Closed, scalable electroporation system for GMP-compliant cell therapy manufacturing

The CTS Xenon Electroporation System offers reliable delivery of DNA, RNA, proteins, and other molecules into cells, with exceptional cell viability and recovery. This leads to efficient transfection and genome editing, even in hard-to-transfect cells. A choice of two single-use electroporation chambers of different capacities provides flexibility: the SingleShot chamber enables process development while the MultiShot cartridge can be used in a closed, commercial-scale transfection system that minimizes contamination and human error while maximizing safety.


Process- and protocol-compatible with the Invitrogen Neon Transfection System, the Xenon system helps enable smooth scale-up from research to process development to commercial manufacturing of up to 25 mL at a time. Pair it with other Thermo Fisher Scientific instruments to assemble a closed, integrated, GMP-compliant workflow that can be controlled by process automation software.


Robust transfection

The Xenon Electroporation System offers reliably high transfection performance in volumes of up to 25 mL in less than 25 minutes with exceptional cell viability and recovery.

Stacked bar graph showing high percentage of cell viability following electroporation with the Xenon system.

Closed system

Together, the Xenon Electroporation instrument, MultiShot cartridge, buffers, and software comprise a GMP-manufactured, closed cell electroporation system that minimizes contamination and maximizes safety.

Offset photo of a single-use plastic device meant to aseptically hold up to 25 mL of cells for electroporation in the Xenon system.

Seamlessly scalable

Transition from research and early development on the small-scale Neon Transfection System (pictured) to process development and GMP manufacturing on the Xenon system using the same protocol without reoptimization.

Offset photo of the Neon benchtop device, a research-use small-scale electroporation system.

Integrated workflow

The Xenon system can be integrated with other Thermo Fisher Scientific instruments and consumables into a complete, closed cell therapy manufacturing workflow.

Several large benchtop devices arranged in a line in a laboratory to depict a typical cell therapy workflow.

Clinical manufacturing mode

Lock down protocols for commercial manufacturing and add electronic record-keeping software to enable FDA 21 CFR Part 11 compliance.


Screenshot of an onboard touchscreen depicting conversion to clinical manufacturing mode.

Intended use of the products mentioned on this page varies. For specific intended use statements, please refer to the product label.