Back to Basics - Characterization of Biopharmaceutical Proteins

In today's rapidly evolving biopharmaceutical landscape, precise characterization is paramount to ensure product quality, safety, and efficacy. Join us for an in-depth exploration of liquid chromatography-mass spectrometry (LC-MS) as a powerful tool for the comprehensive characterization of biopharmaceutical proteins.

Led by Dr. Jonathan Bones, this webinar will delve into the advanced applications of LC-MS in biopharmaceutical analysis. Attendees will gain a deep understanding of how LC-MS techniques can be leveraged to elucidate the structural attributes, post-translational modifications, and oxidation profiles of therapeutic proteins. Application results for intact mass analysis, sub-unit analysis, peptide mapping, native MS and multi-attribute monitoring (MAM) will be described.

Key learning objective:

Comprehensive understanding of LC-MS methodologies for protein characterization
Learn how to interpret and utilize LC-MS data to understand structural attributes of biopharmaceutical proteins

Who should attend:

Professionals working in biopharmaceutical companies, focusing on research and development, analytical development, and quality control
Researchers in biopharmaceutical research and development

Speaker:

Jonathan Bones, PhD

Principal Investigator
The National Institute for Bioprocessing Research and Training (NIBRT)

Biography

Dr Jonathan Bones received his PhD in Analytical Chemistry from Dublin City University in 2007. He then transitioned to NIBRT, to Professor Pauline M. Rudd’s lab. In 2010, Dr Bones moved to the Barnett Institute of Chemical and Biological Analysis at Northeastern University, Boston, to work with Professor Barry L. Karger. In 2012, he returned to NIBRT, where he currently services as a principal investigator of the NIBRT Characterization and Comparability Laboratory. Dr Bones is also an associate professor for the School of Chemical and Bioprocess Engineering at University College Dublin.