Electron Microscopy

Bio-pharmaceutical Research with Electron Microscopy

Bio-pharma drug discovery through high resolution cryo electron microscopy.

Rather than starting with a disease and searching for its origin, protein-based biopharmaceuticals (biologics) begins with the detection of a genetic variation and then relies on therapies that manipulate it. Cryo-EM helps researchers examine a broad range of biological structures and provides the ability to visualize otherwise difficult or complicated biologics.

For example, protein samples, which are frozen in vitreous (non-crystalline) ice, can be examined in a near-native, fully hydrated state, thereby enabling accelerated structural drug discovery. Near-atomic-resolution cryo-electron microscopy can be employed throughout the drug discovery process, from target identification, through lead characterization, to epitope mapping.

 

 
Cryo EM structure of polyomavirus-like particle used in bio-pharmaceutical drug discovery.
Cyro-EM structure of BK polyomavirus-like particle in complex with single-chain antibody. PDB ID: 6GG0. Images created with Pymol by Hans Raaijmakers.
 
Cryo EM structure of polyomavirus-like particle used in bio-pharmaceutical drug discovery.
Cyro-EM structure of BK polyomavirus-like particle in complex with single-chain antibody. PDB ID: 6GG0. Images created with Pymol by Hans Raaijmakers.
 
Cryo EM structure of polyomavirus-like particle used in bio-pharmaceutical drug discovery.
Cyro-EM structure of BK polyomavirus-like particle in complex with single-chain antibody. PDB ID: 6GG0. Images created with Pymol by Hans Raaijmakers.
 
Cryo EM structure of polyomavirus-like particle used in bio-pharmaceutical drug discovery.
Cyro-EM structure of BK polyomavirus-like particle in complex with single-chain antibody. PDB ID: 6GG0. Images created with Pymol by Hans Raaijmakers.

Applications

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Structural Biology Research

Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

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Infectious Disease Research

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

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Drug Discovery

Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.

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Single Particle Analysis

Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

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Cryo-Tomography

Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›

Products

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Krios G4 Cryo-TEM for
Life Sciences

  • Improved ergonomics
  • Fits more easily into new and existing labs
  • Maximized productivity and automation
  • Best image quality for high-resolution 3D reconstruction

Vitrobot System

  • Fully Automated Sample vitrification
  • Blotting Device
  • Semi-Automated Grid Transfer
  • High Sample Throughput

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Electron microscopy services for
the life sciences

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.

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