artistic illustration representing DNA-modifying enzymes
DNA and RNA modification enzymes for every molecular biology workflow. DNA and RNA polymerases, phosphatases, kinases, nucleases and other modifying enzymes.

Featured Thermo Scientific modifying enzyme categories

Phosphatases & kinases

Alkaline phosphatase and polynucleotide kinase for DNA and RNA dephosphorylation or phosphorylation.

RNA polymerases

Properties of RNA polymerases for in vitro transcription, RNA labeling, synthesis of antisense RNA and siRNA, studies of RNA splicing and secondary structure.

Ribonucleases (RNases)

Nucleases that catalyze the degradation of RNA, used to remove RNA from DNA solutions.

Modifying Enzyme Buffers

Thermo Scientific DNA/RNA modifying enzymes are supplied with optimized reaction buffers.


Ligases catalyze the joining of nucleic acid molecules enzymatically in an ATP-dependent manner.

DNA polymerases

Mesophilic and thermophilic DNA polymerases for different polymerization reactions, DNA end-blunting and amplification, labeling and others.

Deoxyribonucleases (DNases)

Enzymes that hydrolyze phosphodiester bonds, used in various molecular biology applications.


Molecular Biology Resource Library

Webinars, videos, articles, and selection guides

Molecular Biology Web Tools

Tools for primer analysis, reaction setup, biochemical conversions, and calculators