DNA methylation is a fundamental biochemical process that occurs in every tissue and organ system in the body. The study of this process helps researchers identify potential biomarkers and understand how the function of the genetic sequence is implemented and regulated. DNA Methylation is widely studied for its association with cancer, autoimmune disorders and other complex diseases such as Alzheimer’s disease.
Next-generation sequencing (NGS) enables high-throughput sequencing, mapping, and counting of short DNA reads (tags). In combination with traditional methylation profiling strategies (bisulfite conversion, digestion with methylation-sensitive restriction enzymes, and antibodyor 5-methylcytosine binding protein–based purification), NGS can be used for comprehensive, genome-wide mapping of methylation sites.
High accuracy, easy to use and short time-to-answer with low DNA input
With Ion Torrent focused next-generation sequencing (NGS) technology, you get the speed, scalability and precision you need so that you can spend more time finding answers and less time looking for them. Further your epigenetics research with our comprehensive NGS solution, which enables a complete, targeted 3-day* workflow for quantitative methylation analysis across multiple loci when combined with the bisulfite conversion method.