Cryo-electron Microscopy and NanoImaging Services – Biotech Applications Workshop
Mar 28, 2019
- Mar 28, 2019
Workshop with key thought leaders regarding how Cryo-electron Microscopy unveils structures and drug discovery. Learn how to easily access Cryo-electron Microscopy.
Cryo-electron microcopy (Cryo-EM) is a Nobel Prize-winning method researchers are using to better understand structures previously too large or complex to be studied, such as viruses and protein complexes.
Cryo-EM starts with the freezing of a protein or virus sample to cryogenic temperature (below -180°C). This happens so quickly that water molecules do not have time to crystallize, which preserves the sample structure. Scientists then use a powerful cryo-transmission electron microscope (cryo-TEM) to observe the structure of these macromolecules in their natural state and create a near-atomic resolution model of them. By obtaining the 3D structures made possible by cryo-EM single particle analysis (SPA), researchers can better understand proteins, viruses and the diseases they cause.
Because of this revolutionary method, users can not only study the structure of proteins and viruses in their biologically relevant forms, but they can also observe how they interact with other macromolecules, which is the basis of every biological process. This insight allows scientists to design more effective drugs and therapies to prevent infection.
Today, researchers at leading academic and industry companies are using Thermo Scientific™ cryo-EM instruments to study and combat a wide range of serious health issues, from neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s and CTE, to cancers, malaria, HIV and other viral infections such as Zika and Ebola.
Discover how you can reduce drug development time and cost by receiving insight and conformational information about the molecular structure and interactions between drug targets and ligands.
Join us in San Diego to learn first-hand how cryo-EM and Thermo Fisher Scientific can help you in your drug discovery research and how easily you can access cryo-EM with NanoImaging Services.
Meet in the morning with our technical experts and current key thought leaders in academia and industry who will give you an overview of how invaluable cryo-EM can be to your research:
- Giovanna Scapin, Principal Scientist – Merck
- Chris Arthur, Principal Systems Specialist – Genentech
- Mark Herzik, Postdoctoral Fellow – Scripps
In the afternoon, you will able to join a tour of the NanoImaging Services facilities.
March 28, 2019
San Diego Marriott La Jolla
4240 La Jolla Village Drive
La Jolla, CA 92037
9:00 am – 9:30 am
Anke Mulder from Thermo Fisher – Kickoff & Introduce Cryo-EM
9:30 am – 10:00 am
Bridget Carragher from NanoImaging Services – Cryo-EM Innovations & Resolution Revolution
10:00 am – 10:45 am
Giovanna Scapin from Merck – Highlights and Features Her Research with Cryo-EM
10:45 am – 11:00 am
11:00 am – 11:45 am
Chris Arthur from Genentech – Highlights and Features His Research with Cryo-EM
11:45 am – 12:00 pm
12:00 pm – 12:45 pm
Mark Herzik from Scripps – Highlights and Features His Research with Cryo-EM
12:45 pm – 2:00 pm
2:00 pm – 2:20 pm
Anette Scheemann from NanoImaging Services - NIS Facilities Capabilities Intro
2:20 pm – 2:40 pm
Bus to NIS Facilities
2:40 pm – 3:40 pm
NIS Open House
3:40 pm – 4:40 pm
Bus back to Hotel
The Thermo Scientific Krios G3i Cryo Transmission Electron Microscope (Cryo-TEM) enables life science researchers to unravel life at the molecular level—easier, faster, and more reliably than ever before. Its highly stable 300 kV TEM platform and industry-leading Autoloader (cryogenic sample manipulation robot) are designed for automated applications, such as single particle analysis (SPA) and cryo-tomography.
The new Thermo Scientific Glacios Cryo Transmission Electron Microscope (Cryo-TEM) delivers a complete and affordable Cryo-EM solution to a broad range of scientists.
The Thermo Scientific Talos Arctica is a 200kV FEG transmission and scanning electron microscope (S/TEM). It is a powerful, stable, and versatile system for delivering high-resolution 3D characterization of biological and biomaterials samples in cell biology, structural biology, and nanotechnology research.
Perform the highest - quality native intact mass and top-down analysis in structural biology and biopharma research. The Thermo Scientific Q Exactive UHMR (Ultra-High Mass Range) Hybrid Quadrupole-Orbitrap Mass Spectrometer is the first UHMR MS to combine substantially increased sensitivity and mass resolution at high m/z, MS2, and psuedo-MS3 capabilities in a single platform.
Excel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer.