Validation studies show that AST testing with Sensititre plates and Oxoid discs aligns closely with EUCAST and CLSI standards. Output from SWIN software shows the kind of guidance and reports customers can expect when using Sensititre MIC plates and instruments.
Additional validation studies. The EUCAST development laboratory (EDL) evaluated 21 commercial Mueller–Hinton (MH) dehydrated agar preparations from 17 manufacturers for disc diffusion AST testing. Oxoid MH Agar was one of six preparations that “demonstrated excellent performance, with ≥99% of zone diameter readings within QC ranges and ≥70% on target ±1 mm.” In the study, EDL noted that “discs from Oxoid (Thermo Fisher Scientific) were used due to their accurate and reproducible performance in a previous disc evaluation study” as cited above.
Åhman J, Matuschek E, Kahlmeter G. EUCAST evaluation of 21 brands of Mueller–Hinton dehydrated media for disc diffusion testing. Clin Microbiol Infect. 2020; 26: 1412.e1-1412.e5. Full text
Additional validation studies. Researchers from France and Switzerland tested 185 Gram-negative clinical isolates on three commercialized broth microdilution systems for colistin susceptibility. They concluded that “the Sensititre system was the most reliable marketed BMD panel with a categorical agreement of 97.8%.”
Jayol A, Nordmann P, André C, Poirel L, Dubois V. Evaluation of three broth microdilution systems to determine colistin susceptibility of Gram-negative bacilli. J Antimicrob Chemother. 2018; 73: 1272-1278. PubMed
 Humphries RM, Ambler J, Mitchell SL, et al. CLSI Methods Development and Standardization Working Group best practices for evaluation of antimicrobial susceptibility tests. J Clin Microbiol. 2018; 56: e01934-17. PubMed
When you use the Sensititre System, data appears right on the screen. The SWIN software interprets the microbial growth in each well as Susceptible (S, green), Resistant (R, red), or Intermediate (I, yellow) according to the breakpoints set by the regulatory body you have chosen. Clinicians have the option to alter the software interpretation based on their clinical judgment.
Clinical reports from SWIN software include MIC values and interpretations based on CLSI or EUCAST breakpoints as chosen by the user at setup. Comments from the Expert System reflect on CLSI or EUCAST recommendations and are keyed to individual results.
When you run a quality control (QC) test on a Sensititre plate, SWIN software outputs complete MIC results for each antimicrobic and QC strain, alongside its acceptable regulatory standard. The report also includes a Pass or Fail grade on five different test elements.
Regulatory status varies by product and region. Please consult individual product pages.