Accessories for Electron Microscopes

Falcon 4 Direct Electron Detector

Direct electron detection with enhanced image quality, efficient data compression and productivity.


The Thermo Scientific Falcon 4 Direct Electron Detector is the ideal solution for your single particle analysis (SPA) and cryo tomography applications. With its unique combination of highest image quality, high throughput, efficient lossless data compression enabled via EER and a streamlined solution for data management and quality monitoring, the Falcon 4 enables a productivity and performance boost that meets the demands of today’s scientific and industrial communities.

Note: The Falcon 4 Direct Electron Detector is fully compatible with the Thermo Scientific Krios G4 and Krios Rx Cryo-TEM as well as the Thermo Scientific Glacios and Arctica Cryo-TEMs if running under Windows 10.

Selectris and Selectris X Imaging Filters

Designed for stability and speed, the Thermo Scientific Selectris and Selectris X Imaging Filters are post-column imaging filters that improve the contrast of TEM images, resulting in high-resolution structures up to atomic resolution. Paired with the latest generation Thermo Scientific Falcon 4 Direct Electron Detector, Selectris Filters enable you to obtain high-resolution structures quickly, revealing new biological insights. To further increase the productivity and ease-of-use of your cryo-electron microscopy (cryo-EM) research, these filters are fully integrated into Thermo Scientific EPU Software, Thermo Scientific Tomography Software, and instrument operation software. The Selectris and Selectris X Imaging Filters are available on Thermo Scientific Krios and Glacios Cryo-TEMs.

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Key Features

  • Leading detective quantum efficiency (DQE) across full spatial frequency range
  • High throughput for faster results
  • Electron Event Representation (EER) enabling lossless data compression while maintaining full temporal and spatial resolution
  • Fully embedded into Thermo Scientific EPU and Tomography Software
  • Built-in data management (powered by Athena) for remote and collaborative access

Specifications

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Camera architecture Direct electron detection
Sensor size 4,096 × 4,096 pixels, ~ 5.7 x 5.7 cm2
Pixel size 14 x 14 μm2
TEM Operating voltage 200 kV, 300 kV
Mounting position On-axis, bottom mounted, retractable
Frame rate 250 fps internal frame rate
File Format EER super resolution up to 16k x 16k. All counted frames (~240 fps) accessible/written to disk, fractionation not required
MRC
Detection modes Electron counting mode
Survey mode (fast linear mode)
Imaging performance 4k x 4k DQE* in EC mode DQE(0) = 0.90
DQE(1/2 Nq) = 0.70
DQE(1 Nq) = 0.28

*measured at 300kV, 1.5 e/p/s
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Applications

Infectious_Disease_Research_App_w274x180

Infectious Disease Research

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

DrugDiscovery_Appl_274x180

Drug Discovery

Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

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Cryo-Tomography

Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

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Integrative Structural Biology

To understand protein function, you need complex and structure information beyond individual proteins. Integrative structural biology combines mass spectrometry and cryo EM for the determination of large dynamic complex structure.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

Integrative Structural Biology

To understand protein function, you need complex and structure information beyond individual proteins. Integrative structural biology combines mass spectrometry and cryo EM for the determination of large dynamic complex structure.

Learn more ›

Documents

Datasheets


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Electron microscopy services for
the life sciences

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.

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