Workflows for the analysis oligonucleotides by high resolution LCMS to support therapeutic drug development can often cover a wide range of modalities, ranging from heavily modified sequences to very large chains that exceed more than 50 nucleotide bases. The analytical need to support such complex and varied oligonucleotide sequences requires both high quality LCMS data as well as comprehensive and easy to use data processing tools.

In this webinar, we will explore the data quality produced by the high-resolution LCMS analysis of a range of oligonucleotides sequences as well as the setup and processing of the subsequent results. Tools and workflows designed to automatically identify and confirm both full length product as well as product impurities will be discussed including data processing and visual display capabilities intended to simplify sample analysis and streamline data review.


  • Discover new end-to-end- LC-MS workflows for oligonucleotide analysis
  • How to identify and confirm full length oligonucleotides and product impurities
  • How easy to use software tools allow comprehensive analysis of a range of oligonucleotides

About the presenter

Keeley Murphy, Software Product Manager, Thermo Fisher Scientific

Keeley Murphy
Software Product Manager
Thermo Fisher Scientific

Keeley Murphy is a Software Product Manager with over 20 years experience working in the fields of pharmaceutical and analytical science. Over the last 10 years, Keeley has worked within the BioPharma Marketing group at Thermo Fisher Scientific (MA, USA), providing global support for key customer collaborations and promoting the use of high-resolution mass spectrometry for quantitative bioanalysis. Recently transitioning to the role of Software Product Manager, he is currently responsible for the development of software solutions to support LC–MS quantitation and screening workflows.

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