Real-time PCR is used for sensitive, specific detection and quantification of nucleic acid targets. Whether you are focused on infectious disease research, pharmaceutical analysis, or food pathogen detection, we have applications, assay design algorithms, optimized master mixes, intuitive
Generate high-quality data with our proven workflow. Sanger sequencing is the gold-standard technology to study diseases with clearly defined phenotypes. Sequence 1-96 samples at a time without barcoding and confirm next-generation sequencing (NGS) variants with up to 99.99% accuracy.
Go beyond sequencing. While DNA sequencing by capillary electrophoresis is used to determine the specific base sequence of a particular fragment or gene segment, fragment analysis can provide sizing, relative quantitation, and genotyping information for fluorescently labeled DNA fragments produced by PCR using primers designed for a specific DNA target.
This application note covers strategies for designing fragment analysis-based target multiplexing solutions. It explains how fragment analysis by capillary electrophoresis can provide a sensitive method for detecting pathogens, and includes a simple method for detecting SARS-CoV-2 viral sequences.
This white paper explores why genome editing efficiency is important, covers various genetic analysis methods (each with particular strengths) that can be used to evaluate genome editing efficiency, and describes Thermo Fisher's complete workflow solutions for genome editing experiments.
Liquid biopsy is an emerging area of clinical research, particularly in the context of cancer. As a minimally invasive complementary or alternative approach to tissue biopsies, liquid biopsies are less risky, painful, and costly, and are increasingly being used to analyze biomarkers in liquid samples, such as blood.
To meet the need for more comprehensive coverage of respiratory pathogens, we introduce a panel-based molecular solution that detects a wide range of respiratory viruses, bacteria, and fungi in a single assay.
The field of cytogenetics is important for scientific research and medical diagnoses, and it can help us understand reproductive health, cancer, and other diseases. To date, technological advances have helped detect gene alterations, SNPs, numerical chromosome alterations, and more.
This white paper describes the development and use of chromosomal microarrays for analyzing chromosomal anomalies. It also covers the benefits of using chromosomal microarrays over traditional G-band karyotyping and includes case studies of instances where chromosomal microarrays detected anomalies that were missed by G-banding.
From evidence to answers. We offer simple, complete, end-to-end workflows for forensic DNA analysis to help resolve difficult cases and provide investigative leads in a forensically responsible and relevant manner.
Around the world, forensic DNA labs are being asked to do more with less. Applied Biosystems GlobalFiler, GlobalFiler IQC, and GlobalFiler Express PCR amplification kits combine reduced amplification time with exceptional discrimination power, enabling forensic researchers to maximize information recovery, even with the most challenging casework sample types.
With the translation of predictive genomics from research to the clinic, health systems are moving from a model of sick care to preventive care. It’s a new paradigm in which disease causation is clarified and the right intervention is identified for every individual.
The translation of biomarkers from discovery to routine clinical applications is vital to the future of precision medicine. Yet, applying these discoveries and associating population-specific variants to individual traits, diseases, and potential downstream treatment options remains one of the most challenging barriers to personalized genomics.
In the past, custom genotyping arrays were expensive, required large sample commitments, and took a lot of time to design and deliver.Applied Biosystems™ Axiom™ myDesign™ Custom Genotyping Arrays overcome these challenges by offering a fast, cost-effective way to modify an existing array or create an entirely new design for as few as 480 samples.