Wherever imaging datasets need to be processed and managed, Thermo Scientific software solutions offer state-of-the-art image data processing, exploration, and analysis features. Our adaptable software packages dedicated to life sciences, materials science, and digital rock analysis evolve regularly. New features, improvements, and new Xtras developed with scientific experts deliver best-in-class analytical software solutions tailored to your needs.

Amira Software, Avizo Software, and PerGeos Software version 2022.1 roll out exciting new tools and enhancements.


The Segmentation+ workroom evolves in Amira Software and Avizo Software

The goal of segmentation is to simplify and/or change the representation of an image into something that is more meaningful and easier to analyze. More precisely, image segmentation is the process of assigning a label to every pixel in an image in a way that pixels with the same label share certain characteristics. To this end, Avizo Software contains a segmentation workroom, and since 2021.2 we have introduced a new version called Segmentation+ workroom. We are continuing to add tools and new features to enrich it.

Superpixel

The new Superpixel tool allows you to brush and select “superpixels” (groups of smart pixels) and create a voxel selection out of them. It will dramatically increase the speed and accuracy of your selection. Compared with the former tool, the Superpixel brush lets you “paint” much faster without having to precisely follow the contours of your selection.

Threshold

Threshold tool has been available in our Classic workroom for some time and is now ready to use in our new Segmentation+ workroom. This tool allows you to create a voxel selection from a threshold range, either in the current slice or in 3D.

Interpolate slices

The Interpolate tool allows you to interpolate the selection between parallel slices. You can segment only a fraction of the slices within your dataset. This new implementation in the Segmentation+ workroom is based on the same algorithm used in the Classic Segmentation workroom and has been enhanced to affect both Segmentation workrooms. This tool allows increased productivity of highly manual segmentation cases, handled with tools such as brush, Superpixels or Threshold. Thanks to the new acceleration, the tool performs significantly faster than before (3 to 4 times faster on a 12-core CPU).


New deep learning modules for segmentation in 2D and 3D in Amira Software, Avizo Software and PerGeos Software

Faster segmentation in 2D through single large 2D data slice tiling.

A new module called “DL Training - Segmentation 2D” is now available for 2D image-based deep learning model training. With it, tiling is now possible.

The tiling functionality allows you to automatically split a single large 2D data slice (input data) into tiles (multiple sub-slices of the same size), each tile being considered as an independent training sample. In addition, it is now possible to randomize the order of the training samples before assigning samples in training and validation sets.

Increase quality of your segmentation in 3D

A new module called “DL Training - Segmentation 3D” is now available for 3D image-based deep learning model training. As with “DL Training - Segmentation 2D,” this new module relies on 3D convolutions rather than 2D for ResNet and VGG-backboned U-Nets and generic U-Nets.

The tiling functionality splits the input volume into independent training samples.This new module allows training 3D models that better account for 3D object shapes, and better prediction results quality can be expected.

Amira-Avizo_Deep-learning-modules

Better segmentation of 3D non-spherical objects in Amira Software, Avizo Software and PerGeos Software

The new Random-Walk Distance Map module computes a distance map from binary segmentation, reflecting for each foreground voxel the average time it takes to do a random walk from this voxel to a background voxel. Compared with Euclidean or Chamfer distance maps, this module is less affected by noise in the segmentation or objects of anisotropic shapes. It is therefore particularly well-suited for object separation workflows in the case of non-spherical objects and/or noisy segmentation data.

Using separate object
Using Separate Object
Random-Walk Distance
Using Random Walk Distance Transform

Xplore5D extension evolves in Amira Software

Enhanced user experience for large data conversion to SMS format

The SMS Converter is a tool embedded in the Amira Software Xplore5D extension, designed to easily and rapidly convert customer datasets into Thermo Fisher Scientific custom Out Of Core file format: SMS. The conversion step of your data is now guided and interactive.

New file formats supported

For users' convenience, the Xplore5D SMS Converter now supports a wide variety of file formats such as .tif, .tiff, .cif, and many others, thanks to the Bio-Formats third party library that provides more than 150 different formats. Using Bio-Formats, the SMS Converter supports single file multichannel datasets, single file time-series datasets, and single multichannel time-series datasets.


Quantitative analysis in ISP and IVP recipes

The following modules can now be used within the ISP and IVP workrooms and recipes:

  • Label Analysis
  • Global Analysis
  • Sieve Analysis
  • Analysis Filter

When you select a spreadsheet associated with one of these modules, the viewer will display the contents of the spreadsheet. Thanks to the addition of analysis modules directly in your recipes, you will be able to further automate your analysis and create more comprehensive recipes. You are now able to create recipes that embed all steps from image processing to quantification of individual objects and export the resulting spreadsheet.


Camera Bookmark, a new visualization module in Amira Software and Avizo Software

The versatility of the Camera Bookmark allows you to easily design your visual inspection scenarios, and with the ability to use them in animations, you will maximize the impact of the features you want to highlight through visual exploration of your data.



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Amira-Avizo Software and PerGeos Software release notes

​ Amira-Avizo Software release notes

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

PerGeos Software release notes

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.

Amira-Avizo2D Software release notes

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo2D Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo2D Software runs on, and a list of solved issues.


How to receive upgrades

Regular upgrades including new features and enhancements are provided free-of-charge to all users under valid maintenance.



What was new

Road to next-generation workroom: high-performance segmentation of large data sets

With the widespread adoption of high-performance imaging systems, the file size of the imaging data is constantly increasing. As a result, segmenting and interpreting very large data is becoming a challenge.

The 2021.2 release of Thermo Scientific Amira-Avizo Software introduces the first version of our next generation segmentation workroom, Segmentation+.

This new workroom is based on an innovative technology and user interface that supports interactive segmentation of large image data and an unlimited number of material labels which can be organized into groups. With this initial release, the Segmentation+ workroom delivers performance improvements by a factor of three to five on 16k*16k 3D image data segmentation.

The first version of the Segmentation+ workroom includes a Brush Tool for segmentation, but newer versions will be equipped with additional segmentation tools and features.

The Classic Segmentation Editor with all the tools you know remains fully available and you can switch between both tools at any time.

Amira-Avizo segmentation+

High-performance DVC made easier

The Digital Volume Correlation (DVC) tool available in Amira-Avizo Software allows you to compute 3D full-field displacement and strain maps from volume images acquired during the deformation process of an object. DVC is an innovative, powerful contactless, bulk strain measurement technique in experimental mechanics, materials science, and biomechanics.

Amira-Avizo Software offers a truly unique and complete high-performance DVC solution. One of its main differentiators is the availability of the ‘Global Approach’ which allows for high-precision measurement of deformation phenomena.

As a first step, this Global Approach requires building a 3D mesh that conforms to the 3D shape of the object. Building such a high-quality continuous, homogeneous mesh requires some expertise and several manual steps.

The 2021.2 release of Amira-Avizo Software introduces a high-performance meshing technology that dramatically reduces the time and the complexity to build a high-quality mesh, ideal for the Global DVC Approach. 

This offers full access to a complete and powerful DVC solution even for non-expert users. 

Learn more about Digital Volume Correlation for Amira-Avizo Software

Amira-Avizo Software improvements and new add-ons

Various improvements come with this Amira-Avizo 2021.2 release, including enhancements to the newly released XPlore5D extension for multi-channel and time-series visualization, enhancements to the Python API, a major update of the BioFormats library, multiple enhancements to the MRC reader, and more.

Amira-Avizo 2021.2 also offers many new how-to’s video tutorials that will improve your productivity in several analysis workflows, such as advanced use of Colormaps, efficiently registering and merging images, fully benefiting from the automation capabilities of the Image Stack Processing workroom, and more.

This release also addresses several known bugs and limitations


Amira-Avizo Software and PerGeos Software release notes

​ Read the full Release Notes for Amira-Avizo Software

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

Read the full Release Notes for PerGeos Software

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.

Explore very large multi-channel and time series imaging data with the Xplore5D extension for Amira Software.

Thanks to accelerated innovations in microscopy, life scientists now have access to a growing suite of imaging tools and techniques. Used alone or in combination with one another, high-powered instruments give researchers new ways to study biomolecular activity and advance their respective scientific discoveries. Yet, the increase in adoption of microscopy techniques in life science research results in increased size and volume of the imaging data acquired.

This abundance of data challenges the memory limits of scientists’s workstations and requires imaging software that is optimized for handling such high-resolution, multi-channel, and time series imaging data.

The new Xplore5D extension for Amira Software allows cell biologists to interactively explore very large multi-channel and time series imaging data. It is powered by a unique, lossless compression technology and features a user interface dedicated to interactive navigation in multi-channel time series imaging data. Xplore5D addresses the growing challenges of handling large imaging data, helping life scientists improve productivity and enabling the build of meaningful answers to complex questions across all fields of biomedical research.

Learn more

Xplore5D

Enhanced Deep Learning capabilities

The 2021.1 release of Amira-Avizo Software comes with additions in Deep Learning capabilities:

  • Automatic labeling of multiple image features at the same time using multi-class segmentation
  • More neuron network models can be used, including Resnet, which has performance proven to be much higher with the same precision
  • Increased accuracy with same computation time in several challenging segmentation cases, such as 3D characterization of cell ultrastructures, which are key for precision therapy research
  • Generation of label maps (instead of probability maps) with the new Deep Learning prediction module
  • Multiple improvements in performance, usability, and customization capabilities that make this enhanced Deep Learning framework a cutting-edge tool for automated imaging data analysis
Deep learning

​Read the full Release Notes for Amira-Avizo Software

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

Read the full Release Notes for PerGeos Software

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.

Digital Volume Correlation reached the next level

With a set of new features, Digital Volume Correlation 2020.3 makes it easier and faster to compute the 3D full-field displacement and strain maps from a reference volume to a deformed volume. DVC 2020.3 introduces a unique pre-processing module to quantify the displacement and strain uncertainties from two repeat scans and to help you ensure the reliability of your DVC analysis.

User experience has been improved with local and global approaches now separated in dedicated modules. The mesh generation used in the global approach can also be called from a separate module. You can now speed-up and automate your incremental DVC analysis (local or global) on a series of deformed volumes to capture the mechanical history of your specimen. Two strategies are proposed to take into account the level of cumulated strains (small or large).

DVC 2020.3 offers many new post-processing tools:

  • One-click extraction of displacement vector and strain tensor components
  • One-click computation of the Green-Lagrange strain tensor from a displacement field Enhanced visualization tools for scalars and vectors; easy color mapping on volumes, meshes, and surfaces
  • Median filter computation to smooth the displacement field resulting from DVC global approach and to correct its spurious vectors
  • More conversion and export capacities, such as Excel spreadsheet format, are available for you to perform further analysis with Python codes, FE-solvers, etc.
  • New tutorials and enriched documentation will help you quickly get up-to-speed with these new features.
DVC Module

New EM Toolbox suite for automated processing of large image stacks

Large stacks of serial sections must be aligned and often require denoising and contrast enhancement. These actions are time-consuming and demand powerful hardware. EM Toolbox offers powerful algorithms, is easy to use, and is able to perform tasks in a reasonable time, no matter which hardware is available.

EM Toolbox offers:

  • Post-processing workflow for Large Image Stacks (LVA) (out-of-core processing)
  • Straightforward configuration and execution of the workflow
  • Workflow: slice alignment, including reduction of distortions; image denoising; and contrast enhancement
EM Toolbox

​Read the full Release Notes for Amira-Avizo Software

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

Read the full Release Notes for PerGeos Software

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.

Scale bar

Amira-Avizo Software 2020.2 introduces a new 2D ScaleBar module that can now be used with any orthoslice and any type of data, including RGB images, multi-channel, or large data.

Scale Bar

Relabel By Track ID – Amira Software for Cell Biology

The Relabel By Track ID is a new module that allows you to relabel a Time Series of segmented objects to match their corresponding Track ID. This enables the visualization of the results of the object tracking step using Slices or Voxelized Rendering. The Object Tracking Tutorial has been updated to explain how to use this new module

Relabel By Track ID

Molecule DNA-RNA Visualization

This Amira Software module visualizes the typical ladder structure of double-stranded DNA or single-stranded RNA structures. Each strand consists of multiple nucleotides with four different base types (Adenin, Cytosine, Guanine, and Thymine for DNA; and Adenine, Cytosine, Guanine, and Urazil for RNA). The backbone part of the nucleotide will be shown as a strand with an elliptical cross section and the bases as elliptical cylinders with different patterns at the ends, called sticks.

Instead of the sticks, you can visualize the sugar rings of the backbone in combination with the single-ring pyrimidines or the double-ring purines of the bases. The module provides several coloring modes that color either the DNA/RNA specific properties or general molecular properties.

The DNA-RNA Visualization module is available under the Avizo Software XMolecular and Amira Software XMolecular extension licenses.

Molecule DNA-RNA Visualization

Visualization of DNA and secondary structures of a nucleosome.N. Lindow, D. Baum, M. Leborgne, H.-C. Hege (2019). Interactive Visualization of RNA and DNA Structures. IEEE Transactions on Visualization and Computer Graphics, vol. 25, no. 1, pp. 967-976.

New option: Multiple Hypothesis Tracing for module Trace Correlation Lines

This new option allows for more robust results to be obtained, especially in the context of dense fibers and low data contrast. Multiple Hypothesis Tracing, proposed in the module Trace Correlation Lines, is included in Amira Software XTracing and Avizo Software XFiber extensions.

Multiple Hypothesis Tracing

Tracing of Microtubules in electron tomography images, with and without Multiple Hypothesis Tracing. The orange volume rendering displays the correlation field, and colored tubes show the traced centerlines.
Friman, O., Hindennach, M., Kühnel, C., Peitgen, H.-O. (2010). Multiple hypothesis template tracking of small 3D vessel structures. Medical Image Analysis, 14:160-171.

​Read the full Release Notes for Amira-Avizo Software

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

​Read the full Release Notes for PerGeos Software

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.

New look and feel

Amira-Avizo Software 2020.1 introduces a new look and feel based on dark, contrasting visuals. This new user interface offers a more modern appearance. For those using other Thermo Scientific electron microscopy applications, the user experience will be enhanced, as the look and feel is consistent across software suites. These enhancements provide better readability, which improves comfort by reducing eye strain. And they save energy, too. Additionally, support for 4K displays has also been greatly improved.

Amira Avizo GUI

ScaleBar

The 2D ScaleBar module has been enhanced to enable the display of bar length using the currently selected display unit, improving visibility regardless of image contrast.

Scale Bar

Read the full Release Notes for Amira-Avizo Software

The Release Notes allow you to gather a deeper knowledge about this new version of Amira-Avizo Software. They include more technical explanations, compatibility notes, operating systems Amira-Avizo Software runs on, and a list of solved issues.

Read the full Release Notes for PerGeos Software

The Release Notes allow you to gather a deeper knowledge about this new version of PerGeos Software. They include more technical explanations, compatibility notes, operating systems PerGeos Software runs on, and a list of solved issues.


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Products

Thermo Scientific Amira 2D-5D visualization Software

Amira Software
Life Sciences

  • Explore 2D-5D bioimaging data
  • Identify and understand structures
  • Obtain statistical information
  • Share reports and stunning animations

Avizo Software
Materials Science

  • Support for multi-data/multi-view, multi-channel, time series, very large data
  • Advanced multi-mode 2D/3D automatic registration
  • Artifact reduction algorithms

Pergeos Software
Rocks and Minerals

  • Visualize, process, and analyze rock imagery data
  • Perform multi-scale imaging analysis from pore to core
  • Calculate geological and petrophysical properties

Athena Software
Imaging Data Management

  • Ensure traceability of images, data, metadata and experimental workflows
  • Simplify your imaging workflow​
  • Improve collaboration
  • Secure and manage data access​

Services

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Introductory training

Shorten your learning curve and maximize your investment with this introductory training specifically designed for new users of Amira, Avizo and PerGeos Software.

The course consists of a lecture with hands-on sessions. The training material highlights the basic features and functionalities of Amira, Avizo and PerGeos Software.

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Advanced training

Maximize your investment and reduce your time-to-results with this advanced training specifically designed for existing users of Amira, Avizo and PerGeos Software.

The course consists of a lecture with hands-on sessions. The training material highlights advanced features and functionalities of Amira, Avizo and PerGeos Software.

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Custom development

With over 25 years of experience in 3D and image processing and hundreds of custom projects delivered to organizations small and large, Thermo Fisher Scientific can provide you with a solution tailored to fit your specific needs.

We can customize and expand our software solutions at various levels.


Features

Import and process your imaging data

    • Handle any modality, at any scale, of any size:

    - Bio-Formats
    - Bitmap formats
    - Microscopy: electron and optical
    - Medical and neuroimage formats
    - Molecular formats
    - Other acquisition devices (MRI, radiography, etc.)

    • Finite element modeling, geometric modeling, CAD
    • Support for multi-data/multi-view, multi-channel, time series, very large data
    • Scaling, calibration, conversion, re-sampling
    • Image enhancement, comprehensive filtering and convolution, Fourier frequency transforms
    • Artifact reduction algorithms
    • Advanced multi-mode 2D/3D automatic registration
    • Image stack alignment, arithmetic, correlation, fusion

    Easily segment your imaging data

    • Thresholding and auto-segmentation, object separation, automatic labeling
    • Region growing, snakes, interpolation, wrapping, smoothing
    • Morphological processing, including watershed and basins
    • Machine Learning-based segmentation
    • Automatic tracing of individual fibers and filaments
    • Skeletonization and filament network extraction
    • Interactive tools for generation or editing of segmentation and spatial graphs
    • 3D surface reconstruction
    • Grid generation for FEA/CFD

     

    Export your analysis and visualization work to seamlessly publish and present it

    • Animation and video generation
    • Advanced key frame and object animation
    • Mix images, geometric models, measurements and simulations
    • Annotations, measures legends, histograms and curve plots
    • Export spreadsheets, 3D models, high-quality images
    • Active and passive 3D stereo vision
    • Single and tiled screen display
    • Immersive environment

    Visualize and explore your imaging data

    • Interactive high-quality volume and multichannel visualization
    • Orthogonal, oblique, cylindrical and curved slicing
    • Contouring and iso-surface extraction
    • Maximum Intensity or other types of projections
    • Vector and tensor visualization
    • Objects and tracks
    • Molecular visualization

    Analyze your imaging data and obtain quantitative information

    • Intuitive recipe creation, customization, automated replay
    • Built-in measurements, including counts, volumes, areas, perimeters, aspect ratios and orientations
    • User-defined measures
    • Results viewer with spreadsheet tool and charting
    • Automatic individual feature measurements, 3D localization and spreadsheet selection
    • Automated statistics, distribution graphs
    • Feature filtering using any measurement criterion
    • Data registration, deformation, comparison and measurements

     

    Easily and quickly adapt Amira Software to your specific needs

    • Custom C++ modules development
    • MATLAB™ bridge
    • Python scripting API

    Contact us

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