Search Thermo Fisher Scientific
Ion Chromatography Applications for Pharmaceutical Analysis
Click below to download our pharmaceutical analysis applications
Thermo Scientific Dionex Ion Chromatography (IC) instruments are used for many pharmaceutical applications as prescribed in the US/European/China pharmacopeia for a range of molecules which are present as counter ions, impurities, degradants and related substances and diastereomers. We've consolidated the application notes you need on a range of topics, including the new USP monographs that recommend our instrument and column chemistry in place of titration methods.
Fill out the form to access a selection of our most popular and latest ion chromatography methods
Implementation of Walk-Up High-Pressure Capillary Ion Chromatograph
Learn the advantages of high pressure capillary IC for fast separations of pharmaceutical relevant anions and cations.
Assay for Citrate and Phosphate in Pharmaceutical Formulations
This work is an update to Application Note 164 (featured in the United States Pharmacopeia (USP)) using fast separations and an HPIC system to reduce run times by 50%-- from 10 minutes to 5 minutes.
Quantification of Carbohydrate and Glycols in Pharmaceuticals
Understand the use of three different anion-exchange columns with amperometric detection to analyze common simple sugars, sugar alcohols, and glycols in pharmaceutical formulations.
Determination of Ammonia in Sodium Bicarbonate
Read about an IC-based method for the determination of ammonia (as ammonium) in sodium bicarbonate. The method performance characteristics were measured according to the requirements described in the USP General Chapter <1225> guidelines.
Assay of potassium bitartrate using ion chromatography
See how an IC method is developed to replace the titrimetric assay for potassium bitartrate in the United States Pharmacopeia (USP) Potassium Bitartrate monograph.
Ion chromatography assay for lithium in lithium citrate
Study this alternative method for lithium citrate analysis that is automated, fast, and uses an aqueous mobile phase (eluent). IC offers a significant improvement to the existing assays because it can simultaneously determine lithium, sodium, calcium, and other common cations in a single injection.
Determination of zinc oxide in sunscreen using ion chromatography with visible absorbance detection
See how this IC method developed for the assay of zinc oxide in sunscreen based on the method in the proposed zinc oxide monograph is demonstrated.
Determination of fluoride in tooth gel containing sodium fluoride
Get an understanding of the efficacy of the Thermo Scientific Dionex IonPac AS15-5µm column for the determination of fluoride in sodium fluoride tooth gel.
Determination of oxalate in cromolyn sodium
Learn an automated and fast alternative method for oxalate determination using IC, a significant improvement to the existing assay described by the USP.
HPAE-PAD determination of cyclodextrins
Evaluate how the Thermo Scientific™ Dionex™ CarboPac™ PA200 column for the separation of α, β, and γ-cyclodextrins and for the determination of β-CD according to the USP Betadex Sulfobutyl Ether Sodium monograph.
IC-MS for the determination of organic acids in pharmaceutical solutions
The goal of this work is to develop a simplified IC application in conjunction with mass-selective detection to facilitate the identification and quantification of highly polar aliphatic and unsaturated organic acids in pharmaceutical solutions.
Style Sheet for Global Design System