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The NanoDrop 2000/2000c Spectrophotometer is stepping down
Thermo Fisher Scientific will discontinue sales of the Thermo Scientific NanoDrop 2000/2000c Microvolume UV-Vis Spectrophotometers on September 24, 2021.
We are committed to servicing NanoDrop 2000/2000c instruments globally through September 23, 2028. For any questions regarding service, please contact nanodrop@thermofisher.com or your local NanoDrop instruments distributor.
The Thermo Scientific NanoDrop One/OneC Microvolume UV-Vis Spectrophotometer can take over the quantification and assessment of DNA, RNA, proteins and more in your lab. It offers some amazing new quantification and compliance capabilities.
| NanoDrop 2000/2000c Spectrophotometer | NanoDrop One/OneC Spectrophotometer | |
|---|---|---|
| Wavelength Range | 190 - 840 nm | 190 - 850 nm |
| Dynamic range (pedestal measurements) | 2.0 - 15,000 ng/µL for dsDNA | 2.0 - 27,500 ng/µL for dsDNA |
| Nucleic acid applications including oligos and microarrays | ✓ | ✓ |
| Direct protein assessment including A280, A205, proteins and labels | ✓ | ✓ |
| Protein colorimetric assays | ✓ | ✓ |
| Custom methods, OD600, kinetics | ✓ | ✓ |
| Identifies and corrects for sample contaminants | ✓ | |
| Stand-alone touch screen interface | ✓ | |
| PC software with 21 CFR Part 11 compliant software option | ✓ |
The NanoDrop One Spectrophotometer – standalone instrument
- High-definition touchscreen
- Glove compatible operation
- Screen tilts up and down
- Screen slides left and right
- Small footprint
The NanoDrop One Spectrophotometer – optional PC control software
- Easily connect to a PC with internet cable
- Save data directly to the PC
Optional Security Suite software for 21 CFR Part 11 compliance
- Manage networked instruments simultaneously
- Manage user accounts and passwords via Windows™
NanoDrop One UV-Vis Spectrophotometers allow labs to distinguish DNA from RNA, helping to ensure sample purity for the success of downstream analyses.
How it works
The Thermo Scientific Acclaro Technology software that operates the NanoDrop One instrument employs chemometric algorithms to process sample spectra and differentiate dsDNA absorbance from RNA absorbance.
When the software identifies a contaminant, it notifies users with a yellow triangle next to the sample 
. Selecting the yellow icon displays the original sample, the contaminant, and the corrected analyte spectra. A table reports the corrected concentration, so users know what contaminant is present and whether to use the sample in downstream experiments. Users can proceed with confidence in the rest of their analysis.
Application Note: Detection of RNA contamination in Mammalian DNA preparations
This video walks through a workflow of measuring nucleic acid samples, then identifying and correcting DNA/RNA contamination with NanoDrop One UV-Vis Spectrophotometers.
Optional Security Suite software enables regulated labs to use the proven NanoDrop One UV-Vis Spectrophotometers to quantify biological molecules.
The software offers a compliance package to help meet requirements for electronic records in Title 21 CFR Part 11 regulation from the US Food and Drug Administration. Here are a few highlights:
Authorization and system access. Click to enlarge
Electronic records and signatures. Click to enlarge
Audit trails. Click to enlarge
You can also discuss a new NanoDrop spectrophotometer directly with your local distributor, or request a free trial.