Unlocking New Insights with Single-Cell and Sub-Cellular Analysis
Single-cell analysis is a rapidly growing field that provides deeper insights into how diseases like cancer and infections develop and respond to treatment. Cells within the same tissue, culture, or biological fluid can be highly diverse, making traditional bulk analysis insufficient as it only provides an average value—leading to lost information.

While single-cell transcriptomics and proteomics have already advanced our understanding of infection, immunity, and drug delivery, single-cell lipidomics and metabolomics are still catching up. These approaches are crucial for studying metabolic processes at the single-cell level. Similarly, sub-cellular analysis is essential for understanding how cells reorganize in response to stressors like pathogens and radiation.

Introducing SEISMIC: Advancing Single-Cell & Sub-Cellular Analysis
The SEISMIC facility is a new multi-user research center dedicated to improving single-cell and sub-cellular measurement techniques. Working closely with bioscientists across the UK, SEISMIC leverages capillary sampling to extract live cells or sub-cellular compartments under a microscope. This technique can be paired with chromatographic separation, , which offers additional advantages in mitigating matrix effects and aiding peak assignment.

What You’ll Learn in This On-demand Webinar:

  • How live single-cell lipidomics can be achieved using capillary sampling and microfluidics.
  • The expected performance of cutting-edge mass spectrometry systems for single-cell analysis.
  • How these technologies reveal changes in cancer cell lipid profiles in response to drug and radiation treatments.
  • Progress in sub-cellular sampling for mass spectrometry-based metallomics and proteomics.

 

Register now


Speaker

Melanie Bailey

Melanie Bailey, PhD | Professor | University of Surrey

Biography

Melanie Bailey is Professor of Analytical Science at the University of Surrey. She is Director of the Wolfson Centre of Excellence for Bioanalytical Science, which brings together expertise in “omics”, biomarker discovery and imaging. This includes SEISMIC, a new BBSRC national facility for spatially resolved single and sub-cellular “omics” , new instrumentation for multimodal imaging at the UK National Ion Beam Centre and bulk metabolomics, proteomics and metallomics. She is a member of the international advisory board for The Ion Beam Analysis conference series, International Nuclear Microprobe conference series and the Bragg Institute. She is a Trustee of the Analytical Chemistry Trust Fund and ran the London Marathon to raise money for Analytical Science in 2024. She will commence a term as Editor in Chief of the Royal Society of Chemistry’s longest running journal “Analyst” in September 2024.

 

Register for this on-demand webinar now!

Style Sheet for Global Design System