TrueMark Infectious Disease Research Panels

A flexible, scalable, and reliable solution for lab optimization utilizing real-time PCR instrumentation

With the unpredictable, rapidly changing nature of SAR-CoV-2, labs are expanding their test menus to accommodate a growing number of infectious disease areas and finding ways to improve the precision and accuracy of their testing technology. Detection of common infectious diseases with traditional culture- or microscopy-based methods are antiquated and lack sensitivity and specificity. Real-time PCR (qPCR) is an innovative solution for detecting slow-growing, difficult-to-cultivate, or uncultivable microorganisms.

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Applied Biosystems TrueMark Infectious Disease Research Panels are convenient, duplexed TaqMan assays that are performed on pre-spotted and dried-down plates that include microorganism‑specific pathogens, utilizing real‑time PCR techniques.

This enables rapid, accurate detection and categorization of microorganisms that cause respiratory, vaginal, urinary, gastrointestinal, and sexually transmitted diseases, as well as antibiotic resistance testing.

Benefits of the TrueMark Panels

• Customizable—choose from a selection of predefined panels or customer-defined panels
• Ease-of-use—convenient, duplexed reactions include assay and positive control, pre-spotted and dried down on TaqMan plates, designed for easy set-up and increased accuracy; just add sample and approved TaqPath Master Mix
• Expanded content—pathogen detection panels available for respiratory, urinary, gastrointestinal, vaginal, and sexually transmitted infections, as well as antibiotic resistance assays
• Endogenous controls—duplex reactions offer RNase P human internal control or Bacillus atrophaeus bacterial spike-in control* in every well for added confidence
• Amplification control—TaqMan Comprehensive Microbiota Control covers all targets in RTI, UTI, STI, and vaginal panels, making it easier to validate and perform routine testing

Benefits of molecular testing

• Increased sensitivity—more specific, accurate, and precise compared to traditional culture and microscopy methods
• Timely results—results from PCR testing are more accurate than traditional methods, which are manual

Benefits of buying from Thermo Fisher Scientific

• Complete end-to-end solution—optimized for use on QuantStudio qPCR systems with verified sample-to-answer workflow
• Expertise in assay design—run comprehensive molecular testing panels with assays optimized for maximal strain coverage, sensitivity, and internal control
• Comprehensive service and support—analytical validation consultation and training services available to help implement solutions with ease

Maximize your workflow

Expand from SARS-CoV-2 testing to TrueMark Infectious Disease Research Panels utilizing the same workflow, with our custom, made-to-order, or predefined panels on TaqMan Array Plates for 96-well and 384-well panels which are compatible for use on QuantStudio qPCR systems. Go from sample to result in approximately four hours.

TrueMark Infectious Disease Research Panels are a collection of duplex assays that detects microbes and internal controls in the same reaction. Customers have the option of predefined panels on 96-well plates or custom assay options on either 96-or 384-well plates.

Duplexed assays 

• Allow for the simultaneous detection of target and control in the same well
• Help increase confidence in results
• Are designed to reduce the need to run replicates, helping to lower cost and minimize workflow complexity

Pre-spotted and dried down plates

• Target and RNAse P process control assays dried down in plate 
• Designed to reduce hands on time and errors in the workflow

Amplification control

• One control covers all disease area targets, panels, and applications
• Makes it easier for labs to validate and perform routine testing

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Increased productivity, sensitivity, and specificity with qPCR technology

Implementing genetic analysis systems and solutions in the laboratory has been directly linked to improved efficiencies, cost savings, and faster time to reportable results.** qPCR can detect slow-growing, difficult-to-cultivate microorganisms, making it ideal for when culture methods are inadequate, ambiguous, time-consuming, difficult, or costly.

Analytical validation consultation services

To help you implement this workflow into your laboratory with ease, we offer analytical validation consultation services—potentially reducing your overall time to test launch up to 75%.
Our analytical validation consulting services provide clinical testing labs with fast and cost-effective validation of real-time PCR (qPCR) assays and panels on Applied Biosystems
TaqMan Array Plates that follow industry quality standards and regulatory guidelines. A typical validation can take anywhere from 6–12 months for DIY customers; however, we
can help labs complete their validation process with TaqMan Array Plates an average of up to 75% faster than they could on their own.

Our team also offers workflow training to enable your success.

*Spike in the Applied Biosystems TaqMan Universal Extraction Control Organism (Cat. No. A39180) containing Bacillus atrophaeus for use as a process control.
** Davenport et al. (2017) New and developing diagnostic technologies for urinary tract infections. Nat Rev Urol. volume 14, pages 296–310.
***Control needs to be manually pipetted into each well
† Available in predefined or custom panels.
‡ Available only as custom panel option; contact your sales representative or customer service for more information.