Research equipment grant writing and technical resources

Whether you are new to cryo-electron microscopy (cryo-EM) or have years of experience with this technology, securing funding can be demanding, time-consuming, and stressful. Our team is here to help!


This funding support center contains several resources, including:

  • Proposal writing tools
  • Potential funding opportunities
  • Available financial services
  • Technical content, data sheets, and guides
Cryo-EM grant proposal and funding resource center

Some common funding challenges include:

  • Identifying the right grant and determining eligibility
  • Finding the right collaborators
  • Getting preliminary data in time for submission; setting up demos with vendors
  • Writing and story telling
  • Obtaining short and long-term institutional support
  • Acquiring a copy of a similar, successful proposal

Our technical experts can support you every step of the way:

  • Helping you gather the right information to submit a well-supported and accurate application
  • Getting the preliminary data and rationale for your proposal
  • Providing information about financing and leasing solutions
  • Discussing ideal workflow solutions for your analytical needs
  • And much more

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Cryo-electron microscopes

Find the right Thermo Scientific electron microscope for your research

Our dedicated customer success managers are your scientific partners. They can provide recommendations on the best instrumentation for your research as well as laboratory organization support, from sample preparation to electron microscopy and IT infrastructure. Explore our guidance for planning a cryo-EM laboratory for more information.

 VitrobotTalos L120C TEMTalos F200C TEMTundra Cryo-TEMGlacios 2 Cryo-TEMKrios G4 Cryo-TEM
Vitrobot System
Talos L120C TEM
Talos F200C TEM
Tundra Cryo-TEM
Glacios 2 Cryo-TEM
Krios G4 Cryo-TEM
Ideal Use or Applications
  • Sample prep
  • Vitrification
  • Room temperature EM
  • Pathology
  • Cell biology
  • Negative staining
  • Limited Cryo-EM screening
  • Room temperature EM
  • Pathology
  • Cell biology
  • Negative staining
  • Limited cryo-EM screening
  • Limited tomography
  • Sample optimization
  • Biochemistry optimization
  • Structure determination
  • 100 kV single particle analysis (SPA)
  • Structure determination
  • 200 kV SPA
  • Cryo-tomography
  • MicroED
  • Energy filter compatible
  • Structure determination 
  • 300KV SPA
  • Cryo-tomography
  • MicroED
  • Energy filter compatible
  • Highest resolution 
Key Benefits

Sample vitrification for optimal cryo-EM analysis

Ease-of-use, with multi-functional flexible applications

Ease-of-use, with multi-functional flexible applications

Cryo-EM within your reach: ease of use, with AI-guided automation

Routine, high- resolution SPA, with high throughput and productivity

Highest resolution SPA and tomography, with highest throughput and productivity

User Experience Level

All users

New users to experts

New users to experts

New to moderately experienced users

Moderately experienced to experts

Moderately experienced to experts

Cost to Get Started 






Price Per Structure 






Product DatasheetsVitrobotTalos L120CTalos F200CTundra Cryo-TEMGlacios 2 Cryo-TEMKrios G4 Cryo-TEM


Cryo-EM grant proposal and writing resources

Whether you are new to grant writing or have years of experience, securing funding can be demanding, time-consuming, and stressful. Not all funding opportunities are created equal, but successful grant applications have much in common. Watch our on-demand webinars for some proven grant writing strategies.


This on-demand webinar given by Dr. Christopher Dant discusses proven strategies used in the well-known Research (R01) grant application that can support your application for the NIH High-End Instrumentation (HEI) Grant Program (S10).

Watch an on-demand Q&A session about grant writing featuring Dr. Christopher Dant and Thermo Fisher Scientific Cryo-EM experts.


Potential funding opportunities for high-end instrumentation

Public and private grants are an ideal way to seek funding for the latest cryo-EM technology. This table presents some of the typical and lesser-known sources of funding.


DateGrant NameDivisionRange
Proposals Accepted Anytime   
RollingInfrastructure Innovation for Biological Research (Innovation)NSF20 to 40 Awards in a pool of $18 - $20M*
 Mid-scale Research Infrastructure-1 (Mid-scale RI-1)NSF$6M - $20M
 Major Research Instrumentation Program: (MRI) - Track 1NSF$100K - $1M
 Major Research Instrumentation Program: (MRI) - Track 2NSF$1M - $4M
 National Centers for Biomedical Imaging and BioengineeringNIH$500K - $750K
 Mid-scale Research Infrastructure-2 (Mid-scale RI-2)NSF$20M - $100M
 National Centers for Biomedical Imaging and BioengineeringNIH$500K - $750K
 Defense University Research Instrumentation Program (DURIP)DoD$50K - $1.5M
 The Guenther Foundation - California onlyPrivateOpen
 S10 - Shared Instrumentation Grant (SIG) ProgramNIH$50K - $600K
 S10 - High-End Instrumentation (HEI) Grant ProgramNIH$601K - $2M
 Howard Hughes Medical InstitutePrivate 
 National Centers for Biomedical Imaging and BioengineeringNIH$500K - $750K

Thermo Fisher Scientific does not guarantee (i) the accuracy or completeness of any information related to grants or funding resources or (ii) that you will receive any grant or secure any funding regardless of any assistance Thermo Fisher provides.


Thermo Fisher Financial Services

Thermo Fisher Financial Services helps you get the instrumentation and services your lab needs to achieve its research goals through a variety of funding paths that can be customized to meet your requirements.

What are your options?

  • The B2G program lets you achieve your cryo-EM goals while waiting for your grant to be awarded
  • Competitive and flexible financing
  • Leasing and lease-to-own options
Example timeline

Featured Thermo Fisher Financial Services Resources


Cryo-EM grant supporting documentation

Product datasheets

Selected reference guides

Cryo-Electron Tomography

Cryo-EM e-Learning

Ask the Experts Series

Ask the Experts webinar series

These interactive Q&A sessions offer you the chance to stay connected to the latest science through conversations on unique topics.

Watch sessions on-demand

Register for upcoming webinars


Cryo-EM webinars

Thermo Fisher Scientific offers monthly webinars to highlight the latest updates and insights from these cutting-edge techniques.

Single particle analysis



Integrative structural biology

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