Predicting the crystalline nature of APIs with a novel in-line X-ray technique: InsituX

mRNA vaccines are a new type of vaccine against infectious diseases. Traditionally, vaccines use a weakened or inactivated form of a pathogen to trigger an immune response. mRNA vaccines, however, enable cells to synthesize a protein that triggers a potent immune response against infectious disease. Manufacturing mRNA vaccines is a complex process that requires highly purified ingredients to ensure the desired result is achieved.

Bacterial growth rate and nucleotides are the main components that impact the manufacture mRNA vaccines for COVID-19 prevention. In this webinar, Naimish Sardesai of Thermo Fisher Scientific explains how bacterial growth rate influences gene expression by acting on both sides of the mRNA equilibrium: synthesis and degradation. Sardesai will also discuss how Thermo Fisher Scientific’s GENESYS and Evolution series UV/Vis spectrophotometers can be used to evaluate and achieve optimum bacterial culture growth rate, and measure oligonucleotide quality to ensure vaccines produced are not contaminated.

Key learning objectives

·         How to determine the time needed for optimal bacterial growth in mRNA vaccine production
·         How to evaluate the quality of oligonucleotides used for mRNA vaccine production
·         How to use UV/Vis spectroscopy as a quality assurance tool in vaccine research and process control

Who should attend?
·         Vaccine researchers
·         Pharmaceutical quality assurance lab managers
·         Protein and cell biologists

Naimish Sardesai
Speaker:  Naimish Sardesai, Product Manager, UV/Vis Spectroscopy, Thermo Fisher Scientific
Naimish Sardesai has a Bachelors in Pharmaceutical Sciences and a PhD in Analytical Chemistry. He has more than 10 years of experience in the field of spectroscopy and joined Thermo Fisher in 2020 as a product manager for UV/Vis and NMR Spectroscopy.

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