Smart EPU Software with Embedded CryoSPARC Live

We have collaborated with Structura Biotechnology Inc. to develop an integrated version of CryoSPARC Live™ to significantly enhance efficiency of Thermo Scientific cryo-transmission electron microscopes (cryo-TEMs). Embedded CryoSPARC Live significantly shortens time to results by providing real-time, multi-dimensional feedback on sample quality and transmission electron microscope settings. It allows you to adjust imaging and processing parameters at any time, increasing overall data quality and minimizing time wasted on poor quality samples. And it fully integrates with Thermo Scientific Smart EPU Software to support for a growing set of automations.

Embedded CryoSPARC Live is installed on microscope hardware. Our digital service team provides support through installation and maintenance, and our application specialists provide integral workflow training.

Key benefits of Smart EPU Software with Embedded CryoSPARC Live

Ease of use

The simple guided workflow, intuitive user interface, and integration with Smart EPU Software ensure usability for researchers spanning a broad range of scientific expertise.


Seamless integration with Smart EPU Software enables real-time decision making and helps you easily enact optional data acquisition strategies. Easily export Embedded CryoSPARC Live sessions for more advanced downstream processing in CryoSPARC™.


Embedded CryoSPARC Live can significantly shorten time to results:

  • Provides real-time feedback on instrument settings and sample quality
  • Assists with on-the-fly decisions about changing grids and selecting squares and holes to optimize data quality
  • Addresses preferred orientation and other quality issues with real-time 2D and 3D information
  • Allows adjustment of imaging and processing parameters on the fly and rapidly identifies the presence or absence of expected targets


Embedded CryoSPARC Live works flawlessly with Smart Plugins from Smart EPU Software to adjust auto processing settings, and it fully integrates with Thermo Scientific Athena Software’s data management platform for automatic data exchange and improved ease of use.

CryoSPARCTM and CryoSPARCLiveTM are trademarks of Structura Biotechnology Inc. and are used under license.

On-demand webinar: Smart EPU with Embedded CryoSPARC Live

In this on-demand webinar, you will learn how Embedded CryoSPARC Live:

  • Seamlessly integrates into an automated single particle analysis workflow for easier operation, improved efficiency, and productivity
  • Can feed Smart Plugins to automatically adjust data collection settings on the fly for higher data quality
  • Offers real-time image analysis and facilitates post-processing

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