Thermo Fisher Scientific
Despite advances in analytical chemistry, it is becoming increasingly challenging to control prohibited substance abuse in equine athletes. A problem is the ever-increasing number of prohibited substances, resulting in the need for large custom-made compound databases and mass spectral libraries.
In this webinar, we discuss the development of a >440 compound screen, with a custom-built mass spectral library and compound database along with the transfer of this method from a Thermo Scientific Orbitrap Exploris 480 MS to a Thermo Scientific TSQ Altis mass spectrometer for confirmation. We demonstrate the integration of multiple software tools including mzCloud, mzVault and Thermo Scientific TraceFinder SW for a holistic view of method development beyond analytical capabilities.
Researchers and leaders in Academia, bio/pharma, clinical, forensic toxicology, and protein research; any laboratories who are focused on both small molecule and protein identification and quantitation workflows, where there is the need to transfer knowledge from research through to routine.
Scott Stanley, Ph.D., Professor in Equine Toxicology and Pharmacology, Department of Veterinary Science and Director of the Equine Analytical Chemistry Laboratory, University of Kentucky
Dr. Stanley received his doctoral degree in Toxicology in 1992, and his bachelor’s degree in Animal Science in 1988 from the University of Kentucky. He was a faculty member at University of California-Davis since 1997 through 2018. At UC-Davis, Dr. Stanley was the chief chemist of the Kenneth L. Maddy Equine Analytical Chemistry Laboratory. He modernized drug testing in California horse racing by introducing new, state-of-the-art instrumental drug testing equipment and procedures. He has also worked closely with manufactures in adapting newer technologies to equine drug testing. Dr. Stanley moved to the University of Kentucky in early 2019, his current research interests are related to drug testing methods for the detection of biopharmaceuticals, natural products and designer drugs, and the establishment of the Equine Biological Passport project.
Sophie Bromilow, Ph.D., Scientist III at Equine Analytical Research Laboratory, University of Kentucky
Dr. Bromilow received her doctoral degree in Biology, Medicine and Health focused on Proteomics in 2018 from the University of Manchester, and her bachelor’s degree in Chemistry 2013 from the University of Liverpool. Following the completion of her Ph.D Dr. Bromilow joined UC Davis under Dr. Stanley’s supervision to undertake Post-Doctoral Research. During this time, Dr. Bromilow applied her proteomics expertise to Equine Anti-Doping Strategies and began to establish the Equine Biological Passport, showing the first proof of concept for the use of biomarkers as indicators of prohibited substance abuse. Dr. Bromilow has since continued her research under Dr. Stanley’s supervision at the University of Kentucky.
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