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Chemical probes for small-molecule drug discovery
Our range of chemical probes are selective small-molecule modulators of a protein’s function, designed to allow researchers to ask mechanistic and phenotypic questions about their molecular target in cell-based or animal research studies. Selected to have known modes of action for ensuring your clinical candidates have the best chance to succeed.
Chemical probes represent an important component in both academic and pharmaceutical drug discovery research and development. These compounds help reduce the technical and biological risks of pursuing a pathway or target before incurring the time and expense of drug development and clinical trials. Chemical probes are essential in the validation of new molecular targets for a therapeutic indication.
Chemical probes in the drug discovery process
Our chemical probes enable researchers to validate the Mode of Action (MoA) of their drug candidates. This minimizes the risk of unexpected side effects in clinical trials and offers a greater probability of achieving a successful conclusion to your drug discovery program.
- Biological properties include a known MoA, high in vitro potency, high selectivity, and demonstrated on-target effects in cells
- Physicochemical properties include stability, solubility, membrane permeability, and a characterized, reproducible structure
- Excluded compounds with Pan-assay interference (PAINS) properties to avoid include covalent reactivity, redox activity, and colloidal aggregation
Frequently asked questions
For Research Use Only. Not for use in diagnostic procedures.