Revealing conserved co-factor functions through structural analysis of alphacoronavirus polymerase
In this webinar, Dr. Robert Kirchdoerfer discusses how he and his team used cryo-electron microscopy to determine the structure of the alphacoronavirus porcine epidemic diarrhea virus (PEDV) core polymerase complex bound to RNA.
Cryo-EM reveals ligand binding in the SARS-CoV-2 spike protein and the human CDK-activating kinase
Dr. Basil Greber from The Institute of Cancer Research, London and Professor Christiane Schaffitzel from University of Bristol discuss how cryo-EM can uncover new insights into human disease, using the SARS-CoV-2 spike glycoprotein and CDK-activating kinase as case studies.
Structure-guided design of SARS-CoV-2 antivirals
Dr. Quan Wang of ShanghaiTech University and Dr. Renhong Yan of Westlake University discuss new cryo-EM studies of the structural basis of key molecular processes including RNA replication/transcription and receptor recognition.
Cryo-EM for virology and vaccine design
Dr. Jeff Lengyel, Thermo Fisher Scientific, discusses how cryo-electron microscopy has been used against viruses even the recent COVID-19 outbreak. Cryo-EM protein structure-based research has led to applications in virology and vaccine design.
Using cryo-EM for designing next-gen therapeutics against HIV
Prof. Dmitry Lyumkis, Salk Institute for Biological Studies, discusses how HIV’s ability to integrate its genome into host DNA is vulnerable to inhibition and how cryo-EM studies for structure-based drug design can help combat global HIV epidemic.
Untangling neurodegenerative diseases using cryo-electron microscopy
Prof. Anthony Fitzpatrick, Columbia University, discusses how cryo-EM solves structures of amyloid fibrils from patient post-mortem brain tissue with a range of neurological disorders & elucidates the molecular/structural basis of neurodegeneration.
Unraveling the structure of toxic protein aggregates in situ by cryo-electron microscopy
Dr. Rubén Fernández-Busnadiego, MPI Biochemistry, discusses how cryo-electron tomography imaging of protein aggregates within cells illuminates their mechanisms of cytotoxicity.
Structure of alpha-synuclein fibrils by cryo-electron microscopy
Ricardo Guerrero-Ferreira, Univ. Basel, covers cryo-EM structure of alpha-synuclein fibril and implications of this fibril structure on amyloid fibril elongation and the rational design of biomarkers for early detection of synucleinopathies.
Understanding malaria parasite pathogenesis by cryo-electron microscopy
Prof. Chi-Min Ho, Columbia University, discusses how employing the unique strengths of single particle cryo-EM as an experimental tool presents opportunities for structure-based design of anti-malarial drugs.
Structural Oncology - Fighting Cancer with Cryo-EM
Dr. Deborah Kelly from Penn State University’s Center for Structural Oncology discusses rational drug design based on structural insights with cryo-EM.
Cryo-electron microscopy and the complexity of cancer
Dr. Simon Poepsel, UC Berkeley, explains how single-particle cryo-electron microscopy enables us to gain insight into cancer development through the detailed analysis of molecular structure, covering both biology and methodology.
Harnessing cryo-EM to investigate GPCR structure and discover new medicines
Drs. Matthew Belousoff of Monash University and Stacey Southall of Sosei Heptares discuss the cryo-EM role in understanding the structural biology of GPCRs, facilitated by structure-based drug design (SBDD) approaches is critical for delivering first-in-class and best-in-class drugs.
The emerging role of cryo-electron microscopy in drug discovery
Rob Cooke, SVP Biomolecular Structure, discusses how single particle cryo-electron microscopy (cryo-EM), no longer a niche technique, provides a prevailing direction to obtain high-resolution structure information on proteins without crystallization.
Determining protein and small molecule structures with Microcrystal Electron Diffraction
Dr. Tamir Gonen, UCLA, and Dr. Christopher Arthur, Genentech, describe the new method of MicroED and explore advances for small molecule & protein structure in pharma.
How to successfully adopt cryo-electron microscopy for non-experts
In recent years, cryo-EM has rapidly developed into a mainstream application that can achieve atomic resolution for challenging proteins and is now becoming increasingly easy, affordable, and accessible. In the webinar, Dr. Alevtyna Yakushevska explains how to get started with cryo-EM.
Thermo Scientific Falcon 4 Direct Electron Detector enhances cryo-EM productivity and performance
In today’s demanding structural biology community, there is an increased demand for higher productivity and improved performance (i.e. higher resolutions). The powerful combination of the latest generation direct electron technology (Thermo Scientific Falcon 4) and the industry leading microscope platforms Krios G4 and Glacios enables this requirement. In this webinar, Dr. Marc Storms will discuss the unique value of the Falcon 4, in conjunction with the Krios G4 and Glacios, is explained and exemplified with real applications data.