The Thermo Scientific Talos L120C TEM is a 20-120 kV thermionic (scanning) transmission electron microscope uniquely designed for performance and productivity across a wide range of samples and applications, such as 2D and 3D imaging of cells, cell organelles, asbestos, polymers, and soft materials, both at ambient and cryogenic temperatures. The Talos L120C TEM is designed from the ground up to allow users at any skill level to acquire high-quality results with minimal effort. Fast, sophisticated automation and advanced 3D imaging workflows allow applied researchers to focus on scientific questions rather than microscope operation.

Multi-user, multi-material, multi-discipline

The Talos L120C TEM takes imaging to the next level with the optional, motorized, retractable cryo box and low-dose technique, producing quality images even for beam-sensitive materials. To enhance productivity, especially in multi-user, multi-material environments, the constant-power objective lenses and low-hysteresis design allow for straightforward reproducible mode and high-tension switches.

The large pole-piece gap of the high-contrast C-Twin lens, which provides high application flexibility, combines with a reproducibly performing electron column to give you new opportunities for high-resolution 3D characterization, in situ dynamic observation, and other diffraction applications, with a special emphasis on high-contrast imaging and cryo-TEM.

Automation and ease of use

Designed for multi-user and multi-discipline environments, and equipped with a familiar user interface (UI) shared across all Thermo Scientific TEM platforms, the Talos L120C TEM is ideal for novice and expert users alike. All daily TEM tunings have been automated to provide the best and most reproducible setup, easing the learning curve for novice operators, reducing tensions in a multi-user environment, and improving time-to-data for the experienced user. The Talos L120C TEM also offers educational online help embedded within the UI.

Additionally, Thermo Scientific Maps Software enables intuitive image-based navigation over a whole sample along with easy correlation of results across imaging platforms. In order to retrieve large-area imaging at high resolution, Maps Software automatically acquires and stitches images, documenting the entire area of interest with exceptional quality. It supports image import, overlay, and alignment from other microscopes, such as scanning electron or light microscopes. This allows for digital zoom from correlated low-magnification TEM and/or SEM to high-resolution TEM (HRTEM), providing valuable contextual information.

Key Features

Superior images

High-contrast, high-quality TEM and STEM imaging by simultaneous, multiple signal detection with up to four-channel-integration STEM detectors.

Chemical composition data

Flexible energy-dispersive X-ray spectroscopy (EDS) analysis for chemical information.

 

Space for more

Add tomography or in situ sample holders with a large analytical pole piece gap, stage tilt range, and large Z range.

Improved productivity and reproducibility

Ultra-stable column, SmartCam remote operation, and constant power objective lenses for quick mode and high-tension switches. Fast, easy switching for multi-user environments.

 

Auto-alignments

All daily TEM tunings, such as focus, eucentric height, center beam shift, center condenser aperture, and rotation center are automated.

Ceta CMOS Camera

4k × 4K Thermo Scientific Ceta CMOS Camera. Large field-of-view enables live digital zooming with high sensitivity and high speed over the entire high-tension range. 

Compact design

Smaller footprint and dimensions mean this tool can be accommodated into more challenging spaces while reducing infrastructure and support costs.

Cryo-imaging

Retractable cryo-box and low-dose technique enable superior imaging of samples at cryogenic tempartures. Automate single particle analysis imaging with Thermo Scientific EPU Software.


Specifications

TEM line resolution
  • 0.204 nm
TEM point resolution
  • < 0.37 nm
STEM HAADF resolution with LaB6 (nm)
  • ≤ 1.0
EDS side-entry, retractable
  • Must be retracted for cryo work.
Cryo-box side-entry, motorized auto retractable
  • Must be retracted for EDS work
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Applications

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Infectious Disease Research
 

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

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Structural Biology Research
 

Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

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Drug Discovery
 

Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.

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Plant Biology Research
 

Fundamental plant biology research is enabled by cryo electron microscopy, which provides information on proteins (with single particle analysis), to their cellular context (with tomography), all the way up to the overall structure of the plant (large volume analysis).

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Pathology Research
 

Transmission electron microscopy (TEM) is used when the nature of the disease cannot be established via alternative methods. With nano-biological imaging, TEM provides accurate and reliable insight for certain pathologies.

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Quality Control
 

Quality control and assurance are essential in modern industry. We offer a range of EM and spectroscopy tools for multi-scale and multi-modal analysis of defects, allowing you to make reliable and informed decisions for process control and improvement.

 

Fundamental Materials Research_R&amp;D_Thumb_274x180_144DPI

Fundamental Materials Research

Novel materials are investigated at increasingly smaller scales for maximum control of their physical and chemical properties. Electron microscopy provides researchers with key insight into a wide variety of material characteristics at the micro- to nano-scale.

 

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Process Control
 

Modern industry demands high throughput with superior quality, a balance that is maintained through robust process control. SEM and TEM tools with dedicated automation software provide rapid, multi-scale information for process monitoring and improvement.

 

Energy Dispersive Spectroscopy

Energy dispersive spectroscopy (EDS) collects detailed elemental information along with electron microscopy images, providing critical compositional context for EM observations. With EDS, chemical composition can be determined from quick, holistic surface scans down to individual atoms.

Learn more ›

3D EDS Tomography

Modern materials research is increasingly reliant on nanoscale analysis in three dimensions. 3D characterization, including compositional data for full chemical and structural context, is possible with 3D EM and energy dispersive X-ray spectroscopy.

Learn more ›

EDS Elemental Analysis

EDS provides vital compositional information to electron microscope observations. In particular, our unique Super-X and Dual-X Detector Systems add options for enhanced throughput and/or sensitivity, allowing you to optimize data acquisition to meet your research priorities.

Learn more ›

Atomic-Scale Elemental Mapping with EDS

Atomic-resolution EDS provides unparalleled chemical context for materials analysis by differentiating the elemental identity of individual atoms. When combined with high-resolution TEM, it is possible to observe the precise organization of atoms in a sample.

Learn more ›

Electron Energy Loss Spectroscopy

Materials science research benefits from high-resolution EELS for a wide range of analytical applications. This includes high-throughput, high signal-to-noise-ratio elemental mapping, as well as probing of oxidation states and surface phonons.

Learn more ›

In Situ experimentation

Direct, real-time observation of microstructural changes with electron microscopy is necessary to understand the underlying principles of dynamic processes such as recrystallization, grain growth, and phase transformation during heating, cooling, and wetting.

Learn more ›

Particle analysis

Particle analysis plays a vital role in nanomaterials research and quality control. The nanometer-scale resolution and superior imaging of electron microscopy can be combined with specialized software for rapid characterization of powders and particles.

Learn more ›

Multi-scale analysis

Novel materials must be analyzed at ever higher resolution while retaining the larger context of the sample. Multi-scale analysis allows for the correlation of various imaging tools and modalities such as X-ray microCT, DualBeam, Laser PFIB, SEM and TEM.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›

Energy Dispersive Spectroscopy

Energy dispersive spectroscopy (EDS) collects detailed elemental information along with electron microscopy images, providing critical compositional context for EM observations. With EDS, chemical composition can be determined from quick, holistic surface scans down to individual atoms.

Learn more ›

3D EDS Tomography

Modern materials research is increasingly reliant on nanoscale analysis in three dimensions. 3D characterization, including compositional data for full chemical and structural context, is possible with 3D EM and energy dispersive X-ray spectroscopy.

Learn more ›

EDS Elemental Analysis

EDS provides vital compositional information to electron microscope observations. In particular, our unique Super-X and Dual-X Detector Systems add options for enhanced throughput and/or sensitivity, allowing you to optimize data acquisition to meet your research priorities.

Learn more ›

Atomic-Scale Elemental Mapping with EDS

Atomic-resolution EDS provides unparalleled chemical context for materials analysis by differentiating the elemental identity of individual atoms. When combined with high-resolution TEM, it is possible to observe the precise organization of atoms in a sample.

Learn more ›

Electron Energy Loss Spectroscopy

Materials science research benefits from high-resolution EELS for a wide range of analytical applications. This includes high-throughput, high signal-to-noise-ratio elemental mapping, as well as probing of oxidation states and surface phonons.

Learn more ›

In Situ experimentation

Direct, real-time observation of microstructural changes with electron microscopy is necessary to understand the underlying principles of dynamic processes such as recrystallization, grain growth, and phase transformation during heating, cooling, and wetting.

Learn more ›

Particle analysis

Particle analysis plays a vital role in nanomaterials research and quality control. The nanometer-scale resolution and superior imaging of electron microscopy can be combined with specialized software for rapid characterization of powders and particles.

Learn more ›

Multi-scale analysis

Novel materials must be analyzed at ever higher resolution while retaining the larger context of the sample. Multi-scale analysis allows for the correlation of various imaging tools and modalities such as X-ray microCT, DualBeam, Laser PFIB, SEM and TEM.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›


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Electron microscopy services

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.

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