Search
On this page:
The industry-leading library for fragment-based drug screening
Fragment screening has become a method of choice in the quest for rapid identification of new lead molecules in drug discovery due to the higher hit probability and fewer fragments needing to be screened.
We have selected 2,500 high-quality chemical fragments from our collection of more than 30,000 to comprise the Thermo Scientific Maybridge fragment library—a proven, industry-leading library due to its diversity, pharmacophoric content, and novelty.
Extended library files now include bioactives - Released September 2025
Fragment libraries in the drug discovery process
Our solutions
- Our Maybridge Fragment Libraries contain structurally diverse compounds providing an excellent chance of finding “hits”
- Guaranteed solubility in PBS buffer enables the library to be used whatever technique you are using to screen
- The library has been pre-screened for Surface Plasmon Resonance (SPR) to ensure it is compatible with the instruments used
- Compounds with a history of providing false hits are removed so you can be sure yours are genuine
Features and benefits
- Rule of Three (Ro3) compliance delivers superior ADME attributes
- Exceptional diversity – Tanimoto similarity index of 0.66 based on standard Daylight fingerprinting
- PAINS Free – The library has been filtered to remove pan assay interference compounds (PAINS) avoiding false hits
- Experimentally measured solubility – guaranteed solubility of fragments in PBS buffer (1mM) ensures robust screening data and minimizes candidate attrition
- Optimised for SPR – in collaboration with Cytiva Healthcare a “Clean Screen” was run on a Biacore instrument to remove promiscuous binders
For Research Use Only. Not for use in diagnostic procedures.