The screening and routine quantitation of veterinary drugs in food products is one of the most important and demanding applications in food safety. Despite the recent technological advancements in LC-MS, it is still challenging to obtain excellent chromatographic peak shapes, adequate sensitivity, and accurate quantitation of more than 170 veterinary drugs from different chemical classes within a single, multi-class method.
This presentation describes the development and implementation of a comprehensive multi-class veterinary drug method based on LC-MS/MS using a generic QuEChERS sample preparation. The method was validated in bovine muscle, salmon fillet, and milk to demonstrate applicability to a wide range of matrices. The method detection limits obtained were compliant with the lowest global MRLs for each analyte/matrix combination.
Key Learning Objectives:
- Address critical challenges in quantitation of veterinary drugs in food laboratories using triple quadrupole MS instrumentation
- Learn about new column technology for the separation of veterinary drugs
- Learn about a robust, routine workflow that can increase laboratory and organizational productivity
