Phenylephrine HCl is a nasal decongestant that provides relief from discomfort caused by colds, allergies, and hay fever. Robust, reproducible, sensitive, and affordable quantitation workflows for phenylephrine HCl are extremely important for determining the dosage amount, concentration in samples, quantifying it as a drug of abuse if consumed, and ensuring purity. In addition, developing robust and accurate quantitation assays for quantifying phenylephrine HCl in water is critical for quality control (QC) and quality assurance (QA) processes.
This application note describes an easy-to-use and easy-to-implement quality control workflow for the analysis and quantitation of phenylephrine hydrochloride for QA/QC using Vanquish Flex UHPLC system and the Thermo Scientific™ TSQ Fortis™ Triple Quadrupole Mass Spectrometer.
