Multi-class Veterinary Drug Quantitation with a Comprehensive Workflow

The screening and routine quantitation of veterinary drugs in food products is one of the most important and demanding applications in food safety. Despite the recent technological advancements in LC-MS, it is still challenging to obtain excellent chromatographic peak shapes, adequate sensitivity, and accurate quantitation of more than 170 veterinary drugs from different chemical classes within a single, multi-class method.

This presentation describes the development and implementation of a comprehensive multi-class veterinary drug method based on LC-MS/MS using a generic QuEChERS sample preparation. The method was validated in bovine muscle, salmon fillet, and milk to demonstrate applicability to a wide range of matrices. The method detection limits obtained were compliant with the lowest global MRLs for each analyte/matrix combination.

Key Learning Objectives:

Address critical challenges in quantitation of veterinary drugs in food laboratories using triple quadrupole MS instrumentation
Learn about new column technology for the separation of veterinary drugs
Learn about a robust, routine workflow that can increase laboratory and organizational productivity

About the presenter

Ed George, Senior Applications Scientist, Environmental and Food Safety, Thermo Fisher Scientific

Ed George has a BS in Chemistry from the University of Notre Dame with a concentration in Environmental Science. He worked for 15 years in the commercial environmental laboratory industry, responsible for developing novel sample preparation and analysis methods for a range of contaminants in water and solid waste by GC-MS/MS and LC-MS/MS. He participated in several collaborative method development projects with the US EPA. From 2005–2009, he worked for Varian, Inc. as an Application Lab Manager. Ed joined Bruker Daltonics in January 2010 as an applications chemist and later became Product Manager for the Scion single quadrupole instrument. Ed joined Thermo Fisher Scientific in 2014 where he’s worked in the Environmental and Food Safety Vertical marketing team developing applications and solutions for triple quadrupole as well as High Resolution Mass Spectrometers.