Clinical Research & Toxicology Peer-Reviewed Literature Library

Mass spectrometry-based discoveries in clinical and translational research

Thermo Fisher Scientific customers all over the world are using our instruments and other products to make critical progress in clinical application areas such as endocrinology, therapeutic drug monitoring, clinical biomarkers, translational research and forensics and toxicology. Click on the topics below to see related scientific publications in peer-reviewed journals.

Toxicology

Quantitative

Title Analyte Technique
 Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry. synthetic cathinones, metabolites HRAM MS
 Buprenorphine detection in urine using liquid chromatography-high-resolution mass spectrometry: comparison with cloned enzyme donor immunoassay (ThermoFisher) and homogeneous enzyme immunoassay (immunalysis). buprenorphine HRAM MS
 Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse. cytochrome P450 HRAM MS
 Analysis of drugs of abuse by online SPE-LC high resolution mass spectrometry: communal assessment of consumption. drugs of abuse HRAM MS
 The use of turbulent flow chromatography for rapid, on-line analysis of tryptic digests. tryptic drugs HRAM MS
 Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking. heterocyclic amines 2-amino-9H-pyrido[2,3-b]indole, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, e-cigarette Triple Quadrupole MS
 Rapid determination of nine barbiturates in human whole blood by liquid chromatography-tandem mass spectrometry. barbiturates Triple Quadrupole MS
 Liquid chromatography-high resolution-tandem mass spectrometry using Orbitrap technology for comprehensive screening to detect drugs and their metabolites in blood plasma. drugs, drug metabolites HRAM MS
 Use of LC-HRMS in full scan-XIC mode for multi-analyte urine drug testing - a step towards a 'black-box' solution? psychoactive substances, NPS HRAM MS
 High-Throughput Screening and Quantitation of Target Compounds in Biofluids by Coated BladeSpray-Mass Spectrometry. anabolics, stimulants, diuretics, narcotics Triple Quadrupole MS
 A liquid chromatography and tandem mass spectrometry method to determine 28 non-volatiledrugs of abuse in exhaled breath. drugs, volatile drugs Triple Quadrupole MS
 Dilute-and-shoot coupled to nanoflow liquid chromatography high resolution mass spectrometry for the determination of drugs of abuse and sport drugs in human urine. DOA, drugs of abuse HRAM MS
 Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice. e-cigarette Triple Quadrupole MS
 Quantitative analysis of dextran in rat plasma using Q-Orbitrap mass spectrometry based on all ion fragmentation strategy. dextran HRAM MS
 A UHPLC-MS/MS method for the quantification of Δ9-tetrahydrocannabinol and cannabidiol in decoctions and in plasma samples for therapeutic monitoring of medical cannabis. THC, tetrahydrocannabinol Triple Quadrupole MS
 Adsorption of tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl)-1-butanone from aqueous solution with graphene aerogel nitrosamine; tobacco-specific Triple Quadrupole MS
 Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry. oxytocin, fatty acyl, lipids HRAM MS

Screening

Title Analyte Technique
 Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular  drug screening HRAM MS 
 Fully automated semi-quantitative toxicological screening in three biological matrices using turbulent flow chromatography/high resolution mass spectrometry. drugs of abuse HRAM MS
 First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry. PV8, pyrrolidinophenone, drugs, novel psychoactive substances, NPS HRAM MS
 LC-HR-MS/MS standard urine screening approach: Pros and cons of automated on-line extraction by turbulent flow chromatography versus dilute-and-shoot and comparison with established urine precipitation. drugs, metabolites HRAM MS
 Comprehensive analysis by liquid chromatography Q-Orbitrap mass spectrometry: Fast screening of peptides and organic molecules. peptides, organic compounds, DOA HRAM MS
 Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances. psychoactive substances, NPS HRAM MS
Translational research
Title Analyte Technique
 Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): a novel glycan-relative quantification strategy. INLIGHT, isotope glycan hydrazide tags HRAM MS
 Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometer. SILAC, mTRAQ, phosphoproteoomics HRAM MS
 Overcoming challenges and opening new opportunities in glycoproteomics. glycoproteomics HRAM MS
 Collagen peptides in urine: a new promising biomarker for the detection of colorectal liver metastases. peptides HRAM MS
 A direct-infusion- and HPLC-ESI-Orbitrap-MS approach for the characterization of intact PEGylated proteins. PEGylated protein HRAM MS
 Stable, reproducible, and automated capillary zone electrophoresis-tandem mass spectrometry system with an electrokinetically pumped sheath-flow nanospray interface. proteins HRAM MS
 Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis. proteome HRAM MS
 Deep proteomic profiling of human carotid atherosclerotic plaques using multidimensional LC-MS/MS. proteome HRAM MS
 Glycoform analysis of recombinant and human immunodeficiency virus envelope protein gp120 via higher energy collisional dissociation and spectral-aligning strategy. glycoform, protein gp120 HRAM MS
 Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer. proteome HRAM MS
 Using In-Solution Digestion, Peptide Fractionation, and a HRAM MS Mass Spectrometer to Analyze the Proteome of Clathrin-Coated Vesicles proteome of clathrin-coated vesicles HRAM MS
 Urine sample preparation in 96-well filter plates to characterize inflammatory and infectious diseases of the urinary tract. proteins HRAM MS
 Comparative reevaluation of FASP and enhanced FASP methods by LC-MS/MS. proteins HRAM MS
 A Double-Barrel Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) System to Quantify 96 Interactomes per Day. proteome HRAM MS
 Quantification of cytokines secreted by primary human cells using multiple reaction monitoring: evaluation of analytical parameters. cytokines HRAM MS
 A novel and sensitive assay for heme oxygenase activity protein Triple Quadrupole MS
 Solid-phase extraction of small biologically active peptides on cartridges and microelution 96-well plates from human urine peptides Triple Quadrupole MS
 Quantitative Site-Specific Phosphoproteomics of Trichoderma reesei Signaling Pathways upon Induction of Hydrolytic Enzyme Production. phosphoproteomics HRAM MS
 Implementation of Ultraviolet Photodissociation on a Benchtop HRAM MS Mass Spectrometer and Its Application to Phosphoproteomics. phosphoproteomics HRAM MS
 Selecting Optimal Peptides for Targeted Proteomic Experiments in Human Plasma Using In Vitro Synthesized Proteins as Analytical Standards. peptides Triple Quadrupole MS
 Constructing Proteome Reference Map of the Porcine Jejunal Cell Line (IPEC-J2) by Label-Free Mass Spectrometry. proteome HRAM MS
 Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays. peptides Triple Quadrupole MS
 Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays. peptidase, human kallikrein-related peptidase HRAM MS, Triple Quadrupole MS
 Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion. streptococci captures HRAM MS, Triple Quadrupole MS
 Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System. proteins Triple Quadrupole MS
 Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis. elF4G Triple Quadrupole MS
 Longitudinal investigation of salivary proteomic profiles in the development of early childhood caries. peptides HRAM MS
 Exploring ECD on a Benchtop HRAM MS Orbitrap Mass Spectrometer. bottom-up proteomics, ECD utility HRAM MS
 Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach. proteins, brain Triple Quadrupole MS
 Ultra-High-Resolution Mass Spectrometry for Identification of Closely Related Dermatophytes with Different Clinical Predilections. proteins, top-down, fungi HRAM MS
 Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications. proteins, brain Triple Quadrupole MS
 Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry. proteome Triple Quadrupole MS
 Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry. proteome Triple Quadrupole MS
 Acute Proteomic Changes in the Lung after WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure. proteome HRAM MS
 iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy. biomarkers, proteins HRAM MS
Clinical research biomarkers
Title Analyte Technique
 Matrix-assisted laser desorption/ionization for simultaneous quantitation of (acyl-)carnitines and organic acids in dried blood spots. acylcarnitines, carnitines, organic acids HRAM MS
 An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM). insulin, insuline analogs HRAM MS
 Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry. anionic metabolites HRAM MS
 Large-scale label-free comparative proteomics analysis of polo-like kinase 1 inhibition via the small-molecule inhibitor BI 6727 (Volasertib) in BRAF(V600E) mutant melanoma cells. polo-like kinase 1, BI6727, Volasertib, BRAF, V600E HRAM MS
 A strategy for sensitive, large scale quantitative metabolomics. metabolomics HRAM MS
 Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3. NOX4, ITGA3 HRAM MS
 Simultaneous quantification of Sphingolipids in small quantities of liver by LC-MS/MS sphingolipids Triple Quadrupole MS
 Underivatized oxysterols and nanoLC-ESI-MS: A mismatch. oxysterols HRAM MS, Triple Quadrupole MS
 Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry. 25-hydroxy vitamin D HRAM MS
 Detection and quantification of proteins in clinical samples using high resolution mass spectrometry. protein, biomarker HRAM MS
 High speed capillary zone electrophoresis-mass spectrometry via an electrokinetically pumped sheath flow interface for rapid analysis of amino acids and a protein digest. amino acid, proteins HRAM MS
 Targeted Metabolomic Analysis of Head and Neck Cancer Cells Using High Performance Ion Chromatography Coupled with a HRAM MS HF Mass Spectrometer. targeted metabolomics HRAM MS
 MS2PIP prediction server: compute and visualize MS2 peak intensity predictions for CID and HCD fragmentation. prediction models for fragmentation HRAM MS
 Analysis of Cell Metabolism Using LC-MS and Isotope Tracers. metabolism HRAM MS
 Measurement of Lung Phosphatidylcholines in Exhaled Breath Particles by a Convenient Collection Procedure. phosphatidylcholines Triple Quadrupole MS
 Metabolism of human insulin after subcutaneous administration: A possible means to uncover insulin misuse. insulin, insulin metabolites HRAM MS
 Histamine quantification in human plasma using high resolution accurate mass LC-MS technology. histamine HRAM MS
 Sensitive, Simple, and Robust Nano-Liquid Chromatography-Mass Spectrometry Method for Amyloid Protein Subtyping. amyloid protein HRAM MS
 Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. oxysterols HRAM MS
 In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant. α-pyrrolidinopentiothiophenone HRAM MS
 Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in AlzheimerDisease and Frontotemporal Lobar Degeneration. visinin-like protein Triple Quadrupole MS
 Development and Evaluation of a Parallel Reaction Monitoring Strategy for Large-Scale Targeted Metabolomics Quantification. metabolites HRAM MS
 Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics. PEGylated protein HRAM MS
 Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells. protein, estrogen receptor HRAM MS, Triple Quadrupole MS
 Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery. thromboxane Triple Quadrupole MS
 Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease. APOE, apolipoprotein Triple Quadrupole MS
 Associations between calcium-phosphate metabolism and coronary artery calcification; a cross sectional study of a middle-aged general population. parathyroid hormone (PTH) and 25-hydroxyvitamin D Triple Quadrupole MS
 Transfer of developmental neurotoxin β-N-methylamino-l-alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis. BMAA, neurotoxin Triple Quadrupole MS
 Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring angiotensin II-regulated proteins Triple Quadrupole MS
 Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. carboxyl ester lipase (CEL) Triple Quadrupole MS
 An analytical strategy to investigate Semen Strychni nephrotoxicity based on simultaneous HILIC-ESI-MS/MS detection of Semen Strychni alkaloids, tyrosine and tyramine in HEK 293t cell lysates. semen strychini alkaloids, tyrosine, tyramine HRAM MS
 Simultaneous Determination of Multiple Intracellular Primary Metabolites by Ultrahigh Performance Liquid Chromatography Coupled with a HRAM MS HF Mass Spectrometer. primary metabolites HRAM MS
 Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. biomarkers, polar metabolites, lipids HRAM MS
 Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus. plasmalogen Triple Quadrupole MS
 25C‐NBOMe and 25I‐NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high‐resolution mass spectrometry 25C-NBOMe, 25I-NBOMe HRAM MS
 Determination of amino acids in colon cancer cells by using UHPLC-MS/MS and [U-13C5]-glutamine as the isotope tracer. amino acids Triple Quadrupole MS
 Identification and Characterization of Cardiac Troponin T Fragments in Serum of Patients Suffering from Acute Myocardial Infarction. biomarker, cardiac troponin T HRAM MS
 Identification and quantitation of phosphatidylethanols in oral fluid by liquid chromatography-tandem mass spectrometry. phospatidylethanol Triple Quadrupole MS
 A Nontargeted UHPLC-HRMS Metabolomics Pipeline for Metabolite Identification: Application to Cardiac Remote Ischemic Preconditioning. biomarkers HRAM MS
 Expanding the knowledge on dried blood spots and LC-MS-based protein analysis: two different sampling materials and six protein targets. protein HRAM MS, Triple Quadrupole MS
 Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure. protein, biomarker HRAM MS
 Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. fructose 1,6-biphosphate, aldose mediate glucose Triple Quadrupole MS
 Quantification of xanthine- and uric acid-related compounds in urine using a "dilute-and-shoot" technique coupling ultra-high-performance liquid chromatography and high-resolution Orbitrap mass spectrometry. xanthine, uric acid HRAM MS
 Holistic Lipidomics of the Human Gut Phenotype Using Validated Ultra-High-Performance Liquid Chromatography Coupled to Hybrid Orbitrap Mass Spectrometry. fatty acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, sterols HRAM MS
 Lower plasma choline levels are associated with sleepiness symptoms. choline Triple Quadrupole MS
 Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaMSites to Activation. AMPK Triple Quadrupole MS
 Easy, Fast, and Reproducible Quantification of Cholesterol and Other Lipids in Human Plasma by Combined High Resolution MSX and FTMS Analysis. cholesterol, glycerolipids, sphingolipids, sterol esters HRAM MS
 Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells. peptides Triple Quadrupole MS
 Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing. amino acid, lipid Triple Quadrupole MS
 Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry. dinnutuximab Triple Quadrupole MS
 N6-(2-Deoxy-d- erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5- N-(2-hydroxy-3-buten-1-yl)-formamidopyrimidine Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells. nucleobase adducts Triple Quadrupole MS
 Rapid detection and quantification of aminoglycoside phosphorylation products using direct‐infusion high‐resolution and ultra‐high‐performance liquid chromatography/mass spectrometry aminoglycoside phosporylation products HRAM MS
 Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression. pentraxin receptor Triple Quadrupole MS
 Total Fatty Acid Analysis of Human Blood Samples in One Minute by High-Resolution Mass Spectrometry. fatty acids HRAM MS
 Bioactive Lipids in Sputum of Older Adults with Asthma as Potential Markers of Disease Phenotypes lipids Triple Quadrupole MS
 How do cancer-sniffing dogs sort biological samples? Exploring case-control samples with non-targeted LC-Orbitrap, GC-MS, and immunochemistry methods. biomarkers, polar metabolites, lipids HRAM MS
 A validated multi-matrix platform for metabolomic fingerprinting of human urine, feces and plasma using ultra-high performance liquid-chromatography coupled to hybrid orbitrap high-resolution mass spectrometry. biomarkers HRAM MS
 Rapid analysis of pyridinoline and deoxypyridinoline in biological samples by liquid chromatography-mass spectrometry and silica hydride column. pyridinoline, deoxypyridinoline HRAM MS
 Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer. lipids HRAM MS
 Plasma free metanephrines for diagnosis of neuroblastoma patients. metanephrines, plasma free metanephrines Triple Quadrupole MS
 Strain-Level Differentiation of Bacteria by Paper Spray Ionization Mass Spectrometry. bacteria HRAM MS
 Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome. untargeted, amino acids, sphingolipids, fatty acids HRAM MS, Triple Quadrupole MS
 An Integrated Approach to Characterize Intestinal Metabolites of Four Phenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant Activity Evaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay. biomarkers HRAM MS
 Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis. biomarkers HRAM MS
 Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. proteomes, lipids HRAM MS
Endocrinology
Title Analyte Technique
 An optimized method for neurotransmitters and their metabolites analysis in mouse hypothalamus by high performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry. neurotransmitters, hypothalamus, neurotransmitter metabolites HRAM MS
 Simultaneous quantification of neuroactive dopamine serotonin and kynurenine pathway metabolites in gender-specific youth urine by ultra performance liquid chromatography tandem high resolution mass spectrometry. dopamine, serotonin, kynurenine pathway metabolites HRAM MS
 Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester. resveratrol effects on steroidogenesis Triple Quadrupole MS
 Quantification of steroid hormones in human serum by liquid chromatography-high resolution tandem mass spectrometry. steroid hormones HRAM MS
 Comparative limitations and benefits of liquid chromatography - mass spectrometry techniques for analysis of sex steroids in tears. steroids HRAM MS
 A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids. progestins, steroids HRAM MS
Therapeutic drug monitoring
Title Analyte Technique
 Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS assay. teicoplanin HRAM MS
 The development and validation of a method using high-resolution mass spectrometry (HRMS) for the qualitative detection of antiretroviral agents in human blood. antiretroviral drugs, HIV drugs HRAM MS
 Assessment of tandem mass spectrometry and high-resolution mass spectrometry for the analysis of bupivacaine in plasma. bupivacaine Triple Quadrupole MS, HRAM MS
 A high-resolution accurate mass (HR/AM) approach to identification, profiling and characterization of in vitro nefazodone metabolites using a hybrid quadrupole Orbitrap (Q-Exactive). nefazodone metabolites HRAM MS
 Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry. acetomenophen, alicylic acid HRAM MS
 Quantification of active infliximab in human serum with liquid chromatography–tandem mass spectrometry using a tumor necrosis factor alpha -based pre-analytical sample purification and a stable isotopic labeled infliximab bio-similar as internal standard: infliximab Triple Quadrupole MS
 Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide. phenobarbital, phenytoin, carbamazepine HRAM MS
 Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. drugs, antihypertensive HRAM MS
 Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices. efavirenz Triple Quadrupole MS
 Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. tacrolimus, immunosuppressant Triple Quadrupole MS
 Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment. trastuzumab Triple Quadrupole MS
 Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. tacrolimus, sirolumus, everolimus, cyclosporin A, mycophenolic acid Triple Quadrupole MS
 Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry. voriconazole Triple Quadrupole MS
 LC-MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs. Fab-bound colchicine, Fab fragments Triple Quadrupole MS
 Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry. voriconazole Triple Quadrupole MS
 Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Qexactive high-resolution benchtop quadrupole orbitrap mass spectrometer. larotaxel HRAM MS
 Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry. benzodiazepines flubromazolam, pyrazolam HRAM MS
 Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). ISD, immunosuppressive drugs Triple Quadrupole MS
 Development and validation of a liquid chromatography/tandem mass spectrometry method for determination of caspofungin in dried blood spots. capsofungin Triple Quadrupole MS
 Development and validation of a targeted affinity-enrichment and LC-MS/MS proteomics approach for the therapeutic monitoring of adalimumab. adalimumab HRAM MS
 An LC-MS/MS method for quantification of daptomycin in dried blood spot: Application to a pharmacokinetics study in critically ill patients daptomycin Triple Quadrupole MS
Orthogonal techniques

Gas chromatography

Title Analyte Technique
 Development of a HS-SPME/GC–MS method for the analysis of volatile organic compounds from fabrics for forensic reconstruction applications VOCs for forensic use HRAM GC-MS
 Non-targeted acquisition strategy for screening doping compounds based on GC-EI-hybrid quadrupole-Orbitrap mass spectrometry: focus on exogenous anabolic steroids anabolic steroids HRAM GC-MS
 Development of a high-throughput screening analysis for 288 drugs and poisons in human blood using Orbitrap technology with gas chromatography-high resolution accurate mass spectrometry. drugs, poisons HRAM GC-MS
 Using gas chromatography and mass spectrometry to determine 25-hydroxyvitamin D levels for clinical assessment of vitamin D deficiency. 25-hydroxyvitamin D GC-MS/MS

Multiplexing

Title Analyte Technique
 UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma antiretroviral drugs LC-MS/MS
 UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma immunosuppressant LC-MS/MS
 An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM). insulin, insulin analogs HRAM MS
 Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays. peptides Triple Quadrupole MS
 Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays. peptidase Triple Quadrupole MS
 Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications. proteins Triple Quadrupole MS

Paper spray

Title Analyte Technique
 Paper spray ionization mass spectrometry: recent advances and clinical applications. review HRAM MS and Triple Quadrupole MS
 Rapid analysis of fentanyls and other novel psychoactive substances in substance use disorder patient urine using paper spray mass spectrometry. fentanyls HRAM MS
 Paper Spray Ionization Coupled to High Resolution Tandem Mass Spectrometry for Comprehensive Urine Drug Testing in Comparison to Liquid Chromatography-Coupled Techniques after Urine Precipitation or Dried Urine Spot Workup. drugs of abuse HRAM MS

ICP-MS

Title Analyte Technique
 Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection HER2 ICP-MS
 A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS trace elements ICP-MS
 Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid. iodine ICP-MS
 Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection. pepsinogen, element tagged immunoassay ICP-MS
 Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry. copper, sulfur, phosphorus, iron ICP-MS
 Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population. iodine ICP-MS
 High-precision isotopic analysis of serum and whole blood Cu, Fe and Zn to assess possible homeostasis alterations due to bariatric surgery. copper ICP-MS
 Blood and plasma titanium levels associated with well-functioning hip implants. titanium ICP-MS
 Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection. HER2 ICP-MS
 Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases. trace elements ICP-MS
 Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. cadmium, selenium ICP-MS
 Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing. iodine ICP-MS
 Whole blood selenium determination by inductively coupled plasma mass spectrometry. selenium ICP-MS
 Quantification of multiple elements in dried blood spot samples. trace elements ICP-MS
 Urinary chromium is associated with changes in leukocyte miRNA expression in obese subjects. chromium ICP-MS
 Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children. trace elements ICP-MS
 Determination of Thirteen Trace and Toxic Elements in Urine Using Inductively Coupled Mass Spectrometry. trace elements ICP-MS

Ion chromatography

Title Analyte Technique
 Purity determination of synthetic glucagon using a mass balance approach glucagon and impurtieies HRAM IC-MS
 Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry. anionic metabolites HRAM IC-MS
 An improved reference method for serum cations measurement by ion chromatography. cations IC
 Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic Acids. organic acids IC-MS/MS

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