Group Leader, Eawag
  • See the Pesticides You`ve Been Missing with a Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer and AcquireX
    Anastasia Kalli, Senior Product Applications Specialist, Thermo Fisher Scientific

9:30 a.m. - 12:15 p.m.
Marquis Ballroom D

Ensure a Healthier Tomorrow

The application of mass spectrometry and associated novel technologies to better understand complex diseases and new disease types continues to grow at an exponential rate. The need to detect, identify, confirm and quantify critical markers is higher than ever before. Hence, an optimal combination of advanced modern analytical technologies with innovative minds brings out effective and impactful solutions that address the most critical challenges faced by the scientists in clinical research. LC-MS on one hand offers a unique ability to leverage high resolution accurate mass for identification, characterization, confirmation, and untargeted quantitation of critical analytes regardless of their size and type. On the other hand, triple quadrupole MS enables development of sensitive, robust, reliable, and reproducible quantitation of the well characterized analytes. This session will focus on highlighting unique and novel use of LC-MS and LC-MS-based technologies for characterization to quantitation of different classes of analytes (from proteins to small molecules) in a variety of matrices (from tissues to plasma) used for clinical research.

  • VeriSpray: A High-throughput PaperSpray MS/MS System Applied to Clinical Research and Drug Screening
    Nicholas Manicke, Assistant Professor, Indiana University – Purdue University Indianapolis (IUPUI)
  • Development and Clinical Translation of the MassSpec Pen for Intraoperative Tissue Analysis
    Livia S. Eberlin, Assistant Professor and Principal Investigator, University of Texas Austin
  • Rapid Diagnostic Platform for Microbiology – Technology for Targeted Microbiome, Clinical Microbiology, and Precision Microbiology
    Ian Lewis, Assistant Professor, University of Calgary
  • Development of Biomarker Panels for Spontaneous Pre-term Birth Preeclampsia using a Novel, Exosomal Proteomics Platform
    Kevin Rosenblatt, Chief Scientific and Chief Medical Officer and Adjunct Associate Professor, NxPrenatal, Inc. and University of Texas McGovern Medical School
  • Practical Translation: Integration of Remote Biomarker Assessment in a Hospital System
    Jenny van Eyk, Director, Cedars Sinai

Our experts showed how to do more with our powerful mass spectrometry software tools. Attendees sharpened their skills, learned useful tips, and got a preview of new and exciting features in the latest versions.

Smarter. Faster. Simpler. Becoming an Orbitrap Power User.

Excited by the power and potential of your Thermo Scientific Orbitrap-based mass spectrometer? From small molecules to large, receive training on system calibration and maintenance, built-in workflows and advanced, custom method execution to allow you to increase your impact within the laboratory. Join us for first-hand demonstrations of the new features in the Tune, Method Editor, and Thermo Scientific Xcalibur applications; including AcquireX intelligent acquisition.

Agenda*

  • Registration & Continental Breakfast
  • Welcome and Introduction
  • Calibration and Preventive Maintenance
  • Instrument Control Software Overview and Software Updates
  • Xcalibur and AcquireX Updates
  • Data Acquisition Strategies for Peptide Characterization and Quantitation
  • Internal Standard-triggered Data Acquisition for Targeted Peptide Quantitation
  • RawFileReader & Xcalibur XDK Updates
  • Instrument API and XML Method Modification Interface
  • Advanced Data Acquisition with MaxQuant.Live- Florian Meier, Postdoctoral Researcher, Max Planck Institute of Biochemistry
  • TomahaqCompanion for Automated Creation of Targeted Methods that Utilize Internal Standard Peptides- Christopher Rose, Scientist, Genentech
  • Smart TMT with iAPI- Qing Yu, Postdoctoral Research Fellow, Harvard Medical School
  • Small Molecule Structure Characterization
  • Structure-based Unknown Metabolite Annotation Powered by MSn and Cutting-edge Software Tools
  • An Almanac Overview for Connected Instruments
* Topics subject to change
Powerful. Flexible. Innovative. Getting the Most from Thermo Scientific Compound Discoverer Software.

Want to get more out of Compound Discoverer software? Whether you are involved in metabolomics, environmental research, forensics, or metabolism studies, this software is the solution for small molecules. A comprehensive and flexible set of tools help you go from sample to structure, no matter what the challenge is. Join us for a discussion of the major features of Compound Discoverer software and learn about the features of the new version 3.1.

Agenda*

  • Registration and Continental Breakfast
  • Welcome and Introduction to Compound Discoverer Software
  • What’s New in Compound Discoverer 3.1 Software
  • Third-party Nodes in Compound Discoverer Software
  • Updates on mzCloud
  • Tips & Tricks, Discussion
  • Lunch
* Topics subject to change
The Present and the Future

Join the Thermo Scientific Proteome Discoverer software team to learn about topics ranging from peptide identification and quantification, to crosslinks, proteoforms, and PTM analysis. We will review in detail the recent Proteome Discoverer 2.3 software release and give a preview of the soon-to-be-released Proteome Discoverer 2.4 software. We are also pleased to host Siegfried Gessulat from TUM, who will present an overview of the PROSIT method for deep learning-based prediction of mass spectra.

Agenda*

  • Lunch and Registration
  • Welcome & Introduction to Proteome Discoverer Software: Overview of What's New in Version 2.3
  • XlinkX and TMT
  • The Latest Proteome Discoverer 2.3 Features (Continued)
  • PROSIT for Deep Learning-based Prediction of Mass Spectra
  • ProSight PD 2.0 and 3.0
  • Proteome Discoverer 2.3 (Continued) and Proteome Discoverer 2.4 Preview
  • Q&A
* Topics subject to change

Attendees our Breakfast Workshops learned from fellow scientists and Thermo Fisher Scientific experts how intelligence-driven mass spectrometry solutions enable them to drive research discoveries and perform routine tests in extraordinary ways.

Monday

Monday, June 3 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

A next-generation benchtop quadrupole-Orbitrap hybrid mass spectrometer significantly advances performance and achievable results in many important application areas, including protein profiling with FAIMS next generation ion mobility technology, quantitative protein analysis, and detailed protein characterization for translational research. Leveraging new design features, the system takes advantage of a multitude of novel ion-optical and instrument intelligence-driven design solutions that update and extend capabilities to deliver the performance, robustness, reliability, and data certainty beyond that of current high resolution mass spectrometers.

  • Introduction to Next-generation Benchtop Quadrupole-Orbitrap Hybrid Mass Spectrometer – New Platform, New Technology, Novel Capabilities
    Alexander Harder, Senior Platform Manager, Thermo Fisher Scientific
  • Intelligent Acquisition Strategies to Streamline Quantitative Proteomics
    Aaron M. Robitaille, Senior Product Applications Specialist, Thermo Fisher Scientific

Monday, June 3 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Comprehensive LC-MS-based characterization of therapeutic proteins requires detailed molecular knowledge, including primary structure, modifications, and higher order structural variation. To address the versatility and throughput requirements of comprehensive characterization, the use of a single Thermo Scientific OrbitrapMS-based analytical platform for multiple advanced characterization workflows will be described. The Multi-Attribute Method (MAM) aims to simplify and automate characterization and QC efforts. MAM is a compliance-ready method capable of monitoring multiple biopharmaceutical attributes and confirming product purity. In the pursuit of a fully automated MAM, data will be presented demonstrating the robustness and reproducibility of an automated sample preparation approach.

  • Digging Deeper in Every Direction: Developing a Next-generation Platform for High-throughput Multi-facet Protein Characterization
    Aaron Bailey, Mass Spectrometry Services Product Manager, BGI Genomics
  • The Journey to Fully Automated MAM
    Richard Rogers, Principal Scientist, Just Biotherapeutics

Tuesday

Tuesday, June 4 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

Quantitative proteomics strategies using Tandem Mass Tags (TMT) enable precise measurement of protein abundance from multiple samples into a single high-resolution LC-MS analysis. Increasingly, various biological experiments demand higher multiplexing and sample throughput with accurate quantitation. In this workshop, our expert speakers will lay out strategies that combine next generation technologies in multiplexing chemistry, hardware, and software to achieve increased quantitative performance and throughput efficiency on Thermo Scientific Orbitrap Mass Spectrometers. This includes Advanced MS2 and Advanced SPS-MS3 approaches utilizing next-generation isobaric tags, Real Time Search (RTS), and gas-phase fractionation with the Thermo Scientific FAIMS Pro interface. Together, these advances allow for intelligent acquisition methods that improve quantitation accuracy, precision, and proteome depth.

  • Going Beyond 11: Increasing Quantitative Proteomic Sample Multiplexing Using Next-generation Mass Tags and Orbitrap Mass Spectrometers
    Ryan Bomgarden, Senior Staff Scientist, Team Leader, Thermo Fisher Scientific
  • Increasing the Breadth and Depth of Multiplexed Quantitation Using Advanced Instrumentation and Methods
    Devin Karl Schweppe and Qing Yu, Postdoctoral Fellows, Harvard Medical School

Tuesday, June 4 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Untargeted metabolomics provides comprehensive coverage of the metabolome. However, challenges remain due to the chemical diversity of metabolites and confident compound annotation of biologically relevant compounds. The development of novel MS workflows with intelligent acquisition strategies and powerful data processing software increases annotation throughput. In this workshop learn how Thermo Scientific Orbitrap MS and new dual/tandem HPLC technologies reinvented the untargeted metabolomics workflow.

  • Maximizing Throughput and Metabolome Coverage with Dual Separation LC-MS
    Ioanna Ntai, Strategic Marketing Specialist, Thermo Fisher Scientific
  • High-resolution Mass Spectrometry-based Untargeted Metabolomics Method for the Identification of Glucuronide Biotransformation Products in Environmentally Exposed Fish
    Jonathan Mosley, Research Biologist, U.S. Environmental Protection Agency
  • Improving Metabolome Coverage with the Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer
    Michaela Schwaiger-Haber, Research Scientist, Washington University in St. Louis

Wednesday

Wednesday, June 5 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom ABC

Accurate monitoring of cell signaling pathway proteins has proven challenging due to the low cellular abundance of these targets and lack of standardized targeted proteomic methodologies and reagents. In this workshop, our expert speakers will share the latest advances and newest technologies in targeted peptide quantitation and pathway analysis, including our panel of Thermo Scientific SureQuant multiplex immunoprecipitation targeted mass spectrometry kits. They will also introduce the novel SureQuant internal standard triggered parallel reaction monitoring (IS-PRM) methodology for more reproducible and sensitive quantitation on Thermo Scientific Orbitrap mass spectrometers.

  • Introducing Thermo Scientific SureQuant IS-PRM, a Targeted Proteomics Methodology for Maximum Quantitative Performance - Aaron Gajadhar, Proteomics Strategic Marketing, Thermo Fisher Scientific
  • High-density Monitoring of pTyr Signaling Targets in Human Tumors Using Heavy Peptide Triggered Targeted Quantitation -Forest White, Professor, Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology

Wednesday, June 5 | 7 – 8 a.m.
Omni Atlanta at CNN Center
International Ballroom D

Structural elucidation, including metabolite identification, pharmaceutical forced degradation studies, and impurity identification are a critical part of any new drug development. In this study, degradation profiling of structurally diverse drugs was performed. Utilizing high resolution MS/MS and multistage MSn data acquisition, as well as unique workflows afforded by the acquisition system, such as automated background subtraction and isotopic filtering to trigger fragmentation, demonstrated that both MS/MS and MSn triggering rates were substantially increased. Processing increased amounts of data is the bottleneck for many small molecule applications, but with novel software tools and algorithms, confident and efficient component identification and structural elucidation were achieved with ease.

  • Tackling the Unknown Structural Elucidation Bottleneck with Mass Spectral Libraries
    Charles Cheng, Associate Director, Analytical Development Blueprint Medicines
  • Solution for Small Molecule Unknowns
    Tim Stratton, Senior Manager Software and Library Management, Thermo Fisher Scientific

Thursday

Thursday, June 6 | 7 – 8 a.m.
Georgia World Congress Center
Room A302

To understand protein functioning in the cellular environment, it is essential that researchers determine protein complex assembly and structure beyond that of individual proteins. Solving the structure of large dynamic complexes often requires integrating several complementary mass spectrometry techniques—an approach known as integrative structural biology. Thermo Fisher Scientific leads the way in accelerating protein structure-function studies with its Integrative Structural Biology solutions. In this workshop, our expert speakers will share new approaches for structural proteomics workflows.

  • New Tools for Native Mass Spectrometry: Online Separation Techniques and Complex-down Surface-induced Dissociation
    Zac VanAernum, Graduate Student, Vicki Wysocki Lab, Ohio State University
  • Applying Proteomics Principles to the Analysis of Large Complexes by HDX-MS
    Malvina Papanastasiou, Research Scientist, Broad Institute of MIT & Harvard
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We look forward to seeing you at ASMS 2020 in Houston!

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