Techniques used to separate anchorage-dependent mammalian cells from microcarrier beads include: sedimentation using conical or incline settlers, centrifugation, acoustic resonance, spin filtration and microfiltration. These techniques often use sophisticated equipment that require a significant capital expenditure as well as routine maintenance and between-use cleaning and sterilization. The 200 L Thermo Scientific™ Harvestainer™ BioProcess Container offers a robust and economical alternative to other systems.