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Bringing cryo-electron microscopy to you

Whether you’re an experienced microscopist, or just starting out, the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM) is a dedicated structural-analysis solution designed to bring cryo-electron microscopy (cryo-EM) to your laboratory at an affordable price point. Simplified data collection and rapid sample loading/unloading make the Tundra Cryo-TEM a powerful tool for answering your most challenging research questions. With the Tundra Cryo-TEM, you can obtain structures at biologically relevant resolutions in-house or reliably prepare high-quality samples for further analysis on Thermo Scientific Krios or Glacios Cryo-TEMs.
 

Molecular structures determined using the Tundra Cryo-TEM

 

 

Tundra Cryo-TEM key benefits

Cryo-TEM sample preparation and optimization

The Tundra Cryo-TEM can visualize the impact of biochemical adjustments to samples faster than other technologies. Exchange samples in and out of the microscope in minutes, with nearly instantaneous feedback, allowing you to optimize your sample conditions quickly without extensive training.

Cryo-EM structures at biologically relevant resolution

The optics of the Tundra Cryo-TEM are specifically designed so that you can answer fundamental questions on biology and human disease with data at biologically relevant resolutions. Operating at 100 kV, the Tundra Cryo-TEM can generate high-contrast biological images down to 3.5 Å at medium throughput with its high-performance, fraction-enabled Thermo Scientific Ceta Camera.

Meet your budget

Meet your budget

A wide range of funding proposals and grants were considered when designing the Tundra Cryo-TEM to keep its price within the reach of most instrumentation grants. Our Electron Microscopy Funding Support Center has additional information about our financial services as well as grant-writing guidance so you can get the tools you need, when you need them.

Artificial intelligence takes the guesswork out of cryo-TEM

Artificial intelligence takes the guesswork out of cryo-TEM

The Tundra Cryo-TEM comes with a complete suite of automation software for efficient optimization of your sample’s biochemistry as well as data collection for structural determination. This includes a user-friendly AI-enabled software solution capable of analyzing intermediate results, providing instant feedback, and steering data collection on the fly. Our AI algorithms are based on years of cryo-EM knowledge, providing expert decisions upfront to ensure that your instrument is working at optimal conditions. Focus on the science rather than on fine-tuning the microscope.

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Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

 

 

How can the Tundra Cryo-TEM help you?

If you...

The ease-of-use features and guided automation of the Tundra Cryo-TEM makes it easy to get started in cryo-EM and offers a price point within the reach of many grants and funding sources.

The Tundra Cryo-TEM offers efficient sample iteration and optimization. Train new team members on cryo-EM without losing valuable time on your Glacios or Krios Cryo-TEM.

The Tundra Cryo-TEM allows you to bring cryo-EM on-site; projects that don’t require highest resolution analysis aren’t stuck waiting on instruments with high demand. You can also produce the best possible samples when off-site analysis is needed, since the Tundra Cryo-TEM allows you to quickly assess grid quality.

You can train new team members on cryo-EM without losing valuable time on your Glacios or Krios Cryo-TEMs. The Tundra Cryo-TEM also acts as a dedicated microscope for quick sample quality assessment.

The ease-of-use features and guided automation of the Tundra Cryo-TEM makes it easy to get started in cryo-EM and offers a price point within the reach of many grants and funding sources.

The Tundra Cryo-TEM offers efficient sample iteration and optimization. Train new team members on cryo-EM without losing valuable time on your Glacios or Krios Cryo-TEM.

The Tundra Cryo-TEM allows you to bring cryo-EM on-site; projects that don’t require highest resolution analysis aren’t stuck waiting on instruments with high demand. You can also produce the best possible samples when off-site analysis is needed, since the Tundra Cryo-TEM allows you to quickly assess grid quality.

You can train new team members on cryo-EM without losing valuable time on your Glacios or Krios Cryo-TEMs. The Tundra Cryo-TEM also acts as a dedicated microscope for quick sample quality assessment.

 

 

Tundra Cryo-TEM support

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Cryo-EM Funding Center

Cryo-EM Funding Center

Securing funding can be demanding, time-consuming, and stressful. Our Cryo-EM Funding Center offers proposal writing tools as well as access to technical experts who can guide you through the process.

View support center

Tundra Cryo-EM service and support

Tundra Cryo-EM service and support

Our service and support options ensure that you maximize your instrument uptime and data quality.
 

 Download brochure

Cryo-EM Ask the Experts Series

Cryo-EM Ask the Experts Series

Watch and engage with cryo-electron microscopy researchers while they discuss the practical and theoretical aspects of their work.

Register now

 

 

Tundra Cryo-TEM specifications

Technical highlights of the Tundra Cryo-TEM

  • 3.5 Å apoferritin structure determination in 24-72 hours
  • High-brightness X-FEG (extreme field emission gun)
  • Fixed accelerating voltage of 100 kV
  • Semi-automated sample loading
  • Cryo-preparation station allowing contamination-free sample exchange
  • Sample transfer device for transferring single AutoGrids to the microscope
    • Fixed cryo-box that keeps samples contamination free for up to 72 hours
  • Computerized specimen cryo-stage
  • High-performance Thermo Scientific Ceta Camera with dose fractionation, optimized for low-dose imaging
  • Smart EPU Software for automated single particle analysis screening and data acquisition. Includes an open application programming interface

 

 

Tundra Cryo-TEM resources 

The Tundra Cryo-TEM is a dedicated structure-determination solution designed to bring single particle analysis to every biochemistry laboratory.

Dr. Jiri Novacek from CEITEC, Masaryk University, discusses how cryo-EM is accelerating his plant research, by understanding the structure and function of plum pox virus.

Dr. Jared Auclair, Director of Biopharmaceutical Analysis Laboratory, Northwestern University, talks about using the Tundra Cryo-TEM to gather data on molecules including batch-to-batch consistency. The automation, flexibility, and integration of cryo-EM is critical in biopharmaceutical laboratories.

Dr. James Whisstock, professor from Monash University, discusses how the Tundra Cryo-TEM can collect complete data sets at near atomic resolution in less than a few days for structural drug discovery.

tundra-relaunch-webinar-460x270

Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

The Tundra Cryo-TEM is a dedicated structure-determination solution designed to bring single particle analysis to every biochemistry laboratory.

Dr. Jiri Novacek from CEITEC, Masaryk University, discusses how cryo-EM is accelerating his plant research, by understanding the structure and function of plum pox virus.

Dr. Jared Auclair, Director of Biopharmaceutical Analysis Laboratory, Northwestern University, talks about using the Tundra Cryo-TEM to gather data on molecules including batch-to-batch consistency. The automation, flexibility, and integration of cryo-EM is critical in biopharmaceutical laboratories.

Dr. James Whisstock, professor from Monash University, discusses how the Tundra Cryo-TEM can collect complete data sets at near atomic resolution in less than a few days for structural drug discovery.

tundra-relaunch-webinar-460x270

Cryo-TEM webinar

Learn more about the Tundra Cryo-TEM in this 30 minute on-demand webinar, including:

  • How to make impactful structural biology discoveries with the Tundra Cryo-TEM.
  • Easier sample loading and retrieval with our novel, semi-automated loading system.
  • And more ...

Register to watch

 

 

Smart EPU software for Cryo-TEM

User-friendly software for day-to-day operation

  • Microscope-embedded solution for single particle analysis and data acquisition
  • Reduced need for prior expertise: software assists with experimental set-up, providing real-time feedback
  • Optimized for high-throughput particle collection

The open API of Smart EPU Software allows you to develop your own functions for the Tundra Cryo-TEM.

 

 

Tundra Cryo-TEM applications

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Infectious disease research

Infectious Disease Research

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

Structural biology research

Structural Biology Research

Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

Neurodegeneration Research

Neurodegenerative Disease Research

Cryo-EM can determine the structural features of protein aggregates implicated in neurodegenerative diseases, allowing scientists to address how they form, interact with the cellular environment, and alter brain function.

 

 

Tundra Cryo-TEM techniques

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›


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Electron microscopy services

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.

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