Cytogenetic/copy number analysis with microarrays

Microarrays are an ideal platform for copy number variation (CNV) analysis and molecular cytogenetic research. Our microarray-based assays are a reliable genome-wide approach for high-resolution DNA copy number analysis to detect gains, losses, loss of heterozygosity (LOH)/absence of heterozygosity (AOH), copy-neutral loss of heterozygosity (cnLOH), regions identical-by-descent, and mosaicism. Quickly and easily identify aneuploidies, microdeletions, microduplications, as well as other types of chromosomal aberrations across the genome.

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CytoScan HD Suite
CytoScan-HD products

The CytoScan HD Suite is a whole-genome microarray solution comprised of array, reagents, software, and instrument designed for both SNPs and non-polymorphic probes, providing broad coverage and high performance for detecting chromosomal aberrations with greater than 99% sensitivity.

  • A balanced whole-genome microarray with hybrid design, including both copy number probes and SNPs for improved confidence.
  • Covers all genes in the genome.
  • Offers exceptional performance with high sensitivity, specificity, dynamic range, and resolution across the genome.
  • Provides sensitive mosaic detection and streamlined data analysis.

CytoScan HD Suite is the unrivaled standard in cytogenetics analysis and delivers with:

Exceptional performance-coverage without compromise

Provides the broadest coverage and highest performance for detecting chromosomal aberrations. CytoScan HD Suite has greater than 99% sensitivity and can reliably detect 25-50 kb copy number changes across the genome at high specificity with single-nucleotide polymorphism (SNP) allelic corroboration. With more than 2.6 million copy number markers, CytoScan HD Suite covers all OMIM and RefSeq genes.

High-density SNPs with >99% genotype accuracy

Enables low-level mosaicism visualization, absence of heterozygosity (AOH) and acquired UPD (aUPD) detection, copy number change confirmation, triploidy detection, and more.

The broadest range of sample types supported—including POC FFPE

Supports several different sample types for cancer and constitutional cytogenetic analysis, including blood, bone marrow, buccal, saliva, fresh and frozen tissues, DBS cards, direct/cultured cells, amniocytes, and products of conception (POC), fresh and formalin-fixed, paraffin-embedded non-archived samples among others.

Robust manual or automated assay workflows: DNA to result in less than three days

Optimized to save laboratory time, money, and resources. The CytoScan protocol can be accomplished in 2.5 days with just 7 hours of hands-on time.

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Chromosome Analysis Suite (ChAS)

Chromosome Analysis Suite is a software offering intuitive and flexible workflow for accurate analysis tailored for cytogenetics. ChAS was developed with input from leading experts and is customized for copy number and cytogenetics research analysis and reporting. ChAS enables you to view and summarize chromosomal aberrations across the genome. Chromosomal aberrations may include copy number gain or loss, mosaicism, or loss/absence of heterozygosity (LOH/AOH).

Histogram track view

Figure 2. Histogram track view.

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Are you trying to learn more about how to deal with rare and challenging prenatal case? The Cytogenomics Array Group CNV Database (CAGdb) may be the answer.

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