Virtual Event
Oct 20, 2021

Ion Chromatography (IC) is the most dominant method in ion analysis and has also developed into a significant chromatographic technique within the field of separation science.

Mark your calendars on 20th October 2021 as Thermo Fisher Scientific takes you on an interactive adventure, addressing innovations and breakthroughs in ion chromatography.

   

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Speaker Lineup

Plenary Session: Computerised approaches to method development and the prediction of retention in ion chromatography

Professor Paul Haddad | Emeritus Distinguished Professor | University of Tasmania

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Professor Haddad's academic career has been spent at the Australian National University, the University of New South Wales, and since 1992 at the University of Tasmania. At UTAS he has held the positions of Head of School of Chemistry (1992) and Dean of the Faculty of Science and Engineering (1993-2001). He was an Australian Research Council Professorial Fellow from 2004-2006, and an Australian Research Council Federation Fellow from 2006-2011. He was awarded the title of Distinguished Professor in 2011. Professor Haddad served as the foundation Director of the Australian Centre for Research on Separation Science from 2001-2013 and as Director of the Pfizer Analytical Research Centre from 2006-2013. Professor Haddad is also the winner of the 2021 LCGC Lifetime Achievement in Chromatography Award, the ACS Chromatography Award, the Marcel Golay Award, the CASSS Award, and is currently an Emeritus Distinguished Professor.

The ability to predict chromatographic retention behaviour is a fundamental step in the development of new chromatographic separation methods.  Knowledge of retention times under a range of conditions enables reliable prediction of the optimal separation conditions.

There are two broad approaches that are used for prediction of retention.  The first is to derive a mathematical model relating retention time to physical and chemical parameters of the analyte, the stationary phase, and the mobile phase.  When a clear understanding exists of the mechanism by which an analyte is retained on the stationary phase and eluted by the mobile phase, it is possible to express this understanding as a mathematical retention model which can then be used to make retention time predictions. Such models are referred to as physico-chemical retention models because of their direct relationship to the physico-chemical properties of the component parts of the chromatographic system under study.  The second broad approach to the prediction of retention is the use of statistical techniques applied to large retention databases (or retention data obtained by a structured experimental design) whereby an observational relationship is determined between analyte retention time and easily measured properties of the components of the chromatographic system.  The statistical tools used to derive this observational relationship can range from simple regression through to very complex chemometric techniques.  The retention models derived using this approach are referred to as statistical retention models. 

Both physico-chemical and statistical retention models have been applied to ion chromatography (IC).  In this presentation, relevant retention models will be briefly outlined and their accuracy of prediction will be discussed, together with the ease of implementation of these models for routine use in IC method development. 

Presentation topic: Recent Innovations in Ion Chromatography

PD Dr. Joachim Weiss | Technical Director | Thermo Fisher Scientific GmbH

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After his graduation in chemistry in 1979 from the Technical University of Berlin (Germany) he worked in the field of Liquid and Gas Chromatography at the Hahn-Meitner-Institute in Berlin and received his Ph.D. in Analytical Chemistry in 1982 from the Technical University of Berlin. In 2000, Prof. Guenther Bonn appointed him Visiting Professor at the Leopold-Franzens University in Innsbruck (Austria). Weiss habilitated in Analytical Chemistry at the Leopold-Franzens University in 2002. In 2011, 2014, and 2016, Prof. Jacek Namiesnik appointed him Visiting Professor at the Technical University of Gdansk (Poland). He currently holds the position of International Technical Director for Dionex Products within the Chromatography and Mass Spectrometry Division (CMD) of Thermo Fisher Scientific, located in Dreieich (Germany).

Although ion chromatography is well matured and widely accepted today as the most dominant analytical method in ion analysis, the past decade has seen a number of exciting innovations in this field of science. Of particular importance are the new 4 µm ion-exchange packing materials, allowing method speedup or high-resolution separations. Progress in the design of cation-exchangers has been made toward new stationary phases for improved separations of amines. Electrolytic eluent generation is a well-established technique that serves as an alternative to manually prepared eluents. Recently, this concept has been expanded to the analysis of complex oligosaccharides using dual eluent generating potassium hydroxide/potassium methanesulfonate, overcoming the need to manually prepare sodium hydroxide/sodium acetate mobile phases. A major innovation in eluent suppression represents the introduction of dynamically regenerated suppressors that can work in constant voltage mode, simplifying gradient elution in anion- or cation-exchange chromatography and resulting in lower background noise. A growing number of applications are based on hyphenation for speciation analysis by coupling ion-exchange chromatography with element-specific detection via ICP. Hyphenation with ESI-MS provides the analyst with mass-selective information, which is a prerequisite for analyzing haloacetic acids, ionic pesticides, and other emerging contaminants. 

Presentation topic: ICP-MS study on elemental profiling of rice in global markets

Dr Manus Carey | Research Fellow | Institute of Global Food Security

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Dr. Manus Carey have over 30 years of experience in the field of analytical chemistry since his first job looking for pesticides in animal tissue, for the Department of Agriculture, Northern Ireland, in Dec 1990. He has expertise in sample preparation across a number of matrices from animal and human tissue, animal and human feedstuff to a large variety of environmental/geological sources. He has a high standard of analytical skill in a wide range of analytical techniques, especially various types of mass spectroscopy, including expertise in LC-MS, GC-MS, ICP-OES, ICP-MS, IC_ICP-MS, XRF and other spectrographic techniques. Dr. Manus is currently the Research Fellow in the Institute for Global Food Security, Queen’s University, Belfast.

Arsenic and its inorganic compounds are classified as class one non-threshold carcinogens, long term exposure to which causes cancer of the skin, lungs and soft tissue organs. Organic species of arsenic are considered Arsenic’s main route in to the human body is by ingestion of rice, as rice is the staple diet of over half the world’s population. Arsenic is present in rice as a combination of organic (mainly dimethylarsinic acid, DMA) and inorganic (arsenite AsIII and arsenate AsV) species and the distribution of these varying with grain origin. Here I present results from global survey of market available polished white rice, circa 1200 samples were analysed from 29 distinct sampling zones, across 6 continents. The global average for inorganic arsenic was 66 µg/kg, ranging from trace levels to 399 mg/kg. South America rice was universally high for inorganic arsenic with a mean value of 98 mg/kg, with the peak values coming from Europe at <400 mg/kg. Only southern hemisphere, eastern latitudes had truly low inorganic arsenic rice, namely East Africa and the Southern Indonesian islands. Existing agronomic methods of soil arsenic mitigation are not only expensive and labour intensive, but also scale limited. Water management techniques will reduce the inorganic arsenic uptake but attention must be paid to crop yields and other unwanted contamination, e.g. cadmium. Investigations into low uptake or arsenic resistant rice cultivars have shown some success, but many variables still exist as the diversity of soil and growing conditions around the globe preclude any clear answer. Effective treatments allow significant reductions for inorganic arsenic grain content. Novel parboiling is shown to decrease the final polished grain inorganic arsenic by 25%, while enriching the calcium content by 213%. Cooking rice with percolating hot water is shown to reduce inorganic arsenic content by up to 85%, in conjunction with standard pre-soaking and washing. These relatively low technology solutions can be applied from rural settings through to urban kitchens. The western market is reacting to the setting of guidelines and limits for inorganic arsenic content in certain foods, particularly foods aimed and children and babies. Although fewer pure rice products seemed available those tested showed lower inorganic arsenic levels, presumably by selective sourcing on behalf of the producers. Another approach was the dilution of inorganic arsenic by mixing with other grains such as maize, oats and barley. Overall this reveals the state of play, and addresses some of the avenues of mitigating inorganic in the global rice market.


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