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Electron Microscopy

Single Particle Analysis

Single particle cryo electron microscopy for structural biology at near-atomic resolution.

 

Investigating biomolecules at near-atomic resolutions allows you to explore the very architecture of life. Cryo electron microscopy (Cryo-EM) single particle analysis is rapidly becoming a mainstream structural biology technique, facilitating the study of:

  • Dynamic biological processes
  • Protein structure
  • Protein complexes and aggregates
  • Large virus assemblies

Cryo-electron microscopy is a multi-step process. See how it can speed up your research and development with our single particle analysis workflow:

Learn more about the single particle analysis workflow ›

Multi-level support at every stage

You can rely on our expertise to support both your investment and your research endeavors. Our highly knowledgeable cryo-EM application specialists can assist with everything from sample preparation to data processing. Rest assured when you trust your long-term ongoing support to a cryo-EM leader currently supporting 100+ systems worldwide.

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Advice for planning and building

Control costs and limit laboratory downtime by relying on our advanced expertise of lab infrastructure. Thermo Fisher Scientific offers the expertise you need to precisely plan every aspect of your laboratory, helping to reduce building costs, while optimizing your laboratory for the best results.

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Flexible options to get you in the game

We provide a variety of ways to meet your financial needs, from assistance with grants to leasing and financing options. Our experts are well versed in the unique procurement requirements of universities, governments, industry and research labs.

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Media Gallery

Structure-guided design of SARS-CoV-2 antivirals

Register to watch our recorded webinar from Dr. Quan Wang of ShanghaiTech University and Dr. Renhong Yan of Westlake University on new cryo-EM studies of the structural basis of key molecular processes including RNA replication/transcription and receptor recognition.

Register now

Determining protein and small molecule structures with Microcrystal Electron Diffraction.

Structure-guided design of SARS-CoV-2 antivirals

Register to watch our recorded webinar from Dr. Quan Wang of ShanghaiTech University and Dr. Renhong Yan of Westlake University on new cryo-EM studies of the structural basis of key molecular processes including RNA replication/transcription and receptor recognition.

Register now

Determining protein and small molecule structures with Microcrystal Electron Diffraction.

Applications

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Structural Biology Research

Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

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Infectious Disease Research

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

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Drug Discovery

Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.


Samples


Proteins Analysis

Cryo-electron microscopy provides near-atomic resolution 3D protein structure. It can determine structural information for complexes and crystallization-resistant samples, as well as vital cellular context.

Learn more ›


Virus Analysis

Cryo-EM enables the 3D structural visualization of virus particles, and the antigen-antibody interface, at near-atomic resolutions. A virus’s inherent structural symmetry makes it the ideal target for cryo-EM analysis.

Learn more ›


Products

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Krios Rx Cryo-TEM

  • Industry leading productivity and ease of use
  • Fixed 300 kV voltage for SPA only
  • Pharma-dedicated service package for guaranteed reliability

Krios G4 Cryo-TEM

  • Improved ergonomics
  • Fits more easily into new and existing labs
  • Maximized productivity and automation
  • Best image quality for high-resolution 3D reconstruction

Glacios Cryo-TEM

  • Flexible Accelerating Voltage 80-200 kV
  • Industry-leading Autoloader for cryogenic sample manipulation
  • Small footprint
  • Enhanced ease-of-use

Tundra Cryo-TEM

  • Structural information at biologically relevant resolution
  • Space efficient and cost effective
  • Easy, iterative sample optimization
  • Unique AI algorithms for streamlined data collection

Talos Arctica TEM

  • Increased data acquisition speed
  • High data with robotic sample handling & automated loading
  • Unattended platform operation and automated data acquisition
  • Low cost of ownership with remote diagnostics and preventive service

Vitrobot System

  • Fully Automated Sample vitrification
  • Blotting Device
  • Semi-Automated Grid Transfer
  • High Sample Throughput

Selectris and Selectris X Imaging Filters

  • Designed for high stability and atomic resolution imaging
  • Straightforward operation
  • Paired with the latest generation Thermo Scientific Falcon 4 Direct Electron Detector

Falcon 4 Detector

  • Leading detective quantum efficiency
  • 10x shorter exposure time than its predecessor
  • Fully embedded in Thermo Scientific software
  • Built in data management

EPU 2 Software

  • Microscope-embedded solution for single particle acquisition
  • Optimized for high-throughput particle collection
  • Compatible with film, CCD cameras, and direct electron detectors

EM Services for Single Particle Analysis

  • Empower your users so they can work with confidence
  • Keep step-by-step workflow guidance at your fingertips
  • Get set up for success with Workflow Validation

Contact us

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