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Monomers (Building Blocks) for Hit to Lead Optimization

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Designed to facilitate hit to lead optimization through structure activity relationship work

The availability of diverse and pharmacophorically relevant synthetic building blocks remains a critical success factor in the drug design process. Where key building blocks are not commercially available, in-house synthesis consumes vital time and can add considerable cost to the project.

 

Our focus is to provide medicinal chemists with the ideal building blocks for use in early-phase drug discovery in:

  • Structure activity relationship (SAR) development
  • Generating screening libraries for further hit identification/elaboration

Our extensive range of medicinally relevant building blocks are specifically designed for lead optimization through structure activity relationship (SAR) development.  

Monomers in the drug discovery process

Solutions

  • Enhances the pharmacophoric profile of your target molecules

  • Facilitates the full breadth of chemical synthesis techniques

  • Enables systematic exploration of structural diversity space

  • Provides easier interpretation of  SAR

Benefits

  • Over 25,000 building blocks containing more than 300 different heterocyclic ring systems

  • Support all synthetically useful functional groups

  • Provide all possible ring regioisomers

  • Compounds have minimal additional substitution

Optimize your workflow

Download the library files

Frequently asked questions

This extensive set comprises more than 25,000 building blocks encompassing over 300 distinct heterocyclic frameworks. Each scaffold is designed for synthetic versatility and offered in multiple ring configurations, providing broad coverage of chemical space and facilitating clear SAR analysis.

 

Explore the library

For Research Use Only. Not for use in diagnostic procedures.