| Toxicology, Quantitative | Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry. | synthetic cathinones, metabolites | HRAM MS |
| Toxicology, Quantitative | Buprenorphine detection in urine using liquid chromatography-high-resolution mass spectrometry: comparison with cloned enzyme donor immunoassay (ThermoFisher) and homogeneous enzyme immunoassay (immunalysis). | buprenorphine | HRAM MS |
| Toxicology, Quantitative | Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse. | cytochrome P450 | HRAM MS |
| Toxicology, Quantitative | Analysis of drugs of abuse by online SPE-LC high resolution mass spectrometry: communal assessment of consumption. | drugs of abuse | HRAM MS |
| Toxicology, Quantitative | The use of turbulent flow chromatography for rapid, on-line analysis of tryptic digests. | tryptic drugs | HRAM MS |
| Toxicology, Quantitative | Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking. | heterocyclic amines 2-amino-9H-pyrido[2,3-b]indole, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, e-cigarette | Triple Quadrupole MS |
| Toxicology, Quantitative | Rapid determination of nine barbiturates in human whole blood by liquid chromatography-tandem mass spectrometry. | barbiturates | Triple Quadrupole MS |
| Toxicology, Quantitative | Liquid chromatography-high resolution-tandem mass spectrometry using Orbitrap technology for comprehensive screening to detect drugs and their metabolites in blood plasma. | drugs, drug metabolites | HRAM MS |
| Toxicology, Quantitative | Use of LC-HRMS in full scan-XIC mode for multi-analyte urine drug testing - a step towards a 'black-box' solution? | psychoactive substances, NPS | HRAM MS |
| Toxicology, Quantitative | High-Throughput Screening and Quantitation of Target Compounds in Biofluids by Coated BladeSpray-Mass Spectrometry. | anabolics, stimulants, diuretics, narcotics | Triple Quadrupole MS |
| Toxicology, Quantitative | A liquid chromatography and tandem mass spectrometry method to determine 28 non-volatiledrugs of abuse in exhaled breath. | drugs, volatile drugs | Triple Quadrupole MS |
| Toxicology, Quantitative | Dilute-and-shoot coupled to nanoflow liquid chromatography high resolution mass spectrometry for the determination of drugs of abuse and sport drugs in human urine. | DOA, drugs of abuse | HRAM MS |
| Toxicology, Quantitative | Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice. | e-cigarette | Triple Quadrupole MS |
| Toxicology, Quantitative | Quantitative analysis of dextran in rat plasma using Q-Orbitrap mass spectrometry based on all ion fragmentation strategy. | dextran | HRAM MS |
| Toxicology, Quantitative | A UHPLC-MS/MS method for the quantification of Δ9-tetrahydrocannabinol and cannabidiol in decoctions and in plasma samples for therapeutic monitoring of medical cannabis. | THC, tetrahydrocannabinol | Triple Quadrupole MS |
| Toxicology, Quantitative | Adsorption of tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl)-1-butanone from aqueous solution with graphene aerogel | nitrosamine; tobacco-specific | Triple Quadrupole MS |
| Toxicology, Quantitative | Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry. | oxytocin, fatty acyl, lipids | HRAM MS |
| Toxicology, Quantitative | A liquid chromatography-tandem mass spectrometry platform for the routine therapeutic drug monitoring of 14 antibiotics: Application to critically ill pediatric patients | antibiotics | Triple quadrupole MS |
| Toxicology, Quantitative | Driving Under the Influence of Drugs: A Single Parallel Monitoring-Based Quantification Approach on Whole Blood | 22 DOA | HRAM MS |
| Toxicology, Quantitative | Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam | flubromazolam, designer benzodiazepine | HRAM MS |
| Toxicology, Quantitative | Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy | ketamine, midazolame, dehydronorketamine, norgetamine, metabolites | HRAM MS |
| Toxicology, Quantitative | Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process | antipsychotic | HRAM MS |
| Toxicology, Quantitative | Analysis for Alpha-Pyrrolidinovalerophenone and Its 2-Oxo-PVP Metabolite in Plasma by Liquid Chromatography-Tandem Mass Spectrometry | Alpha-pyrrolidinovalerophenone (alpha-PVP) | Triple Quadrupole MS |
| Toxicology, Quantitative | Microfluidic filter device coupled mass spectrometry for rapid bacterial antimicrobial resistance analysis | antibiotics | Ion Trap MS |
| Toxicology, Quantitative | Drugs in bone: Detectability of substances of toxicological interest in different states of preservation | DOA | HRAM MS |
| Toxicology, Quantitative | Development and validation of a LC-HRMS method for the quantification of cannabinoids and their metabolites in human plasma | cannabinoids, cannabidiol, THC | HRAM MS |
| Toxicology, Quantitative | Development, validation, and application of a quantitative volumetric absorptive microsampling–based method in finger prick blood by means of LC-HRMS/MS applicable for adherence monitoring of antipsychotics | antipsychotics | HRAM MS |
| Toxicology, Quantitative | Development, Validation, and Comparison of Two Mass Spectrometry Methods (LC-MS/HRMS and LC-MS/MS) for the Quantification of Rituximab in Human Plasma | antipsychotics | HRAM MS |
| Toxicology, Quantitative | Metabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high-resolution mass spectrometry | mephtetramine | HRAM MS |
| Toxicology, Quantitative | Method development for the identification of methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine and their main metabolites in blood and hair and forensic application | methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine | HRAM MS |
| Toxicology, Screening | Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular | drug screening | HRAM MS |
| Toxicology, Screening | Fully automated semi-quantitative toxicological screening in three biological matrices using turbulent flow chromatography/high resolution mass spectrometry. | drugs of abuse | HRAM MS |
| Toxicology, Screening | First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry. | PV8, pyrrolidinophenone, drugs, novel psychoactive substances, NPS | HRAM MS |
| Toxicology, Screening | LC-HR-MS/MS standard urine screening approach: Pros and cons of automated on-line extraction by turbulent flow chromatography versus dilute-and-shoot and comparison with established urine precipitation. | drugs, metabolites | HRAM MS |
| Toxicology, Screening | Comprehensive analysis by liquid chromatography Q-Orbitrap mass spectrometry: Fast screening of peptides and organic molecules. | peptides, organic compounds, DOA | HRAM MS |
| Toxicology, Screening | Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances. | psychoactive substances, NPS | HRAM MS |
| Toxicology, Screening | Automated analysis of dried urine spot (DUS) samples for toxicology screening. | DOA, drugs of abuse | Triple quadrupole MS |
| Toxicology, Screening | Characterization and tentative identification of new flunitrazepam metabolites in authentic human urine specimens using liquid chromatography-Q exactive-HF hybrid quadrupole-Orbitrap-mass spectrometry (LC-QE-HF-MS) | flunitrazepam | HRAM MS |
| Toxicology, Screening | Detecting drugs in dry bone: a pilot study of skeletal remains with a post-mortem interval over 23 years | drugs | HRAM GC-MS, HRAM MS |
| Toxicology, Screening | Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples | fentanyl analogs | Triple quadrupole MS |
| Toxicology, Screening | Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances | DOA, drugs of abuse | HRAM MS |
| Toxicology, Screening | Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry | flubromazolam, designer benzodiazepine | HRAM MS |
| Toxicology, Screening | LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples. | cathinone analogues, microsampling | HRAM MS |
| Toxicology, Screening | Liquid chromatography-high resolution mass spectrometry for broad-spectrum drug screening of dried blood spot as microsampling procedure | drugs of abuse, dried blood spot | HRAM MS |
| Toxicology, Screening | Detection of synthetic cannabinoid adulteration in the unregulated drug supply in three Canadian settings | synthetic cannabinoid adulteration | HRAM MS |
| Toxicology, Screening | Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers | DOA | HRAM MS |
| Toxicology, Screening | Development and validation of a method for quantification of human insulin and its synthetic analogues in plasma and post-mortem sera by LC-MS/HRMS | insulin | HRAM MS |
| Translational research | Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): a novel glycan-relative quantification strategy. | INLIGHT, isotope glycan hydrazide tags | HRAM MS |
| Translational research | Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometer. | SILAC, mTRAQ, phosphoproteoomics | HRAM MS |
| Translational research | Overcoming challenges and opening new opportunities in glycoproteomics. | glycoproteomics | HRAM MS |
| Translational research | Collagen peptides in urine: a new promising biomarker for the detection of colorectal liver metastases. | peptides | HRAM MS |
| Translational research | A direct-infusion- and HPLC-ESI-Orbitrap-MS approach for the characterization of intact PEGylated proteins. | PEGylated protein | HRAM MS |
| Translational research | Stable, reproducible, and automated capillary zone electrophoresis-tandem mass spectrometry system with an electrokinetically pumped sheath-flow nanospray interface. | proteins | HRAM MS |
| Translational research | Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis. | proteome | HRAM MS |
| Translational research | Deep proteomic profiling of human carotid atherosclerotic plaques using multidimensional LC-MS/MS. | proteome | HRAM MS |
| Translational research | Glycoform analysis of recombinant and human immunodeficiency virus envelope protein gp120 via higher energy collisional dissociation and spectral-aligning strategy. | glycoform, protein gp120 | HRAM MS |
| Translational research | Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer. | proteome | HRAM MS |
| Translational research | Using In-Solution Digestion, Peptide Fractionation, and a HRAM MS Mass Spectrometer to Analyze the Proteome of Clathrin-Coated Vesicles | proteome of clathrin-coated vesicles | HRAM MS |
| Translational research | Urine sample preparation in 96-well filter plates to characterize inflammatory and infectious diseases of the urinary tract. | proteins | HRAM MS |
| Translational research | Comparative reevaluation of FASP and enhanced FASP methods by LC-MS/MS. | proteins | HRAM MS |
| Translational research | A Double-Barrel Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) System to Quantify 96 Interactomes per Day. | proteome | HRAM MS |
| Translational research | Quantification of cytokines secreted by primary human cells using multiple reaction monitoring: evaluation of analytical parameters. | cytokines | HRAM MS |
| Translational research | A novel and sensitive assay for heme oxygenase activity | protein | Triple Quadrupole MS |
| Translational research | Solid-phase extraction of small biologically active peptides on cartridges and microelution 96-well plates from human urine | peptides | Triple Quadrupole MS |
| Translational research | Quantitative Site-Specific Phosphoproteomics of Trichoderma reesei Signaling Pathways upon Induction of Hydrolytic Enzyme Production. | phosphoproteomics | HRAM MS |
| Translational research | Implementation of Ultraviolet Photodissociation on a Benchtop HRAM MS Mass Spectrometer and Its Application to Phosphoproteomics. | phosphoproteomics | HRAM MS |
| Translational research | Selecting Optimal Peptides for Targeted Proteomic Experiments in Human Plasma Using In Vitro Synthesized Proteins as Analytical Standards. | peptides | Triple Quadrupole MS |
| Translational research | Constructing Proteome Reference Map of the Porcine Jejunal Cell Line (IPEC-J2) by Label-Free Mass Spectrometry. | proteome | HRAM MS |
| Translational research | Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays. | peptides | Triple Quadrupole MS |
| Translational research | Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays. | peptidase, human kallikrein-related peptidase | HRAM MS, Triple Quadrupole MS |
| Translational research | Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion. | streptococci captures | HRAM MS, Triple Quadrupole MS |
| Translational research | Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System. | proteins | Triple Quadrupole MS |
| Translational research | Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis. | elF4G | Triple Quadrupole MS |
| Translational research | Longitudinal investigation of salivary proteomic profiles in the development of early childhood caries. | peptides | HRAM MS |
| Translational research | Exploring ECD on a Benchtop HRAM MS Orbitrap Mass Spectrometer. | bottom-up proteomics, ECD utility | HRAM MS |
| Translational research | Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach. | proteins, brain | Triple Quadrupole MS |
| Translational research | Ultra-High-Resolution Mass Spectrometry for Identification of Closely Related Dermatophytes with Different Clinical Predilections. | proteins, top-down, fungi | HRAM MS |
| Translational research | Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications. | proteins, brain | Triple Quadrupole MS |
| Translational research | Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry. | proteome | Triple Quadrupole MS |
| Translational research | Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry. | proteome | Triple Quadrupole MS |
| Translational research | Acute Proteomic Changes in the Lung after WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure. | proteome | HRAM MS |
| Translational research | iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy. | biomarkers, proteins | HRAM MS |
| Translational research | DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery | proteins, peptides | HRAM MS |
| Translational research | High-throughput, in-depth and estimated absolution quantification of plasma proteome using data-independent acquisition/ mass spectrometry ("HIAP-DIA") | protein | HRAM MS |
| Translational research | Integrating Serum Protein Electrophoresis with Mass Spectrometry, A New Workflow for M-Protein Detection and Quantification | M-protein | HRAM MS |
| Translational research | Large-scale targeted metabolomics method for metabolite profiling of human samples | metabolites | HRAM MS |
| Translational research | Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters | peptides | HRAM MS |
| Translational research | Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies | peptides | HRAM MS |
| Translational research | Vedolizumab quantitation using high-resolution accurate mass-mass spectrometry middle-up protein subunit: method validation | vedolizumab | HRAM MS |
| Translational research | Critical comparison of three MS-based approaches for quantitative proteomics analysis | peptides | HRAM MS |
| Translational research | Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis | lipids, PE, PC, LPE | HRAM MS |
| Translational research | Clinical Translation and Evaluation of a Handheld and Biocompatible Mass Spectrometry Probe for Surgical Use | metabolites, lipids | HRAM MS |
| Clinical research biomarkers | Matrix-assisted laser desorption/ionization for simultaneous quantitation of (acyl-)carnitines and organic acids in dried blood spots. | acylcarnitines, carnitines, organic acids | HRAM MS |
| Clinical research biomarkers | An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM). | insulin, insuline analogs | HRAM MS |
| Clinical research biomarkers | Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry. | anionic metabolites | HRAM MS |
| Clinical research biomarkers | Large-scale label-free comparative proteomics analysis of polo-like kinase 1 inhibition via the small-molecule inhibitor BI 6727 (Volasertib) in BRAF(V600E) mutant melanoma cells. | polo-like kinase 1, BI6727, Volasertib, BRAF, V600E | HRAM MS |
| Clinical research biomarkers | A strategy for sensitive, large scale quantitative metabolomics. | metabolomics | HRAM MS |
| Clinical research biomarkers | Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3. | NOX4, ITGA3 | HRAM MS |
| Clinical research biomarkers | Simultaneous quantification of Sphingolipids in small quantities of liver by LC-MS/MS | sphingolipids | Triple Quadrupole MS |
| Clinical research biomarkers | Underivatized oxysterols and nanoLC-ESI-MS: A mismatch. | oxysterols | HRAM MS, Triple Quadrupole MS |
| Clinical research biomarkers | Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry. | 25-hydroxy vitamin D | HRAM MS |
| Clinical research biomarkers | Detection and quantification of proteins in clinical samples using high resolution mass spectrometry. | protein, biomarker | HRAM MS |
| Clinical research biomarkers | High speed capillary zone electrophoresis-mass spectrometry via an electrokinetically pumped sheath flow interface for rapid analysis of amino acids and a protein digest. | amino acid, proteins | HRAM MS |
| Clinical research biomarkers | Targeted Metabolomic Analysis of Head and Neck Cancer Cells Using High Performance Ion Chromatography Coupled with a HRAM MS HF Mass Spectrometer. | targeted metabolomics | HRAM MS |
| Clinical research biomarkers | MS2PIP prediction server: compute and visualize MS2 peak intensity predictions for CID and HCD fragmentation. | prediction models for fragmentation | HRAM MS |
| Clinical research biomarkers | Analysis of Cell Metabolism Using LC-MS and Isotope Tracers. | metabolism | HRAM MS |
| Clinical research biomarkers | Measurement of Lung Phosphatidylcholines in Exhaled Breath Particles by a Convenient Collection Procedure. | phosphatidylcholines | Triple Quadrupole MS |
| Clinical research biomarkers | Metabolism of human insulin after subcutaneous administration: A possible means to uncover insulin misuse. | insulin, insulin metabolites | HRAM MS |
| Clinical research biomarkers | Histamine quantification in human plasma using high resolution accurate mass LC-MS technology. | histamine | HRAM MS |
| Clinical research biomarkers | Sensitive, Simple, and Robust Nano-Liquid Chromatography-Mass Spectrometry Method for Amyloid Protein Subtyping. | amyloid protein | HRAM MS |
| Clinical research biomarkers | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | oxysterols | HRAM MS |
| Clinical research biomarkers | In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant. | α-pyrrolidinopentiothiophenone | HRAM MS |
| Clinical research biomarkers | Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in AlzheimerDisease and Frontotemporal Lobar Degeneration. | visinin-like protein | Triple Quadrupole MS |
| Clinical research biomarkers | Development and Evaluation of a Parallel Reaction Monitoring Strategy for Large-Scale Targeted Metabolomics Quantification. | metabolites | HRAM MS |
| Clinical research biomarkers | Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics. | PEGylated protein | HRAM MS |
| Clinical research biomarkers | Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells. | protein, estrogen receptor | HRAM MS, Triple Quadrupole MS |
| Clinical research biomarkers | Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery. | thromboxane | Triple Quadrupole MS |
| Clinical research biomarkers | Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease. | APOE, apolipoprotein | Triple Quadrupole MS |
| Clinical research biomarkers | Associations between calcium-phosphate metabolism and coronary artery calcification; a cross sectional study of a middle-aged general population. | parathyroid hormone (PTH) and 25-hydroxyvitamin D | Triple Quadrupole MS |
| Clinical research biomarkers | Transfer of developmental neurotoxin β-N-methylamino-l-alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis. | BMAA, neurotoxin | Triple Quadrupole MS |
| Clinical research biomarkers | Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring | angiotensin II-regulated proteins | Triple Quadrupole MS |
| Clinical research biomarkers | Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. | carboxyl ester lipase (CEL) | Triple Quadrupole MS |
| Clinical research biomarkers | An analytical strategy to investigate Semen Strychni nephrotoxicity based on simultaneous HILIC-ESI-MS/MS detection of Semen Strychni alkaloids, tyrosine and tyramine in HEK 293t cell lysates. | semen strychini alkaloids, tyrosine, tyramine | HRAM MS |
| Clinical research biomarkers | Simultaneous Determination of Multiple Intracellular Primary Metabolites by Ultrahigh Performance Liquid Chromatography Coupled with a HRAM MS HF Mass Spectrometer. | primary metabolites | HRAM MS |
| Clinical research biomarkers | Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. | biomarkers, polar metabolites, lipids | HRAM MS |
| Clinical research biomarkers | Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus. | plasmalogen | Triple Quadrupole MS |
| Clinical research biomarkers | 25C‐NBOMe and 25I‐NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high‐resolution mass spectrometry | 25C-NBOMe, 25I-NBOMe | HRAM MS |
| Clinical research biomarkers | Determination of amino acids in colon cancer cells by using UHPLC-MS/MS and [U-13C5]-glutamine as the isotope tracer. | amino acids | Triple Quadrupole MS |
| Clinical research biomarkers | Identification and Characterization of Cardiac Troponin T Fragments in Serum of Patients Suffering from Acute Myocardial Infarction. | biomarker, cardiac troponin T | HRAM MS |
| Clinical research biomarkers | Identification and quantitation of phosphatidylethanols in oral fluid by liquid chromatography-tandem mass spectrometry. | phospatidylethanol | Triple Quadrupole MS |
| Clinical research biomarkers | A Nontargeted UHPLC-HRMS Metabolomics Pipeline for Metabolite Identification: Application to Cardiac Remote Ischemic Preconditioning. | biomarkers | HRAM MS |
| Clinical research biomarkers | Expanding the knowledge on dried blood spots and LC-MS-based protein analysis: two different sampling materials and six protein targets. | protein | HRAM MS, Triple Quadrupole MS |
| Clinical research biomarkers | Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure. | protein, biomarker | HRAM MS |
| Clinical research biomarkers | Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. | fructose 1,6-biphosphate, aldose mediate glucose | Triple Quadrupole MS |
| Clinical research biomarkers | Quantification of xanthine- and uric acid-related compounds in urine using a "dilute-and-shoot" technique coupling ultra-high-performance liquid chromatography and high-resolution Orbitrap mass spectrometry. | xanthine, uric acid | HRAM MS |
| Clinical research biomarkers | Holistic Lipidomics of the Human Gut Phenotype Using Validated Ultra-High-Performance Liquid Chromatography Coupled to Hybrid Orbitrap Mass Spectrometry. | fatty acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, sterols | HRAM MS |
| Clinical research biomarkers | Lower plasma choline levels are associated with sleepiness symptoms. | choline | Triple Quadrupole MS |
| Clinical research biomarkers | Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaMSites to Activation. | AMPK | Triple Quadrupole MS |
| Clinical research biomarkers | Easy, Fast, and Reproducible Quantification of Cholesterol and Other Lipids in Human Plasma by Combined High Resolution MSX and FTMS Analysis. | cholesterol, glycerolipids, sphingolipids, sterol esters | HRAM MS |
| Clinical research biomarkers | Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells. | peptides | Triple Quadrupole MS |
| Clinical research biomarkers | Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing. | amino acid, lipid | Triple Quadrupole MS |
| Clinical research biomarkers | Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry. | dinnutuximab | Triple Quadrupole MS |
| Clinical research biomarkers | N6-(2-Deoxy-d- erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5- N-(2-hydroxy-3-buten-1-yl)-formamidopyrimidine Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells. | nucleobase adducts | Triple Quadrupole MS |
| Clinical research biomarkers | Rapid detection and quantification of aminoglycoside phosphorylation products using direct‐infusion high‐resolution and ultra‐high‐performance liquid chromatography/mass spectrometry | aminoglycoside phosporylation products | HRAM MS |
| Clinical research biomarkers | Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression. | pentraxin receptor | Triple Quadrupole MS |
| Clinical research biomarkers | Total Fatty Acid Analysis of Human Blood Samples in One Minute by High-Resolution Mass Spectrometry. | fatty acids | HRAM MS |
| Clinical research biomarkers | Bioactive Lipids in Sputum of Older Adults with Asthma as Potential Markers of Disease Phenotypes | lipids | Triple Quadrupole MS |
| Clinical research biomarkers | How do cancer-sniffing dogs sort biological samples? Exploring case-control samples with non-targeted LC-Orbitrap, GC-MS, and immunochemistry methods. | biomarkers, polar metabolites, lipids | HRAM MS |
| Clinical research biomarkers | A validated multi-matrix platform for metabolomic fingerprinting of human urine, feces and plasma using ultra-high performance liquid-chromatography coupled to hybrid orbitrap high-resolution mass spectrometry. | biomarkers | HRAM MS |
| Clinical research biomarkers | Rapid analysis of pyridinoline and deoxypyridinoline in biological samples by liquid chromatography-mass spectrometry and silica hydride column. | pyridinoline, deoxypyridinoline | HRAM MS |
| Clinical research biomarkers | Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer. | lipids | HRAM MS |
| Clinical research biomarkers | Plasma free metanephrines for diagnosis of neuroblastoma patients. | metanephrines, plasma free metanephrines | Triple Quadrupole MS |
| Clinical research biomarkers | Strain-Level Differentiation of Bacteria by Paper Spray Ionization Mass Spectrometry. | bacteria | HRAM MS |
| Clinical research biomarkers | Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome. | untargeted, amino acids, sphingolipids, fatty acids | HRAM MS, Triple Quadrupole MS |
| Clinical research biomarkers | An Integrated Approach to Characterize Intestinal Metabolites of Four Phenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant Activity Evaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay. | biomarkers | HRAM MS |
| Clinical research biomarkers | Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis. | biomarkers | HRAM MS |
| Clinical research biomarkers | Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile. | proteomes, lipids | HRAM MS |
| Clinical research biomarkers | Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass Spectrometry | amatoxins | HRAM MS |
| Clinical research biomarkers | Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry. | copper, ceruloplasmin | ICP-MS |
| Clinical research biomarkers | Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species | pollen allergen | HRAM MS |
| Clinical research biomarkers | Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population. | iodine | ICP-MS |
| Clinical research biomarkers | Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine | immunosuppressants | Clinical Analyzer |
| Clinical research biomarkers | High-precision isotopic analysis of serum and whole blood Cu, Fe and Zn to assess possible homeostasis alterations due to bariatric surgery. | copper, iron, zinc | ICP-MS |
| Clinical research biomarkers | LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients | spingolipids | HRAM MS |
| Clinical research biomarkers | Metabolism Study of N-Methyl 2-amino Indane (NM2AI) and Determination of Metabolites in Biological Samples by LC-HRMS | N-methyl-2-aminoindane | HRAM MS |
| Clinical research biomarkers | Purity determination of synthetic glucagon using a mass balance approach | glucagon | HRAM MS |
| Clinical research biomarkers | Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection. | pepsinogen, element tagged immunoassay | ICP-MS |
| Clinical research biomarkers | Simultaneous analysis of monosaccharides using ultra high performance liquid chromatography-high resolution mass spectrometry without derivatization for validation of certified reference materials | D-Ribose, L-Arabinose, D-Xylose, D-Fructose, D-Mannose, D-Galactose and D-Glucose | HRAM MS |
| Clinical research biomarkers | Preliminary study procedure for detection of polyamines in plasma samples as a potential diagnostic tool in prostate cancer | polyamines | HRAM MS |
| Clinical research biomarkers | High-sensitivity quantification of acetylcholine and choline in human cerebrospinal fluid with a validated LC-MS/MS method | choline, acetylcholine | Triple Quadrupole MS |
| Clinical research biomarkers | Quantitative analysis of tryptophan and its metabolites in urine by ultra performance liquid chromatography-tandem mass spectrometry | tryptophan | Triple Quadrupole MS |
| Disease and disorders | A multipronged deep omics-based investigation of COVID-19 plasma samples identifies key molecular networks of disease severity progression | COVID-19 | HRAM MS |
| Disease and disorders | Global N‐glycan site occupancy of HIV‐1 gp120 by metabolic engineering and high‐resolution intact mass spectrometry. | HIV | HRAM MS |
| Disease and disorders | A novel function of IMPA2, plays a tumor-promoting role in cervical cancer | cancer | HRAM MS |
| Disease and disorders | A preliminary study procedure for detection of polyamines in plasma samples as a potential diagnostic tool in prostate cancer | polyamines | HRAM MS |
| Disease and disorders | A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity | COVID-19 | HRAM MS |
| Disease and disorders | Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses | COVID-19 | HRAM MS |
| Disease and disorders | Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage. | COVID-19 | HRAM MS |
| Disease and disorders | Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome | Zika | HRAM MS |
| Disease and disorders | Cerebrospinal Fluid of Preeclamptic and Normotensive Pregnant Women Compared to Nonpregnant Women Analyzed with Mass Spectrometry | protein | HRAM MS |
| Disease and disorders | Detection of Head and Neck Cancer Based on Longitudinal Changes in Serum Protein Abundance A | cancer | HRAM MS |
| Disease and disorders | Development and fit-for-purpose verification of an LC-MS method for quantitation of hemagglutinin and neuraminidase proteins in influenza virus-like particle vaccine candidates | influenza | HRAM MS |
| Disease and disorders | Development of mass spectrometry-based targeted assay for direct detection of novel SARS-CoV-2 coronavirus from clinical specimens | COVID-19 | HRAM MS |
| Disease and disorders | Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesis | disease pathogenesis | HRAM MS |
| Disease and disorders | Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts | COVID-19 | HRAM MS |
| Disease and disorders | Evidence of Structural protein damage and membrane lipid remodeling in Red Blood Cells from COVID-19 patients | COVID-19 | HRAM MS |
| Disease and disorders | Exosomes in plasma for protein based cancer biomarkers: A clinical research tool using UHPLC-MS | exosomes | HRAM MS |
| Disease and disorders | High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans | tuberculosis | HRAM MS |
| Disease and disorders | Identication of novel salivary candidate protein biomarkers for tuberculosis diagnosis | tuberculosis | HRAM MS |
| Disease and disorders | Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics | COVID-19 | HRAM MS |
| Disease and disorders | Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children | tuberculosis | HRAM MS |
| Disease and disorders | Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected cases | exosomes, plasma, amnionic fluid | HRAM MS |
| Disease and disorders | LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy | cardiac disease | HRAM MS |
| Disease and disorders | Mass spectrometry-based absolute quantification of amyloid proteins in pathology tissue specimens: Merits and limitations | amyloid protein | HRAM MS, triple quadrupole MS |
| Disease and disorders | Mechanism of succinate efflux upon reperfusion of the ischaemic heart | cardiac disease | HRAM MS |
| Disease and disorders | Nanomedicine therapies modulating Macrophage Dysfunction: a potential strategy to attenuate Cytokine Storms in severe infections | nanomedicine | HRAM MS |
| Disease and disorders | Proteomics as a tool for live attenuated influenza vaccine characterisation | influenza | HRAM MS |
| Disease and disorders | Proteomics of Select Neglected Tropical Diseases | Dengue | HRAM MS |
| Disease and disorders | Proteotyping SARS-CoV‑2 Virus from Nasopharyngeal Swabs: A Proof-of-Concept Focused on a 3 Min Mass Spectrometry Window | COVID-19 | HRAM MS |
| Disease and disorders | Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation | protein | HRAM MS |
| Disease and disorders | Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. | COVID-19 | HRAM MS |
| Disease and disorders | Rapid quantification of insulin degludec by immunopurification combined with liquid chromatography high-resolution mass spectrometry | insulin degludec | HRAM MS |
| Disease and disorders | Role of Multiomics Data to Understand Host–Pathogen Interactions in COVID-19 Pathogenesis | COVID-19 | HRAM MS |
| Disease and disorders | Shortlisting SARS-CoV-2 Peptides for Targeted Studies from Experimental Data-Dependent Acquisition Tandem Mass Spectrometry Data | COVID-19 | HRAM MS |
| Disease and disorders | Simultaneous quantification of major capsid protein of human papillomavirus 16 and human papillomavirus 18 in multivalent human papillomavirus vaccines by liquid chromatography-tandem mass spectrometry | HPV | HRAM MS |
| Disease and disorders | Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS analysis | COVID-19 | HRAM MS |
| Disease and disorders | Update on Proteomic approaches to uncovering virus-induced protein alterations and virus –host protein interactions during the progression of viral infection | H1N1 | HRAM MS |
| Disease and disorders | Zika Infection Disrupts Proteins Involved in the Neurosensory System | Zika | HRAM MS |
| Disease and disorders | Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis | PGLYRP | HRAM MS |
| Disease and disorders | Protocols for Preparation and Mass Spectrometry Analysis of Clinical Urine Samples to Identify Candidate Biomarkers of Schistosoma-Associated Bladder Cancer | proteins, peptides | HRAM MS |
| Disease and disorders | Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's disease | peptides | HRAM MS |
| Disease and disorders | Quantitative proteomic analysis to identify differentially expressed proteins in patients with epilepsy | proteome | HRAM MS |
| Disease and disorders | Serum proteome signature to predict mortality in severe COVID-19 patients | SARS CoV-2 | HRAM MS |
| Disease and disorders | Determination of amanita peptide toxins in human urine by TurboFlow online clean-up-liquid chromatography-tandem mass spectrometry | amantia peptide toxins, Turboflow | HRAM MS |
| Disease and disorders | Mass spectrometry-based targeted assay for detection of SARS-CoV-2 antigen from clinical specimens | SARS CoV-2 | HRAM MS |
| Disease and disorders | Accurate Identification of Closely Related Mycobacterium tuberculosis Complex Species by High Resolution Tandem Mass Spectrometry | proteoforms | HRAM MS |
| Disease and disorders | Primary angle closure glaucoma is characterized by altered extracellular matrix homeostasis in the iris | peptides | HRAM MS |
| Endocrinology | An optimized method for neurotransmitters and their metabolites analysis in mouse hypothalamus by high performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry. | neurotransmitters, hypothalamus, neurotransmitter metabolites | HRAM MS |
| Endocrinology | Simultaneous quantification of neuroactive dopamine serotonin and kynurenine pathway metabolites in gender-specific youth urine by ultra performance liquid chromatography tandem high resolution mass spectrometry. | dopamine, serotonin, kynurenine pathway metabolites | HRAM MS |
| Endocrinology | Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester. | resveratrol effects on steroidogenesis | Triple Quadrupole MS |
| Endocrinology | Quantification of steroid hormones in human serum by liquid chromatography-high resolution tandem mass spectrometry. | steroid hormones | HRAM MS |
| Endocrinology | Comparative limitations and benefits of liquid chromatography - mass spectrometry techniques for analysis of sex steroids in tears. | steroids | HRAM MS |
| Endocrinology | A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids. | progestins, steroids | HRAM MS |
| Endocrinology | Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometry system, the Thermo Scientific Cascadion SM Clinical Analyzer with the Cascadion 25-hydroxy vitamin D assay in a routine clinical laboratory. | 25-hydroxy vitamin D | Clinical Analyzer |
| Endocrinology | Simultaneous quantification of fat-soluble vitamins A, 25-hydroxylvitamin D and vitamin E in plasma from children using liquid chromatography coupled to Orbitrap mass spectrometry | Vitamin A, D, E | HRAM MS |
| Therapeutic drug monitoring | Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS assay. | teicoplanin | HRAM MS |
| Therapeutic drug monitoring | The development and validation of a method using high-resolution mass spectrometry (HRMS) for the qualitative detection of antiretroviral agents in human blood. | antiretroviral drugs, HIV drugs | HRAM MS |
| Therapeutic drug monitoring | Assessment of tandem mass spectrometry and high-resolution mass spectrometry for the analysis of bupivacaine in plasma. | bupivacaine | Triple Quadrupole MS, HRAM MS |
| Therapeutic drug monitoring | A high-resolution accurate mass (HR/AM) approach to identification, profiling and characterization of in vitro nefazodone metabolites using a hybrid quadrupole Orbitrap (Q-Exactive). | nefazodone metabolites | HRAM MS |
| Therapeutic drug monitoring | Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry. | acetomenophen, alicylic acid | HRAM MS |
| Therapeutic drug monitoring | Quantification of active infliximab in human serum with liquid chromatography–tandem mass spectrometry using a tumor necrosis factor alpha -based pre-analytical sample purification and a stable isotopic labeled infliximab bio-similar as internal standard: | infliximab | Triple Quadrupole MS |
| Therapeutic drug monitoring | Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide. | phenobarbital, phenytoin, carbamazepine | HRAM MS |
| Therapeutic drug monitoring | Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. | drugs, antihypertensive | HRAM MS |
| Therapeutic drug monitoring | Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices. | efavirenz | Triple Quadrupole MS |
| Therapeutic drug monitoring | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | tacrolimus, immunosuppressant | Triple Quadrupole MS |
| Therapeutic drug monitoring | Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment. | trastuzumab | Triple Quadrupole MS |
| Therapeutic drug monitoring | Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. | tacrolimus, sirolumus, everolimus, cyclosporin A, mycophenolic acid | Triple Quadrupole MS |
| Therapeutic drug monitoring | Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry. | voriconazole | Triple Quadrupole MS |
| Therapeutic drug monitoring | LC-MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs. | Fab-bound colchicine, Fab fragments | Triple Quadrupole MS |
| Therapeutic drug monitoring | Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry. | voriconazole | Triple Quadrupole MS |
| Therapeutic drug monitoring | Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Qexactive high-resolution benchtop quadrupole orbitrap mass spectrometer. | larotaxel | HRAM MS |
| Therapeutic drug monitoring | Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry. | benzodiazepines flubromazolam, pyrazolam | HRAM MS |
| Therapeutic drug monitoring | Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). | ISD, immunosuppressive drugs | Triple Quadrupole MS |
| Therapeutic drug monitoring | Development and validation of a liquid chromatography/tandem mass spectrometry method for determination of caspofungin in dried blood spots. | capsofungin | Triple Quadrupole MS |
| Therapeutic drug monitoring | Development and validation of a targeted affinity-enrichment and LC-MS/MS proteomics approach for the therapeutic monitoring of adalimumab. | adalimumab | HRAM MS |
| Therapeutic drug monitoring | An LC-MS/MS method for quantification of daptomycin in dried blood spot: Application to a pharmacokinetics study in critically ill patients | daptomycin | Triple Quadrupole MS |
| Therapeutic drug monitoring | Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometry | antifungals | PaperSpray Triple quadrupole MS |
| Therapeutic drug monitoring | Validation of an HPLC-MS/MS Method for the Determination of Plasma Ticagrelor and its Active Metabolite Useful for Research and Clinical Practice | Ticagrelor, Ticagrelor metabolite | Triple Quadrupole MS |
| Therapeutic drug monitoring | Validation of a novel UPLC-HRMS method for human whole-blood cyclosporine and comparison with a CMIA immunoassay | immunosuppressants | HRAM MS |
| Therapeutic drug monitoring | Analysis of Pembrolizumab in Human Plasma by LC-MS/HRMS. Method Validation and Comparison with Elisa | Pembrolizumab | HRAM MS |
| Orthogonal techniques, Gas chromatography | Development of a HS-SPME/GC–MS method for the analysis of volatile organic compounds from fabrics for forensic reconstruction applications | VOCs for forensic use | HRAM GC-MS |
| Orthogonal techniques, Gas chromatography | Non-targeted acquisition strategy for screening doping compounds based on GC-EI-hybrid quadrupole-Orbitrap mass spectrometry: focus on exogenous anabolic steroids | anabolic steroids | HRAM GC-MS |
| Orthogonal techniques, Gas chromatography | Development of a high-throughput screening analysis for 288 drugs and poisons in human blood using Orbitrap technology with gas chromatography-high resolution accurate mass spectrometry. | drugs, poisons | HRAM GC-MS |
| Orthogonal techniques, Gas chromatography | Using gas chromatography and mass spectrometry to determine 25-hydroxyvitamin D levels for clinical assessment of vitamin D deficiency. | 25-hydroxyvitamin D | GC-MS/MS |
| Orthogonal techniques, Multiplexing | UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma | antiretroviral drugs | LC-MS/MS |
| Orthogonal techniques, Multiplexing | UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma | immunosuppressant | LC-MS/MS |
| Orthogonal techniques, Multiplexing | An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM). | insulin, insulin analogs | HRAM MS |
| Orthogonal techniques, Multiplexing | Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays. | peptides | Triple Quadrupole MS |
| Orthogonal techniques, Multiplexing | Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays. | peptidase | Triple Quadrupole MS |
| Orthogonal techniques, Multiplexing | Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications. | proteins | Triple Quadrupole MS |
| Orthogonal techniques, Paper spray | Paper spray ionization mass spectrometry: recent advances and clinical applications. | review | HRAM MS and Triple Quadrupole MS |
| Orthogonal techniques, Paper spray | Rapid analysis of fentanyls and other novel psychoactive substances in substance use disorder patient urine using paper spray mass spectrometry. | fentanyls | HRAM MS |
| Orthogonal techniques, Paper spray | Paper Spray Ionization Coupled to High Resolution Tandem Mass Spectrometry for Comprehensive Urine Drug Testing in Comparison to Liquid Chromatography-Coupled Techniques after Urine Precipitation or Dried Urine Spot Workup. | drugs of abuse | HRAM MS |
| Orthogonal techniques, ICP-MS | Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection | HER2 | ICP-MS |
| Orthogonal techniques, ICP-MS | A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS | trace elements | ICP-MS |
| Orthogonal techniques, ICP-MS | Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid. | iodine | ICP-MS |
| Orthogonal techniques, ICP-MS | Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection. | pepsinogen, element tagged immunoassay | ICP-MS |
| Orthogonal techniques, ICP-MS | Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry. | copper, sulfur, phosphorus, iron | ICP-MS |
| Orthogonal techniques, ICP-MS | Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population. | iodine | ICP-MS |
| Orthogonal techniques, ICP-MS | High-precision isotopic analysis of serum and whole blood Cu, Fe and Zn to assess possible homeostasis alterations due to bariatric surgery. | copper | ICP-MS |
| Orthogonal techniques, ICP-MS | Blood and plasma titanium levels associated with well-functioning hip implants. | titanium | ICP-MS |
| Orthogonal techniques, ICP-MS | Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection. | HER2 | ICP-MS |
| Orthogonal techniques, ICP-MS | Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases. | trace elements | ICP-MS |
| Orthogonal techniques, ICP-MS | Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. | cadmium, selenium | ICP-MS |
| Orthogonal techniques, ICP-MS | Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing. | iodine | ICP-MS |
| Orthogonal techniques, ICP-MS | Whole blood selenium determination by inductively coupled plasma mass spectrometry. | selenium | ICP-MS |
| Orthogonal techniques, ICP-MS | Quantification of multiple elements in dried blood spot samples. | trace elements | ICP-MS |
| Orthogonal techniques, ICP-MS | Urinary chromium is associated with changes in leukocyte miRNA expression in obese subjects. | chromium | ICP-MS |
| Orthogonal techniques, ICP-MS | Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children. | trace elements | ICP-MS |
| Orthogonal techniques, ICP-MS | Determination of Thirteen Trace and Toxic Elements in Urine Using Inductively Coupled Mass Spectrometry. | trace elements | ICP-MS |
| Orthogonal techniques, ICP-MS | Evaluation of an Element-Tagged Duplex Immunoassay Coupled with Inductively Coupled Plasma Mass Spectrometry Detection: A Further Study for the Application of the New Assay in Clinical Laboratory | CEA, AFP, α-fetoprotein | ICP-MS |
| Orthogonal techniques, ICP-MS | Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid. | iodine | ICP-MS |
| Orthogonal techniques, Ion chromatography | Purity determination of synthetic glucagon using a mass balance approach | glucagon and impurtieies | HRAM IC-MS |
| Orthogonal techniques, Ion chromatography | Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry. | anionic metabolites | HRAM IC-MS |
| Orthogonal techniques, Ion chromatography | An improved reference method for serum cations measurement by ion chromatography. | cations | IC |
| Orthogonal techniques, Ion chromatography | Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic Acids. | organic acids | IC-MS/MS |
| Orthogonal techniques, Dried matrix spots | A novel LC-MS/MS assay for vitamin B 1, B 2 and B 6 determination in dried blood spots and its application in children | vitamin B1, B2, B6, dried blood spot | HRAM MS |
| Orthogonal techniques, Dried matrix spots | Analysis of cyclosporin A in dried blood spots using liquid chromatography tandem mass spectrometry | cyclosporin A, dried blood spot | HRAM MS |
| Orthogonal techniques, Dried matrix spots | Automated Analysis of Dried Urine Spot (DUS) Samples for Toxicology Screening | drugs of abuse, dried urine spot | HRAM MS |
| Orthogonal techniques, Dried matrix spots | State of Science in Dried Blood Spots | dried blood spots | HRAM MS |
| Orthogonal techniques, Dried matrix spots | Feasibility of Patient-Centric Remote Dried Blood Sampling: The Prediction, Risk, and Evaluation of Major Adverse Cardiac Events (PRE-MACE) Study | cardiac disease, dried blood spot | HRAM MS |
| Orthogonal techniques, Dried matrix spots | Power of Orbitrap‐based LC‐high resolution‐MS/MS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on‐spot cleavage in comparison to established LC–MSn or GC–MS procedures | drugs of abuse, dried urine spot | HRAM MS |
| Orthogonal techniques, Quantitative | New quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry | etizolam, fentanyl | Triple Quadrupole MS |
