Reliable solutions for all stages of vaccine development

 

 

We offer innovative solutions across the vaccine research and development workflow that help you ensure the efficacy, quality, and safety of the therapies you develop. From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides expertise and an unparalleled array of reliable and scalable tools, services, and support to help you accelerate your productivity and innovation. We invite you to partner with us to reach your vaccine development goals.

 

View our comprehensive list of products, services, and technologies to support you at every step of vaccine development:

Target discovery & functional analysisTarget discovery

Characterizing the pathogen, understanding the host response, and studying host–pathogen interactions is critical for understanding emerging disease threats and identifying variation among pathogen strains.

Featured products

Characterizing the pathogen

Viral or bacterial DNA/RNA isolation


Purify high-quality nucleic acid from a range of sample types both manually and with automated systems, using magnetic bead–based technology.

Discover more

Viral or bacterial DNA/RNA isolation with vacuum concentration


Achieve efficient concentration and preservation of heat-sensitive biological samples through solvent removal

Discover more

Sequencing solutions


Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.

Discover more

NGS library preparation kits for Illumina platforms

Enhance next-generation sequencing (NGS)-based viral surveillance with higher quality sequences and rapid protocols.

Discover more

Pathogen protein analysis


Observe biological structures in their near-native states with cryo electron microscopy techniques for structural characterization of pathogens.

Discover more

Viral proteomics & metabolomics by mass spectrometry

Mass spectrometry (MS) techniques such as proteomics, glycomics and metabolomics help advance the understanding of pathogens.

Discover more

Pathogen protein expression


High-yield expression systems for expressing recombinant pathogen proteins with more native folding and post-translational modifications

Discover more

Host-pathogen interactions and host response

Virus neutralization


High-throughput automated imaging of cell-based virus neutralization assays

Discover more

Receptors and other entry factors


Gene expression assays for viral targets including a variety of host entry factor targets.

Discover more

Tracking internalization


An extensive portfolio of cell imaging products and technologies to help researchers track the internalization of viral particles.

Discover more

High-content screening analysis


Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.

Discover more

Gene expression analysis by qPCR


Predesigned qPCR Gene Expression Assays to quantitate expression levels of immunology transcripts involved in the host response to viral infection

Discover more

NGS


Rapid, multi-dimensional genetic analysis at scale to quickly sequence DNA and RNA to understand the genetics behind viral response

Discover more

Mass spectrometry


System wide quantitative proteomics with highly sensitive and accurate mass spectrometry. Study thousands of proteins in a single experiment

Discover more

Immune response analysis by flow cytometry

Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions

Discover more

Immunoassays


Matched antibody pairs, uncoated/coated-plate ELISA kits, and multiplexing assays for the Luminex platform. Validated for reliability and specificity

Discover more

Automated reagent dispensing


Increase throughput, reproducibility, and speed through automated reagent dispensing

Discover more

Candidate vaccine synthesis & functional analysisCandidate vaccine synthesis & functional analysis

Select a suitable antigen and develop a vaccine that will provide lasting immunity by stimulating a memory T-cell response and driving memory B cell formation.

Featured products

Candidate vaccine synthesis

Attenuated vaccine


Serum-free media without compromising growth or titer. A broad selection of animal origin-free formulations that support major vaccine cell lines

Discover more

Protein subunit vaccine


Superior recombinant protein expression technology systems for consistency, high yields, and rapid protein production.

Discover more

mRNA vaccine


Breadth and depth of technologies and resources to support production. Scalable systems for mRNA synthesis, purification, formulation and delivery.

Discover more

Nucleic acid vaccine


A range of phosphoramidites and solid supports for oligonucleotide synthesis from early research to preclinical candidates.

Discover more

Functional analysis

Cell function assays


Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability

Discover more

Biodistribution assays


A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression

Discover more

Cell model creation


Closely mimic the in vivo state and generate more physiologically relevant data physiologically relevant data with complete cell culture systems for drug discovery

Discover more

Immune response analysis by flow cytometry

Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.

Discover more

Immunoassays


Antibody-based, target-specific protein quantitation reagents, kits, and panels for analysis of intracellular and cell-surface targets

Discover more

High-content screening


Platforms and software for cutting-edge images and high content imaging data in no time. Exceptional resolution with subcellular, automated detection

Discover more

Mass spectrometry


Modern, quantitative mass spectrometry analyses to detect and quantify thousands of proteins in a single experiment across multiple conditions

Discover more

CO2 incubators


Achieve your goals faster, more reliably, and with less effort, in contamination control and uniform growth conditions
 

Discover more

Candidate vaccine synthesis & functional analysisProduction process development

Solutions for producing vaccine and analytics for next stages.

Featured products

Production & purification for scale-up

Scale-up vaccine production technologies

Trusted solutions for rapid vaccine design, development, testing and production; improve quality and operational productivity and reduce costs

Discover more

mRNA vaccine production
 

Breadth and depth of technologies and resources to support production; scalable systems for mRNA synthesis, purification, formulation and delivery

Discover more

mRNA vaccine purification
 

Tailor-made affinity resin for efficient purification of mRNA constructs; scalable and suitable for commercial manufacturing

Discover more

Bioprocessing centrifugation
 

Support your applications, from R&D to large-scale production with bioprocessing centrifuges to help maximize capacity, run-to-run reproducibility, and cGMP traceability

Discover more

Impurity and contamination testing

Residual host-cell DNA quantitation

Complete solution for extraction and quantitation of host-cell DNA from biopharmaceutical purification sample matrices

Discover more

Residual plasmid quantitation

Accurate, rapid, and reproducible quantitation of residual plasmid DNA with resDNASEQ Quantitative Plasmid DNA Kit

Discover more

Adventitious virus testing

Get accurate, rapid results from a system that is part of a total workflow solution and reduce your testing challenges in a GMP environment

Discover more

Protein quantitation

An immuno-PCR based quantitation platform for sensitive and robust protein quantitation with a wide dynamic range

Discover more

Mycoplasma detection testing

Help ensure early detection of mycoplasma contamination and same day actionable results, with a sensitive real-time PCR based mycoplasma detection assay

Discover more

Microbial identification

Rapid, accurate identification of thousands of bacterial and fungal species typically in under 5 hours

Discover more

Purity test with SEC-HPLC

Separate biological molecules and polymers according to size using either SDS-PAGE / SEC-HPLC / capillary electrophoresis (reduced & nonreduced)

Discover more

Sample preparation

A universal, magnetic bead-based sample preparation technology for efficient sample clean up for reproducible contaminant and impurity testing

Discover more

Stability testing environmental chambers

Achieve testing consistency and regulatory compliance with temperature uniformity and stability

Discover more

Target discovery & functional analysisTarget discovery

Characterizing the pathogen, understanding the host response, and studying host–pathogen interactions is critical for understanding emerging disease threats and identifying variation among pathogen strains.

Featured products

Characterizing the pathogen

Viral or bacterial DNA/RNA isolation


Purify high-quality nucleic acid from a range of sample types both manually and with automated systems, using magnetic bead–based technology.

Discover more

Viral or bacterial DNA/RNA isolation with vacuum concentration


Achieve efficient concentration and preservation of heat-sensitive biological samples through solvent removal

Discover more

Sequencing solutions


Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.

Discover more

NGS library preparation kits for Illumina platforms

Enhance next-generation sequencing (NGS)-based viral surveillance with higher quality sequences and rapid protocols.

Discover more

Pathogen protein analysis


Observe biological structures in their near-native states with cryo electron microscopy techniques for structural characterization of pathogens.

Discover more

Viral proteomics & metabolomics by mass spectrometry

Mass spectrometry (MS) techniques such as proteomics, glycomics and metabolomics help advance the understanding of pathogens.

Discover more

Pathogen protein expression


High-yield expression systems for expressing recombinant pathogen proteins with more native folding and post-translational modifications

Discover more

Host-pathogen interactions and host response

Virus neutralization


High-throughput automated imaging of cell-based virus neutralization assays

Discover more

Receptors and other entry factors


Gene expression assays for viral targets including a variety of host entry factor targets.

Discover more

Tracking internalization


An extensive portfolio of cell imaging products and technologies to help researchers track the internalization of viral particles.

Discover more

High-content screening analysis


Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.

Discover more

Gene expression analysis by qPCR


Predesigned qPCR Gene Expression Assays to quantitate expression levels of immunology transcripts involved in the host response to viral infection

Discover more

NGS


Rapid, multi-dimensional genetic analysis at scale to quickly sequence DNA and RNA to understand the genetics behind viral response

Discover more

Mass spectrometry


System wide quantitative proteomics with highly sensitive and accurate mass spectrometry. Study thousands of proteins in a single experiment

Discover more

Immune response analysis by flow cytometry

Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions

Discover more

Immunoassays


Matched antibody pairs, uncoated/coated-plate ELISA kits, and multiplexing assays for the Luminex platform. Validated for reliability and specificity

Discover more

Automated reagent dispensing


Increase throughput, reproducibility, and speed through automated reagent dispensing

Discover more

Candidate vaccine synthesis & functional analysisCandidate vaccine synthesis & functional analysis

Select a suitable antigen and develop a vaccine that will provide lasting immunity by stimulating a memory T-cell response and driving memory B cell formation.

Featured products

Candidate vaccine synthesis

Attenuated vaccine


Serum-free media without compromising growth or titer. A broad selection of animal origin-free formulations that support major vaccine cell lines

Discover more

Protein subunit vaccine


Superior recombinant protein expression technology systems for consistency, high yields, and rapid protein production.

Discover more

mRNA vaccine


Breadth and depth of technologies and resources to support production. Scalable systems for mRNA synthesis, purification, formulation and delivery.

Discover more

Nucleic acid vaccine


A range of phosphoramidites and solid supports for oligonucleotide synthesis from early research to preclinical candidates.

Discover more

Functional analysis

Cell function assays


Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability

Discover more

Biodistribution assays


A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression

Discover more

Cell model creation


Closely mimic the in vivo state and generate more physiologically relevant data physiologically relevant data with complete cell culture systems for drug discovery

Discover more

Immune response analysis by flow cytometry

Simultaneously analyze multiple proteins, gene expression, and cell functions such as oxidation, viability, cell cycle, apoptosis, and proliferation.

Discover more

Immunoassays


Antibody-based, target-specific protein quantitation reagents, kits, and panels for analysis of intracellular and cell-surface targets

Discover more

High-content screening


Platforms and software for cutting-edge images and high content imaging data in no time. Exceptional resolution with subcellular, automated detection

Discover more

Mass spectrometry


Modern, quantitative mass spectrometry analyses to detect and quantify thousands of proteins in a single experiment across multiple conditions

Discover more

CO2 incubators


Achieve your goals faster, more reliably, and with less effort, in contamination control and uniform growth conditions
 

Discover more

Candidate vaccine synthesis & functional analysisProduction process development

Solutions for producing vaccine and analytics for next stages.

Featured products

Production & purification for scale-up

Scale-up vaccine production technologies

Trusted solutions for rapid vaccine design, development, testing and production; improve quality and operational productivity and reduce costs

Discover more

mRNA vaccine production
 

Breadth and depth of technologies and resources to support production; scalable systems for mRNA synthesis, purification, formulation and delivery

Discover more

mRNA vaccine purification
 

Tailor-made affinity resin for efficient purification of mRNA constructs; scalable and suitable for commercial manufacturing

Discover more

Bioprocessing centrifugation
 

Support your applications, from R&D to large-scale production with bioprocessing centrifuges to help maximize capacity, run-to-run reproducibility, and cGMP traceability

Discover more

Impurity and contamination testing

Residual host-cell DNA quantitation

Complete solution for extraction and quantitation of host-cell DNA from biopharmaceutical purification sample matrices

Discover more

Residual plasmid quantitation

Accurate, rapid, and reproducible quantitation of residual plasmid DNA with resDNASEQ Quantitative Plasmid DNA Kit

Discover more

Adventitious virus testing

Get accurate, rapid results from a system that is part of a total workflow solution and reduce your testing challenges in a GMP environment

Discover more

Protein quantitation

An immuno-PCR based quantitation platform for sensitive and robust protein quantitation with a wide dynamic range

Discover more

Mycoplasma detection testing

Help ensure early detection of mycoplasma contamination and same day actionable results, with a sensitive real-time PCR based mycoplasma detection assay

Discover more

Microbial identification

Rapid, accurate identification of thousands of bacterial and fungal species typically in under 5 hours

Discover more

Purity test with SEC-HPLC

Separate biological molecules and polymers according to size using either SDS-PAGE / SEC-HPLC / capillary electrophoresis (reduced & nonreduced)

Discover more

Sample preparation

A universal, magnetic bead-based sample preparation technology for efficient sample clean up for reproducible contaminant and impurity testing

Discover more

Stability testing environmental chambers

Achieve testing consistency and regulatory compliance with temperature uniformity and stability

Discover more

Solutions to enable a robust biotech commercialization strategy

 

Resources for navigating vaccine development processes

At the dawn of the era of precision medicine, researchers are finding new ways to develop cost-effective vaccines that target everything from viruses to cancer, using a diverse set of starting materials. From live-attenuated and inactivated to recombinant and toxoid to cutting-edge DNA vaccines, the global need for improved health outcomes is driving endless possibilities for vaccine development.

See our resources for vaccine research and development:

The Future of Vaccine Development infographic

The Future of Vaccine Development infographic

Understanding the history of vaccine development can help to accelerate the creation of future innovations efficiently and safely. Download our infographic to learn more about common challenges in vaccine development and key considerations at each stage of the workflow.

Download now

Navigating Challenges in Vaccine Development article

Navigating challenges in vaccine development article

Developing a safe and effective vaccine can be an uphill battle for biotech companies with pathogens constantly evolving, regulatory challenges, and tight timelines. Read our article to learn how novel technologies can help researchers to transverse challenges during research and development.

Read how

How to scale up and meet future healthcare needs

How to scale up and meet future healthcare needs

For many companies, COVID-19 exposed gaps and weaknesses in critical processes preventing their ability to quickly adapt or scale. In this article, we discuss ways of creating efficiencies across the pipeline to improve processes and accelerate time-to-market.

Read the article

Products and services for every stage of vaccine development

Products and services for every stage of vaccine development

From the identification, synthesis, and optimization of targets to vaccine production, delivery, and testing, Thermo Fisher Scientific provides an unparalleled array of reliable and scalable solutions and services to help you accelerate productivity across the stages of vaccine development.

View our flyer

Podcast: The Power of Transient Protein Expression in Vaccine Development

Podcast: The power of transient protein expression in vaccine development

Listen to Dr. Henry Chiou, Director of Protein and Viral Expression Systems and Transfection at Thermo Fisher Scientific, discuss how transient protein expression systems offer speed and flexibility to move candidates into clinical trials with the highest chance of success.

Listen to the podcast

Repertoire Convergence and Its Impact on Vaccine Research and Development

Repertoire convergence and its impact on vaccine research and development

Studying convergence and obtaining a deeper understanding of immune response may help improve vaccine efficacy. Read our article to learn more about convergence and the technologies that can assist researchers in studying it.

Read more

Style Sheet for Global Design System