Connect structure with function with cryo-tomography
Cryo-Electron Tomography eBook

The interior of cells can be mysterious. Access the inner-workings of cells in 3D and at unprecedented nanoscale resolution using cryo-electron tomography (cryo-ET). Cryo-ET avoids the alterations caused by conventional chemical fixation and dehydration resulting in the imaging of cellular morphology and proteins under fully hydrated, near-native conditions. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity. 

Explore how cryo-ET is bridging the gap between light microscopy and atomic-resolution techniques like single particle cryo-electron microscopy in: 

  • Cell biology
  • Neuroscience
  • Microbiology
  • Virology

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