Find structure and function with cryo-tomography
The interior of cells can be mysterious. Access the inner-workings of cells in 3D and at unprecedented nanoscale resolution using cryo-electron tomography. Cryo-electron tomography avoids the alterations caused by conventional chemical fixation and dehydration resulting in the imaging of cellular morphology and proteins under fully hydrated, near-native conditions. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity.
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Explore a curated collection of scientific publications highlighting the use of cryo-electron tomography including:
- Endoplasmic reticulum-associated degradation machinery at distinct microsites near the ER
- Discovery of ER sub-compartments known as ribosome-associated vesicles
- Lewy bodies and neurites stuffed full of membranes, not protein filaments
- In situ structure of Parkinson's disease-linked LRRK2
- More reviews of articles from cell biology, neuroscience, microbiology, and virology
Prof. Ariane Briegel from Leiden University was plenary speaker at ASM Microbe 2019. She discusses how cryo-electron tomography is overcoming research barriers faced in microbiology and gives her top tips for working with the technology.
We’ve created this learning center to connect scientists around the world to the latest information on electron microscopy technology and to guide you to the best solution that will accelerate your next discovery or breakthrough.