On-demand webinar library
Integrative structural biology combines structural and functional information from various techniques, including cryo-electron microscopy (cryo-EM) and mass spectrometry (MS), to arrive faster at a more complete picture of a protein and its function.
Register now to access our growing library of integrative structural biology webinars and find out how this approach can help you answer your most challenging biological questions. In these webinars, you can:
- See a cryo-EM structure of the ~80 kDa heavily glycosylated human coronavirus HKU1 hemagglutinin esterase at a global resolution of 3.4 Å
- Discover architectural changes arising from prolonged adaptation of HKU1 to humans
- Gain new insight into the evolution and host adaptation of human embecoviruses
- Hear about how single-particle cryo-EM enables the structural determination of numerous flexible and conformationally heterogeneous protein assemblies at high resolution
- Learn about time-saving native MS that provides rapid and reliable feedback on sample quality prior to cryo-EM analysis
- Hear about cryo-EM and the development of vaccine development
- Learn how combining structures from cryo-EM with glycan characterization can improve our understanding of SARS-COV-2 immune response
Meet the speakers:
Dr. Joost Snijder, Assistant Professor, Utrecht University
Dr. Snijder received his doctorate degree cum laude as part of the Biomolecular Mass Spectrometry and Proteomics Group of Albert Heck. In 2019, with the support of the NWO Gravitation program Institute for Chemical Immunology, he started his own research group at Utrecht University that explores integrative structural biology, combining mass spectrometry and cryo-EM to characterize viral glycoproteins and antiviral antibodies.
Dr. Ieva Drulyte, Cryo-EM Application Specialist, Thermo Fisher Scientific
Dr. Drulyte obtained her doctorate from the School of Molecular and Cellular Biology at the University of Leeds, where she used X-ray crystallography, cryo-EM, and nuclear magnetic resonance spectroscopy to characterize the structure and dynamics of enzyme complexes involved in polyketide natural product biosynthesis. In 2018, she joined Thermo Fisher Scientific, where she provides application support and workflow demonstrations to customers, performs system acceptance tests, and contributes to new software and hardware developments in R&D.
Dr. Paul Dominic B. Olinares, Associate Researcher, Rockefeller University, NY
Dr. Paul Dominic B. Olinares received his doctorate degree from Cornell University in 2011, after which he joined the laboratory of Brian Chait at Rockefeller University as a research associate. Here, he is currently developing native MS-based methods for integrative structural biology characterization of protein complexes, particularly concerned with integrating native MS in sample preparation workflows prior to cryo-EM analysis.
Dr. Albert Konijnenberg, Product Manager, cryoEM Sample Preparation and Integrative Structural Biology, Thermo Fisher Scientific
Albert Konijnenberg obtained his PhD from the University of Antwerp in Belgium in 2016. His thesis research focused on method development to apply native mass spectrometry techniques for studying protein structure in the gas phase, with a strong focus on intrinsically disordered and integral membrane proteins. After postdocs at the Flemish Institute for Biotechnology and the University of Antwerp, he joined Thermo Fisher Scientific in 2017, where he champions initiatives supporting cryoEM sample preparation and integrative structural biology techniques.