Cryo-EM advantages
We created this learning center to connect researchers around the world to the latest information on cryo-electron microscopy (cryo-EM). While cryo-EM has been perceived as complex and out of reach, dramatic advancements over the last decade have made this technology more accessible and cost-effective than ever before. With cryo-EM, molecular details can be seen at biologically relevant resolution, helping researchers understand protein function and disease mechanisms, and facilitating effective drug design.
Cryo-EM learning center
This resource hub contains rich and reliable technical content designed for new and experienced researchers who are exploring the capabilities of cryo-EM. Learn about cryo-EM at your own pace. Our technical experts are here to support you every step of the way.
Shatter the limits of discovery with cryo-EM. We partnered with Bioz, the most comprehensive AI search engine for life scientists to help you find scientific papers relevant to your research. Use our new publications tool to expand or refine your search based on time frame, research area, technique, instrument, protein, and more! Subscribe to our monthly newsletter to receive a curated list of 4–5 recent publications.
Featured resources
Next steps
Cryo-EM expert testimonials
We have collaborated with researchers across the globe to develop content that can be consumed at any pace, from any place, free of charge!
EM-University
Visit EM-learning.com to learn about the foundations of cryo-EM, including the single particle analysis (SPA) workflow, via step-by-step instructions, expert demonstrations, and theoretical lessons.
Ask the Experts series
These interactive Q&A sessions offer you the chance to stay connected to the latest science through conversations on unique topics.
Expert interviews
Watch these interviews to learn how our customers and products are impacting the latest life science research.
Cryo-EM podcasts series
Get to know some members of our scientific community and their latest work.
Cryo-EM webinars
Cryo-EM is helping researchers unlock some of life’s greatest biological mysteries. Recent advancements to workflows and instruments enable scientists to expand their labs’ capabilities in a variety of therapeutic areas. Thermo Fisher Scientific offers monthly webinars to highlight the latest updates and insights from these cutting-edge techniques.
Ask the Experts series
These interactive Q&A sessions offer you the chance to stay connected to the latest science through conversations on unique topics. Register for upcoming cryo-EM Ask the Experts webinars.
Labroots Webinar series
We partnered with Labroots to offer webinars that are approved for Continuing Education credits. Our webinar collection has content for new users and experienced microscopists. Save your seat at upcoming webinars.
Single particle analysis webinars
Single particle analysis (SPA) is a cryo-EM technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Watch now
Cryo-tomography webinars
Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins and their spatial arrangements within the cell. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis. Watch now to see how cryo-ET is opening literal windows into cells.
See how
MicroED webinars
Micro electron diffraction (MicroED) is an exciting new technique with applications in the structural determination of small molecules and proteins. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. Learn how MicroED is transforming structural determination.
Integrative structural biology webinars
Integrative structural biology uses structural and functional information from various techniques, including mass spectrometry and cryo-EM, to arrive faster at a more complete picture of the protein and its function. See how integrating data helps you to understand structure-function relationships.
Learn more
Cryo-EM eBook
Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insights into how these proteins function in a way that other methods simply cannot. Use cryo-EM to get a broader picture of how membrane proteins function and contribute to disease to drive your research and improve drug design. Learn more about adopting cryo-EM and how it can advance your research.
Tomography eBook
Access the inner workings of cells through 3D sample reconstruction at unprecedented nanoscale resolution. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity. Explore a curated collection of publications highlighting the use of cryo-ET.
Virology eBook
Cryo-EM technology is helping researchers overcome challenges related to virus purification and protein homogeneity and revolutionizing antiviral drug discovery and vaccine design. Learn more about how cryo-EM can help solve structural puzzles in virology.
Oncology eBook
Leverage structural insights to better understand the conditions for cancer-cell growth and identify new ways to treat cancer. Learn how cryo-EM is revolutionizing cancer research.
Tundra drug discovery eBook
Accelerate your drug discovery and design with the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM). Download the eBook to discover how cryo-EM can enhance structural insights of drug targets to facilitate effective drug discovery and design.
Cryo-EM eBook
Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insights into how these proteins function in a way that other methods simply cannot. Use cryo-EM to get a broader picture of how membrane proteins function and contribute to disease to drive your research and improve drug design. Learn more about adopting cryo-EM and how it can advance your research.
Tomography eBook
Access the inner workings of cells through 3D sample reconstruction at unprecedented nanoscale resolution. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity. Explore a curated collection of publications highlighting the use of cryo-ET.
Virology eBook
Cryo-EM technology is helping researchers overcome challenges related to virus purification and protein homogeneity and revolutionizing antiviral drug discovery and vaccine design. Learn more about how cryo-EM can help solve structural puzzles in virology.
Oncology eBook
Leverage structural insights to better understand the conditions for cancer-cell growth and identify new ways to treat cancer. Learn how cryo-EM is revolutionizing cancer research.
Tundra drug discovery eBook
Accelerate your drug discovery and design with the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM). Download the eBook to discover how cryo-EM can enhance structural insights of drug targets to facilitate effective drug discovery and design.
Cryo-electron microscopy (cryo-EM) describes an increasingly popular group of techniques including single particle analysis, micro-electron diffraction, and cryo-tomography. These techniques are performed on cryo-transmission electron microscopes (cryo-TEMs), which are specialized TEMs designed to operate at cryogenic temperatures. Cryo-EM has gained popularity in various research areas like structural biology, biochemistry, and cell biology due to the structural and functional insights it provides. With cryo-EM, molecular details can be seen at biologically relevant resolution, helping researchers understand protein function and disease mechanisms, and facilitating effective drug design.
| High resolution structural characterization |
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| Reduced challenges during sample preparation |
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| Near-native research conditions |
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| Accelerate time to results |
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| Misperception | Fact |
| Cryo-TEMs are too expensive to purchase |
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| Cryo-EM labs are too expensive to maintain |
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| Cryo-EM labs require specific expertise and dedicated personnel |
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| Cryo-EM sample prep takes too long and data collection is too slow |
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Discover the facts behind the five most common misperceptions and learn how you can get started in cryo-EM.
We’ve made design improvements to our microscopes to address the need for a smaller footprint and easier access path. In many cases, this avoids the additional investment and unwanted lab downtime for significant modifications to an existing infrastructure or the need for a purposely built lab. See our Guidance for Planning a Cryo-EM Laboratory.
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As the market leader in cryo-EM, we are uniquely positioned to help you and your team be successful at every stage of the adoption process, from financing, to guidance on facility requirements, to data processing and analysis. Learn about the accessible cryo-EM workflow and how to get started in cryo-EM.
When you are ready to take the next step, our experts can provide support and recommendations for funding your laboratory. We created the Electron Microscopy Funding Support Center where you will find more technical content, proposal writing tools, and financing information.
Our experts are here to support you and your team every step of the way. We can:
- Help you gather the right information to submit a well-supported and accurate application.
- Get you preliminary data and rationale for your proposal.
- Provide information about financing and leasing solutions.
- Discuss ideal workflow solutions and recommendations for your lab.
- Schedule product demos.
- And so much more!
