The Thermo Scientific Talos Arctica Cryo-TEM is a powerful, stable, and versatile 200kV FEG scanning and transmission electron microscope (S/TEM) built for delivering high-resolution 3D characterization of biological samples and biomaterials in cell biology, structural biology, and nanotechnology research. The Talos Arctica S/TEM enables scientists to quickly obtain better insight and understanding of macromolecular structures, cellular components, cells, and tissues in three dimensions.

Transmission Electron Microscopes

Structural Biology with Cryo STEM: Talos Arctica Cryo-TEM

3D cryo TEM analysis tool for biological samples and biomaterials.


Key Features

Fast 200 kV FEG S/TEM for sample analysis in multiple dimensions

The Talos Arctica Cryo-TEM is built to deliver rapid access to 2D and 3D data so that you can concentrate on discovery. The system's constant-power, C-Twin lens has outstanding optical performance, ensuring an optimal balance of contrast and resolution. Additionally, the ultra-stable platform includes a piezo stage with stable electronics and a rugged system enclosure for maximum thermal and mechanical stability.

Increased data acquisition speed

Acquisition speeds have been improved up to 3 times for tomography and up to 1.5 times for single particle analysis (with Thermo Scientific EPU Software) compared to side entry loading systems.

High data throughput

Robotic sample handling and automated loading for up to 12 samples provides up to 40% enhancement in data throughput.

Unattended operation

Auto-filling of liquid nitrogen and powerful applications software allows for continuous unattended platform operation and automated data acquisition.

Low cost of ownership

New design allows for remote diagnostics and preventive service, lowering ownership cost and maximizing systems uptime.


Specifications

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Source

  • High-brightness field emission gun (X-FEG)
  • Accelerating voltage
  • 80–200 kV
  • Cryo-Autoloader
  • Automated and contamination-free loading of cassettes, containing up to 12 Autogrids
  • Software
  • EPU Software for SPA screening and data acquisition
  • Temperature management software – Includes liquid nitrogen autofill and cool down scheduling
  • Low-dose software suite minimizes electron dose during cryo-TEM operation
  • Lenses
  • Automatic condenser, objective and SA apertures
  • Symmetric constant power objective lens (minimize image aberrations and lens hysteresis during mode switching)
  • Stages
  • Computerized 4-axes specimen stage with ±70° alpha tilt
  • Cryo-stage with single axis holder
  • Imaging
  • Rotation-free imaging upon magnification changes
  • Pole piece gap
  • 11 mm
  • Structural components
  • Two 24” monitors to be placed within 10 m of the column
  • Cameras
  • Digital FluCam – All manual and automatic alignments can be executed with the search and view camera
  • Ceta 16M Camera
  • Installation requirement highlights
  • Environmental temperature: 18°C – 23°C
  • Size: 5765 x 3895 x 3030
  • Detectors (optional)
  • Falcon 3EC Direct Electron Detector
  • HAADF STEM detector
  • On-axis BF/DF detectors
  • Software (optional)
  • STEM and TEM tomography software
  • Service package
  • Accelerate integrated service and application support packages
  • Other options
  • Volta phase plate 
  • compatible with Gatan post column imaging filter
  • Operating system
  • Windows 10
  • Style Sheet for Techniques Only Tab

    Applications

    Infectious_Disease_Research_App_w274x180

    Infectious Disease Research
     

    Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

    DrugDiscovery_Appl_274x180

    Drug Discovery
     

    Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.

    Life_Sciences_Application_274x180_144DPI

    Structural Biology Research
     

    Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

    Single Particle Analysis

    Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

    Learn more ›

    Cryo-Tomography

    Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

    Learn more ›

    MicroED

    MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

    Learn more ›

    Single Particle Analysis

    Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

    Learn more ›

    Cryo-Tomography

    Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

    Learn more ›

    MicroED

    MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

    Learn more ›

    Documents

    Datasheets


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