Microcrystal Electron Diffraction (MicroED) is becoming a critical new tool for structural analysis of organic molecules, enabling the study of three-dimensional crystals one billion times smaller than volumes used for X-ray crystallography. Since its 2013 demonstration, led by Tamir Gonen, the MicroED method to determine high-resolution protein structures in a cryo-electron microscope is helping researchers to understand major brain diseases like Parkinson’s disease, as well as to discover and design new drugs, shed new light on chemical synthesis and small molecule chemistry, and reveal unprecedented levels of detail in subatomic resolutions.
In a recent webinar, Dr. Tamir Gonen from UCLA and Dr. Christopher Arthur from Genentech discussed how MicroED could be used for small molecule and protein structure determination in new drug design and discovery. After the webinar, Dr. Gonen and Dr. Arthur gave us the answers to some of the top questions when it comes to working with small molecules and protein samples for Microcrystal Electron Diffraction.
Top MicroED questions answered
If you missed the webinar, register to watch it on-demand.